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Influenza is an independent risk factor in the development of invasive pulmonary aspergillosis, according to a study published in The Lancet Respiratory Medicine. Influenza also increases the rate of mortality in individuals with invasive pulmonary aspergillosis.
This retrospective, multicenter cohort study included 432 patients admitted to the intensive care unit with influenza, as well as 315 controls with community-acquired pneumonia. Of the influenza group, 19% (n=83) were diagnosed with invasive pulmonary aspergillosis within a median of 3 days post-admission. Similar incidences were seen for both influenza A and B. The rate of invasive pulmonary aspergillosis was 32% in those with influenza who were also immunocompromised (38 of 117). However, patients with influenza who were not immunocompromised (45 of 315) had a lower incidence of invasive pulmonary aspergillosis (14%). The control group experienced a 5% (n=16) incidence of invasive pulmonary aspergillosis.
This retrospective, multicenter cohort study included 432 patients admitted to the intensive care unit with influenza, as well as 315 controls with community-acquired pneumonia. Of the influenza group, 19% (n=83) were diagnosed with invasive pulmonary aspergillosis within a median of 3 days post-admission. Similar incidences were seen for both influenza A and B. The rate of invasive pulmonary aspergillosis was 32% in those with influenza who were also immunocompromised (38 of 117). However, patients with influenza who were not immunocompromised (45 of 315) had a lower incidence of invasive pulmonary aspergillosis (14%). The control group experienced a 5% (n=16) incidence of invasive pulmonary aspergillosis.
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