some snippets from flu-papers found while googling

[gsgs]

http://www.citeulike.org/user/zwang/article/3934872

Interferon treatment initiated one day prior to challenge significantly reduced or
prevented infection of guinea pigs

Priming with Cold-Adapted Influenza A Does Not Prevent Infection but Elicits Long-Lived Protection
against Supralethal Challenge with Heterosubtypic Virus1

Protection against Influenza Virus Infection of Mice Fed Bifidobacterium breve YIT4064

There must be a change in vaccine strategy to include immunization with both HA and NA to broaden the immune response against influenza. Inclusion of the more slowly evolving NA in a vaccine against influenza will reduce the vulnerability to antigenic changes in a potential emerging influenza virus

Efficacy of human leukocyte interferon against Hong Kong influenza treated:~7% sich vs. ~15% placebo

Killer Peptide May Offer New Therapy Against Influenza A Virus

In vivo experiments showed that G4-SA completely prevented infection by a H3N2 subtype in a murine influenza

[FrenchieGirl]

Re: some snippets from flu-papers found while googling

[Google Translation]

International

Flu: WHO interested by the Russian medication
16:08 | 29 / 07 / 2009

MOSCOW, July 29 - RIA Novosti. The World Health Organization (WHO) is interested in the Russian drugs for prophylaxis and treatment of influenza, announced Wednesday the press service of the Federal Service for Public Health Surveillance (Roszdravnadzor).

"By visiting the Institute for Research on Influenza of the Russian Academy of Medicine, we discovered with interest the existence of research in the field of application of a combination of interferon alpha and gamma for the treatment and prophylaxis of influenza, including influenza A/H1N1. This combination will be considered by WHO as a new drug, "reads a passage in a press release issued after a meeting between the director and Roszdravnadzor Nikolai Iourguel Director of the European office of WHO Marc Danzon.

Previously, Oleg Kisselev, director of the Institute for Research on Influenza, spoke to RIA Novosti the new drug and explained that unlike other means of struggle against the flu, this medication is intended to strengthen immunity. Composition, a combination of interferon alpha and gamma yields the best result in the treatment of influenza A/H1N1.

The drug is made in the form of drops, which facilitates its use. Its price in Moscow is about 300 rubles (7 euros). Previously, WHO recommended Tamiflu Switzerland, sold in pharmacies in Moscow 2000 rubles (45 euros).

[gsgs]

Re: some snippets from flu-papers found while googling

what's the name, is it available over the internet for privates ?

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could be Viferon or Grippferon, see:

http://en.wikipedia.org/wiki/Influenza_treatment

http://www.onlinepharmacy4u.co.uk/viferon-buy-online.htm

http://www.pharmacy1010.com/product_page.asp?id=1024

http://www.drugs-pro.com/antiviral-agents/viferon-1mln.html

http://www.rxprohub.com/brand/256/303/viferon-interferon-alfa-2b-acid-ascorbic-tocoferol

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1: Antibiot Khimioter. 2008;53(3-4):13-7. Links
[Viferon suppositories in the treatment of influenza in adults]
[Article in Russian]


Gatich RZ, Kolobukhina LV, Vasil'ev AN, Isaeva EI, Burtseva EI, Orlova TG, Voronina FV, Kol'tsov VD, Malinovskaia VV.
One hundred and one patients at the age of 18 to 60 years suffering from influenza were observed during increased ratio of the sickness due to the influenza virus types A (H1N1 and H3N2) and B. The diagnosis of influenza was confirmed by the laboratory tests. Viferon was used in the treatment of 35 patients. The randomized double blind placebo-controlled study revealed high therapeutic efficacy ofviferon and its immunomodulating effect on the T-cells, the neutrophil phagocytic activity and the decrease of the levels of the circulating immune complexes. Viferon and arbidol decreased the fever periods and the toxicosis symptoms vs. the placebo. The therapeutic efficacies of viferon and arbidol were on the whole comparable, whereas the clinical findings and the results of the immunological tests were evident of the viferon higher therapeutic and immunomodulating efficacy. No side effects of the drugs were recorded. The tolerability was excellent. Viferon can be recommended for the treatment of influenza in adults.

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Evaluation of the efficacy of wiferon and arbidol in adult influenza][Article in Russian]


Kolobukhina LV, Malinovskaia VV, Gatich RZ, Merkulova LN, Burtseva EI, Isaeva EI, Parshina OV, Guseva TS, Orlova TG, Voronina FV.
The therapeutic efficacy of wiferon (recombinant alpha2beta-interferon) versus arbidol was studied in a double-blind controlled study in patients with laboratorily verified influenza. Within the first 24-36 hours after the onset of the disease, wiferon and arbidol reduced the duration of fever, intoxication, and the catarrhal symptoms of the disease as a whole. The agents were shown to have an immunomodulating effect.

PMID: 18318133 [PubMed - indexed for MEDLINE]

[mixin]

Re: some snippets from flu-papers found while googling

There must be a change in vaccine strategy to include immunization with both HA and NA to broaden the immune response against influenza. Inclusion of the more slowly evolving NA in a vaccine against influenza will reduce the vulnerability to antigenic changes in a potential emerging influenza virus

The above quote was from a paper published over 2 years ago. Below is from the pandemic workshop last month. This sounds important; why aren't NA levels routinely checked?

Unfortunately, we don't have published levels of neuraminidase for other influenza vaccines; neuraminidase levels are not routinely checked. Neuraminidase mediates the removal of sialic acid on hemagglutinin.

[gsgs]

Re: some snippets from flu-papers found while googling

Aerosol transmission of influenza A virus: a review of new studies.
R. Tellier (2009)
J R Soc Interface 6, S783-S790

The effect of environmental parameters on the survival of airborne infectious agents.
J. W. Tang (2009)
J R Soc Interface 6, S737-S746

Surgical Mask vs N95 Respirator for Preventing Influenza Among Health Care Workers: A Randomized Trial.
M. Loeb, N. Dafoe, J. Mahony, M. John, A. Sarabia, V. Glavin, R. Webby, M. Smieja, D. J. D. Earn, S. Chong, et al. (2009)
JAMA 302, 1865-1871

Glycans on influenza hemagglutinin affect receptor binding and immune response.
C.-C. Wang, J.-R. Chen, Y.-C. Tseng, C.-H. Hsu, Y.-F. ****, S.-W. Chen, C.-M. Chen, K.-H. Khoo, T.-J. Cheng, Y.-S. E. Cheng, et al. (2009)
PNAS 106, 18137-18142

Preparing for pandemic (H1N1) 2009.
P. C. Hebert and N. MacDonald (2009)
Can. Med. Assoc. J. 181, E102-E103

Se preparer a la pandemie de grippe A H1N1 2009.
P. C. Hebert and N. MacDonald (2009)
Can. Med. Assoc. J. 181, E104-E105