Natto assists bird flu identification

[eladdie]

And if you have ever tasted natto, barf city, then you would say that you sincerely hope every last drop is used up too.

Better method found on detecting mutation of bird flu virus 6/4/2006 10:29

Genetic mutations in bird flu viruses could be monitored by a simple and inexpensive method using natto, or fermented soybeans, a Japanese research team announced on Tuesday.

Takashi Suzuki, a professor from the Shizuoka University's School of Pharmaceutical Sciences, said his research team jointly developed with its partners a new method to detect signals of the viruses' mutation into potentially new forms that could be transmitted from human to human.

In their experiment, adhesive substances in natto were used to fix cells from birds and humans on the surface of test plates, and viruses were then placed on the cells to check whether the form of the viruses has changed, the newspaper Yomiuri Shimbun reported on Wednesday

The method boasts higher sensitivity than conventional ones, Suzuki said.

http://english.eastday.com/eastday/englishedition/node20665/node20669/node22813/node95960/node95962/userobject1ai1963156.html

[Snowy Owl]

Re: Natto assists bird flu identification

Professor Takashi Suzuki Work from the Shizuoka University's School of Pharmaceutical Sciences

Many forms of life ranging from animal cells to bacteria or viruses possess sugar chains on their surface. Sugar chains show a diversity of structures that contain the unknowns at present. The sugar chains are related to many biologically important functions, such as blood types, fertilization, differentiation of a egg, organogenesis, cell proliferation, programed cell death, neurotransmission, differentiation of bone marrow cells to leukocytes or erythrocytes, immunoresponse of lymphocytes, and self or non-self recognition between different cells. Addition to that, sugar chains are involved in adhesion of leukocytes to endotherial cells in inflammatory diseases, metastasis of cancer, and also viral, bacterial, or protozoal infections.

As described above, we are interested in all life phenomena and diseases that may be associated with sugar chains, our studies going on in this line. Expression of sugar chains is controlled by enzymes which regulates the synthesis of sugar chains, and the regulation of the enzymes is controlled by genes coding the enzymes. It is a requisite region of the future of life sciences to decipher informations coded in sugar chains and those regulating genes. We are studying to make clear many informations of sugar chains involved in various life phenomena and various diseases at the levels of molecules and genes.

http://w3pharm.u-shizuoka-ken.ac.jp/pamphlet/biochem.html

1. Tadanobu Takahashi, Takashi Suzuki, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, Yasuo Suzuki, A molecukar mechanism for the low-pH atability of sialidase activity of influenza A virus N2 neuraminidase.

FEBS LETT., in press (2003)

　　2. Shinji Kojima, Teruaki Hasegawa, Takahiro Yonemura, Ken Sasaki, Kenji Yamamoto, Yutaka Makimura, Tadanobu Takahashi, Takashi Suzuki, Yasuo Suzuki, Kazukiyo Kobayashi, Ruthenium complexes carrying a disialo complex-type oligosaccharide: enzymatic synthesis and its application to a luminescent probe to defect influenza viruses.

Chem. Comm. DOI:10.1039/b210739b (2003)

(The Royal Society of Chemistry, Advance Article).

　　3. Yuko Matsushima-Hibiya, Masahiko Watanabe, Kazuya Hidari, Daisei Miyamoto, Yasuo Suzuki, Takeshi Kasama, Takashi Kanazawa, Kotaro Koyama, Takashi Sugimura, Keiji Wakabayashi, Identification of glycosphingolipid receptors for pierisin-1, a guanine-specific ADP-ribosylating toxin from the cabbage butterfly.

J. Biol. Chem. 278, 9972-9978 (2003)

　　4. Kazuhide Totani, Takeshi Kubota, Takao Huroda, Takeomi Murata, Kazuya I.-P. Jwa Hidari, Takashi Suzuki, Yasuo Suzuki, Kazukiyo Kobayashi, Hisashi Ashida, Kenji Yamamoto, and Taichi Usui: Chemoenzymatic synthesis and application of glycopolymers containing multivalent sialyloligosaccharides with a poly(L-glutamic acid) backbone for inhibition of infection by influenza viruses.

Glycobiology. (in press, 2003)

　　5.　Mitsuhiro Matsuda, Kenichi Shikata, Fujio Shimizu, Yasuo Suzuki, Masayuki Miyasaka, Hiroshi, Kawachi, Hiroto Kawashima, Jun Wada, Hikaru Sugimoto, Yasushi Shikata, Daisuke Ogawa, Shinichiro J. Tojo, Kazuo Akima, Hirofumi Makino: Therapeutic effect of sulphated hyaluronic acid, a potential selectin-blocking agent, on experimental progressive mesangial proliferative glomerulonephritis.

J. Pathol., 198, 407-414 (2002)

　　6. Rika Komagome, Hirofumi Sawa, Takashi Suzuki, Yasuo Suzuki, Shinya Tanaka, Walter J. Atwood, Kazuo Nagashima: Oligosaccharides as receptor for JC virus.

J. Virol., 76, 12992-13000 (2002)

　　7. D. Ogawa, K. Shikata, M. Matsuda, S. Okada, J. Wada, S. Yamaguchi, Y. Suzuki, M. Miyasaka, Preventive effect of sulfated colominic acid on P-selectin-dependent infiltration of macrophages on experimentally induced crescentic glomerulonephritis.

Clin. Exp. Immunol., 129, 43-53 (2002).

　　8. Chao-Tan Guo, Xue-Long Sun, Osamu Kanie, Kennedy Francis Shortridge, Takashi Suzuki, Daisei Miyamoto, Kazuya I.-P. Jwa Hidari, Chi-Huey Wong, and Yasuo Suzuki: An O-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses.

Glycobiol., 12, 183-190 (2002)

　　9. Kamruddlin Ahmed, Yasuo Suzuki, Daisei Miyamoto, Tsuyoshi Nagatake: Asialo-GM1 and Asialo-GM2 are putative adhesion molecules for Moraxella catarrhalis.

Med. Microbiol. Immunol. 191, 5-10 (2002)

10. Yasuo Suzuki: Receptor binding specificity and host range variation of influenza viruses (Review).

Recent Advances in Influenza Virus Res 2002., Ed., Y. Hayase,

Research Signpost, 161-168 (2002)

11. Hughes MT, McGregor M, Suzuki T, Suzuki Y, Kawaoka Y. Adaptation of influenza A viruses to cells expressing low levels of sialic acid leads neuraminidase activity.

J. Virol., 75 (8), 3766-3770 (2001).

12. Masafumi Kimura, Kazuya I.-P. Jwa Hidari, Takashi Suzuki, Daisei Miyamoto, Yasuo Suzuki. Engagement of endogenous ganglioside GM1a induces tyrosine phosphorylation involved in neuron-like differentiation of PC12 cells.

Glycobiology, 11 (4) 335-343 (2001).

13. Kiyoshi Ikeda, Kimihiko Sano, Masaki Ito, Kazuya idari, Takashi Suzuki, Yasuo Suzuki, Kiyoshi Tanaka, Synthesis of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid nalogues modified at the C-4 and C-9 positions and their behaviour towards sialidase from influenza virus and pig liver membrene.

Carbohydrate Res., 330, 31-41 (2001).

14. Takashi Suzuki, Allen Portner, Ruth Ann Scroggs, Makoto Uchikawa, Noriko Koyama, Kazuko Matsuo, Yasuo Suzuki, Toru Takimoto, Receptor specificities of human respiroviruses.

J. Virol.,75 (10), 46-4-4613 (2001).

15. Takashi Suzuki, Kiyoshi Ikeda, Noriko Koyama, Chika Hosokawa, Toshuhiro Kogure, Tadanobu Takahashi, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, Kiyoshi Tanaka,Yasuo Suzuki, Inhibition of human parainfluenza virus type 1 sialidase by analogs of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid.

Glycoconjugate J., 18, 331-337 (2001).

16. Tadanobu Takahashi, Yasuo Suzuki, Daisuke Nishimura, Nana Kawase, Yukiko Kobayashi, Kazuya I.-P. Jwa Hidari, Daisei Miyamoto, ChaoTan Guo, Kennedy F. Shortridge, Takashi Suzuki, Duck and Human Pandemic Influenza A viruses retain sialidase activity in Low pH conditions.

J. Biochem., 130 (2), 279-283 (2001).

17. Chao-Tan Guo, Shinji Ohta, Akihiro Yoshimoto, Kuniho Nakata, Kennedy F. Shortridge, Tadanobu Takahashi, Takashi Suzuki, Daisei Miyamoto, Kazuya I.-P. Iwa Hidari,Yasuo Suzuki, A unique phosphatidylinositol bearing a novel branched-chain fatty acid from Rhodococcus equi binds to influenza virus hemagglutinin and inhibits the infection of cells.

J. Biochem., 130, 377-384(2001).

18. Takehiko Saito, Wilina Lim, Takashi Suzuki, Yasuo Suzuki, Hiroshi Kida, Shin-Ichiro Nishimura, Masato Tashiro, Characterization of a human H9N2 influenza virus isolated in Hong Kong.

Vaccine , 20 (1-2), 125-133 (2001)

19. Yasuo Suzuki, Toshihiro Ito, Takashi Suzuki, Daisei Miyamoto, Kazuya I.-P. J. Hidari, Chao-Tan Guo, Hiroshi Kida, Robert G. Webster, Thomas M. Chambers, Yoshihiro Kawaoka, Sialyl sugar chains as receptors and determinants of host range of influenza A viruses.

Options for the control of Influenza IV Ed. A. Osterhaus, N. Cox, A. Hampson, Excerpta Media International Congress Series Published Elsevier Science B.V.

1219, 521-525 (2001)

20. Yasuo Suzuki, Toshihiro Ito, Takashi Suzuki, Robert E. Holland, Thomas M. Chambers, Makoto Kiso, Hideharu Ishida, Yoshihiro Kawaoka, Sialic acid species as a determinant of the host range of influenza A viruses.

J. Virol., 74 (24), 11825-11831 (2000).

21. Yasuo Suzuki: Host mediated variation and receptor binding specificity of influenza viruses.

The Molecular Immunoly of Complex carbohydrates 2 (Advances in Experimental Medicine and Biology) Vol. 491 (2001). Edited Albert M.Wu, Kluwer Academic/Plenum Publishers, New York, Boston, Dordrecht, London, Moscow (total 640 pages) pp.453-472 (2001).

21. Kuniho Nakata, Chao-Tan Guo, Motoko Matsufuji, Akihiro Yoshimoto, Masanori Inagaki, Ryuichi Higuchi, Yasuo Suzuki, Influenza A virus-binding activity of glyceroglycolipids of aquatic bacteria

J. Biochem., 127, 191-198 (2000).

22. Sayuri Miya****a, Yasumi Matsuura, Daisei Miyamoto, Yasuo Suzuki, Yasuyuki Imai, Development of recombinant B subunit of Shiga-like toxin 1 as a probe to detect carbohydrate ligands in immunochemical and flowcytometric application.

Glycoconjugate J., 16, 697-705 (2000).

23. Xue-Long Sun, Yoshimi Kanie, Chao-Tan Guo, Osamu Kanie, Yasuo Suzuki, Chi-Huey Wong, Synthesis of C-3 modified sialylglycosides as selective inhibotors of influenza hemagglutinin and neuraminidase.

Eur. J. Org. Chem., 2000, 2643-2653 (2000).

24. Toshihiro Ito,Yasuo Suzuki, Takashi Suzuki, Ayato Tanaka, Taisuke Horimoto, Krisna Wells, Hiroshi Kida, Koichi Otsuki, Makoto Kiso, Hideharu Ishida, Yoshihiro Kawaoka: Recognition of N-glycolylneuraminic acid linked to galactose by α2-3 linkage is associated with the intestinal replication of influenza A virus in ducks.

J. Virol., 73 (8) 6743-6751 (2000).

25. Akiko Eguchi, Toru Kondoh, Hirokazu Kosaka, Takashi Suzuki, Hiroshi Momota, Akinori Masago, Tetsuya Toshida, Hideharu Taira, Akiko Ishii-Watabe, Jun Okabe, Jianhong Hu, Naoyuki Miura, Shigeharu Ueda, Yasuo Suzuki, Takao Taki, Takao Hayakawa, Mahito Nakanishi, Identification and characterization of cell lines with a defect in a post-adsorption stage of Sendai virus-mediated membrane fusion.

J. Biol.Chem., 275 (23), 17549-17555 (2000).

26. Tetsuya Furuike, Seiich Aiba, Takashi Suzuki, Tadanobu Takahashi, Yasuo Suzuki, Kuriko Yamada, Shin-Ichiro Nishimura, Synthesis and anti-influenza virus activity of novel glycopolymers having triantennary oligosaccharide branches.

J. Chem. Soc. Perkin Trans. 1, 3000-3005 (2000).

27. Yuichi Kawai, Akira Takeiri, Takashi Suzuki, Yasuo Suzuki, Masaharu Miyake, Anti-mouse sperm monoclonal antibody, A-1, inhibits sperm capacitation, acrosome reaction and calcium influx into spermatocytes.

Biol. Pharm. Bull.23(8)922-925 (2000).

28. Yasuhiro Hosaka, Akihiro Ikeura, Yu-ichi Harada, Kazumichi Kuroda, Hideki Hamayasu, Takashi Suzuki, Kazunari Yamada, Yuji Kawase, Yasuo Suzuki.

Binding of influenza type A viruses to group B Streptococcus and haemagglutination by virus-bound bacteria.

J. Electron Microscopy 49(6) 765-773 (2000).

29. Kazuhiro Hayashi, Yuko M. Sagesaka, Takashi Suzuki, Yasuo Suzuki, Inactivation of human type A and B influenza viruses by tea-seed saponins

Biosci. Biotechnol. Biochem., 64(1), 184-186 (2000).

30. Yoshinao Kojima, Sstoshi Fukumoto, Keiko Furukawa, Tetsuya Okajima, Joelle Wiels, Keiko Yokoyama, Yasuo Suzuki, Takeshi Urano, Michio Ohta, Koichi Furukawa, Molecular cloning of globotriaosylceramide/CD77 synthesis, a glycosyltransferase that initiate the synthesis of globo series glycosphingolipids.

J. Biol. Chem., 275 (20), 15152-15156 (2000).

http://www.u-shizuoka-ken.ac.jp/~kijo4/P-54suzuki.y.htm

鈴木康夫（静岡県立大学・薬学部・生化学教室）


References (1) Toshihiro Ito, Yasuo Suzuki, Ayato Takada, Ayumi Kawamoto, Koichi Otsuki, Hiroyuki Masuda, Takashi Suzuki, Hiroshi Kida, Yoshihiro Kawaoka : Differences of sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection. J. Virol. 71(4), 3357-3362, 1997
(2) Takashi Suzuki, Goh Horiike, Yasuhiro Yamazaki, Kaoru Kawabe, Hiroyuki Masuda, Daisei Miyamoto, Masao Matsuda, Shin-Ichiro Nishimura, Tatsuya Yamagata, Toshihiro Ito, Hiroshi Kida, Yoshihiro Kawaoka Yasuo Suzuki : A Swine Influenza virus strains recognize sialylsugar chains containing the molecular species of sialic acid predominantly present in the swine tracheal epitherium. FEBS Lett. 404, 192-196, 1997
(3) Katsuhiko Sato, Goro Hanagata, Makoto Kiso, Akira Hasegawa, Yasuo Suzuki : Specificity of N1 and N2 sialidase subtypes of human influenza A virus for natural and synthetic gangliosides. Glycobiology, 8 (6), 527 - 532, 1998
(4) Hiroyuki Masuda, Takashi Suzuki, Yoshiyuki Sugiyama, Goh Horiike, Kohji Murakami, Daisei Miyamoto, Kazuya I-P. Jwa Hidari, Toshihiro Ito, Hiroshi Kida, Makoto Kiso, Kyoko Fukunaga, Masanobu Ohuchi, Tetsuya Toyoda, Akira Ishihama, Yoshihiro Kawaoka, Yasuo Suzuki : Substitution of amino acid residue in influenza A virus hemagglutinin affects recognition of sialyl-oligosaccharides containing N-glycolylneuraminic acid. FEBS LETT. 464, 71-74, 1999
(5) Kuniho Nakata, Chao-Tan Guo, Motoko Matsufuji, Akihiro Yoshimoto, Masanori Inagaki, Ryuichi Higuchi, Yasuo Suzuki : Influenza A virus- binding activity of glyceroglycolipids of aquatic bacteria. J. Biochem. 127, 191-198, 2000
(6) Yasuo Suzuki, T. Ito, O. Gao, K. Masuda, C-T. Guo, K. Hidari, D. Miyamoto, T. Suzuki, Y. Kawaoka : Host madiated variation of influenza viruses. Glycoconjugate J.16 (4/5), S39, 1999
(7) Darwin Kobasa, Shantha Kodihalli, Ming Luo, Maria R. Castrucci,Isabella Donateli, Yasuo Suzki, Takashi Suzuki, Yoshihiro Kawaoka : Amino acid residues contributiong to the substrate specificity of theinfluenza A virus neuraminidase. J. Virol. 73, 6743-6751, 1999
(8) Yasuo Suzuki, Toshihiro Ito, Takashi Suzuki, Robert E. Holland, Thomas M. Chambers, Makoto Kiso, Hideharu Ishida, Yoshihiro Kawaoka : Sialic acid species as a determinant of the host range of influenza A viruses. J. Virol. in press, 2000
(9) Toshihiro Ito,Yasuo Suzuki, Takashi Suzuki, Ayato Tanaka, Taisuke Horimoto, Krisna Wells, Hiroshi Kida, Koichi Otsuki, Makoto Kiso, Hideharu Ishida, Yoshihiro Kawaoka: Recognition of N-glycolylneuraminic acid linked to galactose by alpha 2-3 linkage is associated with the intestinal replication ofinfluenza A virus in ducks. J. Virol., 74 (19) 9300-9305, 2000


2000年 9月 15日

Guo CT, Takahashi T, Bukawa W, Takahashi N, Yagi H, Kato K, Hidari KI, Miyamoto D, Suzuki T, Suzuki Y. Related Articles, Links
Abstract Edible bird's nest extract inhibits influenza virus infection.
Antiviral Res. 2006 Mar 3; [Epub ahead of print]
PMID: 16581142 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Suzuki+T