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MSM::Detailed Flu Virus Pictures May Help Fight Possible Pandemic

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  • MSM::Detailed Flu Virus Pictures May Help Fight Possible Pandemic

    Detailed Flu Virus Pictures May Help Fight Possible Pandemic

    By John Lauerman
    Dec. 29 (Bloomberg) -- Scientists who took three- dimensional pictures of flu viruses for the first time said the detailed images may help fight a possible pandemic.
    The discovery may help scientists understand how flu finds and attacks vulnerable cells, and how protective human proteins called antibodies disable the virus, said scientists led by Alasdair Steven of the U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases in Bethesda, Maryland.
    The prospect of an influenza pandemic has spurred scientists to seek better data on how influenza changes forms to evade the immune system, causing outbreaks that kill as many as 500,000 people annually. A deadly flu virus as contagious as one that killed about 50 million people in 1918-1920 might kill as many as 81 million today, Harvard scientists said Dec. 22.
    ``Being able to visualize influenza virus particles should boost our efforts to prepare for a possible pandemic flu attack,'' Stephen Katz, the arthritis institute's director, said in an e-mailed statement today. ``This work will allow us to 'know our enemy' much better.''
    The government scientists, working with researchers from University of Virginia in Charlottesville, used an imaging method called electron tomography that makes pictures of microscopic structures in three dimensions. The detail was so fine that scientists were able to distinguish between three different flu strains in one sample, the statement said.


    http://www.bloomberg.com/apps/news?p...fer=healthcare

    {hat-tip to christian}
    http://novel-infectious-diseases.blogspot.com/

  • #2
    Re: MSM:etailed Flu Virus Pictures May Help Fight Possible Pandemic

    OK, here is one of the pictures:

    http://www.niams.nih.gov/ne/press/2006/flu-virus2.jpg




    who will hazard an explanation ?
    I assume the big colored ball is a flu-virus.
    What do the colors indicate ? Virus-segments ?
    I assume the coloring was done afterwards
    and shadows were added by hand.
    What are the 3-5 other, smaller grey balls ? also viruses ?
    How much is 0.1 micron on the picture ?
    It would be nice to see, how they distinguished the 3 strains.















    green:hemagglutinin (length:1707)
    yellow:neuraminidase (length:1350)
    blue:matrixprotein (length:986)
    total length:13088
    ?


    when I see it so in front of me, I wonder why I can't just
    squeeze this little monster.
    Would it work ? Say, You have 2 exact glass-plates, with viruses on them
    (maybe mirrors or optical glasses) and then you press them against each other.
    Would the viruses on them die ?
    Could we design hospital floors and cleaners accordingly ?
    For bacteria it might be possible... or not ?

    looking for a electron-microscopic picture of glass or metal surfaces now...

    ... I didn't find it with German keywords, maybe someone can help ?
    I'm interested in expert panflu damage estimates
    my current links: [url]http://bit.ly/hFI7H[/url] ILI-charts: [url]http://bit.ly/CcRgT[/url]

    Comment


    • #3
      Re: MSM:etailed Flu Virus Pictures May Help Fight Possible Pandemic

      ahh, I knew, I saw that picture before, but apparantly forgot it.

      see this thread:

      http://www.flutrackers.com/forum/showthread.php?t=14641


      -text under the picture:

      Photo Caption: The three-dimensional structure of influenza virus from electron tomography. The viruses are about 120 nanometers
      about one ten thousandth of
      a millimeter in diameter.
      I'm interested in expert panflu damage estimates
      my current links: [url]http://bit.ly/hFI7H[/url] ILI-charts: [url]http://bit.ly/CcRgT[/url]

      Comment


      • #4
        Re: MSM:etailed Flu Virus Pictures May Help Fight Possible Pandemic

        Originally posted by gsgs
        OK, here is one of the pictures:

        when I see it so in front of me, I wonder why I can't just
        squeeze this little monster.
        Would it work ? Say, You have 2 exact glass-plates, with viruses on them
        (maybe mirrors or optical glasses) and then you press them against each other.
        Would the viruses on them die ?
        ...and if we could only squish them inside our bodies.

        Do they use electical polarity to become attracted to human cells? What is it that attracts them to seek receptors? I know they can only fit in specific receptors--but what is the "attraction" that causes them to seek those receptors in the first place?

        Can that attraction be turned off?

        Comment


        • #5
          Re: MSM:etailed Flu Virus Pictures May Help Fight Possible Pandemic

          I guess, the attraction is pretty short range. Some areas of the
          virus-surface-HA "fits" to some areas on the cell-surface
          and when they come into contact a process is initiated
          which finally makes the virus entering the cell.
          So, it's not sufficient that the virus contacts the cell-membrane,
          also the correct regions must contact each other
          (I think)

          A cell is 10-100 micrometer in diameter, that's as long as 80-800
          of these viruses in a row.
          Someone knows, how dense these alpha2-3 receptors are distributed over the cell-surface ?
          And when the viruses leave a cell, they somehow travel in the
          intercellar space until they meet a new cell ?!?
          I'm interested in expert panflu damage estimates
          my current links: [url]http://bit.ly/hFI7H[/url] ILI-charts: [url]http://bit.ly/CcRgT[/url]

          Comment


          • #6
            Re: MSM:etailed Flu Virus Pictures May Help Fight Possible Pandemic

            looks as if these green pins are about 13nm apart, that gives
            about 256 pins with a virus-surface of 4*pi*(60nm)^2.

            HA has 560 amino-acids and 1700 nucleotides.
            I'd like to see these amino-acids and nucleotides in
            a (half-shematic, half-realistic) picture



            volume is ~900000(nm)^3 which would amount to 800 such "pins", or 4-5 nm
            diameter per nucleotide.
            The (HA-)surface had 250 pins. However HA has 560 aa and the whole virus
            has 4400. I wonder ehat these pins are and from what they are made
            Last edited by gsgs; December 31st, 2006, 04:41 AM.
            I'm interested in expert panflu damage estimates
            my current links: [url]http://bit.ly/hFI7H[/url] ILI-charts: [url]http://bit.ly/CcRgT[/url]

            Comment

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