Announcement

Collapse
No announcement yet.

Influenza virus receptors in the human air way.

Collapse
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

  • Influenza virus receptors in the human air way.

    <dl class="PubmedArticle" id="dlPubmedArticle17038816"><dt class="head" id="head17038816">1: Uirusu. 2006 Jun;56(1):85-9.<script language="JavaScript1.2"> <!-- var PopUpMenu2_LocalConfig_jsmenu3Config = [ ["ShowCloseIcon","yes"], ["Help","window.open('/entrez/query/static/popup.html','Links_Help','resizable=no,scrollbars= yes,toolbar=no,location=no,directories=no,status=n o,menubar=no,copyhistory=no,alwaysRaised=no,depend =no,width=400,height=500');"], ["TitleText"," Links "] ] var jsmenu3Config = [ ["UseLocalConfig","jsmenu3Config","",""] ] //--> </script> <script language="JavaScript1.2"> <!-- var Menu17038816 = [ ["UseLocalConfig","jsmenu3Config","",""], ["Books","window.top.location='http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=pubmed_AbstractPlus&cmd=Retrieve& db=pubmed&list_uids=17038816&dopt=Books'","",""] ] //--> </script> Links
    </dt><dd class="abstract" id="abstract17038816">Influenza virus receptors in the human air way.
    The Avian Zoonosis Research Centre, Tottori University (Associate Professor).
    Avian influenza A (H5N1) virus infections have resulted in more than 100 human deaths; yet, human-to-human transmission is rare. We demonstrated that the epithelial cells in the upper respiratory tract of humans mainly possess sialic acid linked to galactose by alpha 2,6 linkages (SAalpha 2,6Gal), a molecule preferentially recognized by human viruses. However, many cells in the respiratory bronchioles and alveoli possess SAalpha 2,3Gal, which is preferentially recognized by avian viruses. These facts are consistent with the observation that H5N1 viruses can be directly transmitted from birds to humans and cause serious lower respiratory tract damage in humans. Furthermore, this anatomical difference in receptor prevalence may explain why the spread of H5N1 viruses among humans is limited. However, since some H5N1 viruses isolated from humans recognize human virus receptors, additional changes must be required for these viruses to acquire the ability for efficient human-to-human transmission.
    PMID: 17038816 [PubMed - in process]
    </dd></dl>

  • #2
    Re: Influenza virus receptors in the human air way.

    the spread hunan to human seems to be much more efficient than
    bird to human. Much human exposure to sick birds with little infections,
    little exposure to sick humans but considerable infections in the clusters.

    The change from 2,3 to 2,6 doesn't look so complicated or difficult.
    We saw efficient h2h in H1,H2,H3 already with only slightly different
    receptor binding domains in HA.

    Let's hope that interaction of the genes is required to keep H5N1
    functioning and that a simple adaption of the RBD is not sufficient
    to cause a pandemic !

    H5N1 had not had so many opportunities yet to adapt the RBD.
    Those who argue that H5N1 might not be able to go pandemic
    since it hadn't done this for 9 years now should keep in mind
    that H5N1 just had had no opportunities yet to evolve and adapt
    in several generations of mammals.
    I'm interested in expert panflu damage estimates
    my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

    Comment


    • #3
      Re: Influenza virus receptors in the human air way.

      gsgs
      What are the numbers of b-h compared to h-h?

      Comment


      • #4
        Re: Influenza virus receptors in the human air way.

        Originally posted by AnneZ
        gsgs
        What are the numbers of b-h compared to h-h?
        I guess:

        probability that a sick bird infect a human in the same household
        ("pet"-chicken): 1:100

        probability that a sick human infects another human in the same
        household : 1:10
        I'm interested in expert panflu damage estimates
        my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

        Comment


        • #5
          Re: Influenza virus receptors in the human air way.

          How do you work these probabilities out?

          Comment


          • #6
            Re: Influenza virus receptors in the human air way.

            I wouldn't call it "work out". Just expressing my feelings in numbers rather than unclear words.

            Well, somehow looking at the numbers of infected humans
            and which percentage of these were in clusters.

            And trying to estimate the number of human-sick bird
            contacts and comparing with the number of human infections.

            BTW. I had a 1:1000 first for b2h but then edited that post.
            I'm interested in expert panflu damage estimates
            my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

            Comment


            • #7
              Re: Influenza virus receptors in the human air way.

              Originally posted by gsgs
              I wouldn't call it "work out". Just expressing my feelings in numbers rather than unclear words.

              Well, somehow looking at the numbers of infected humans
              and which percentage of these were in clusters.

              And trying to estimate the number of human-sick bird
              contacts and comparing with the number of human infections.

              BTW. I had a 1:1000 first for b2h but then edited that post.
              gsgs: I think you should re-edit your post back to the 1:1000 for the b2h.
              Generally speaking, the first guess is much more accurate than the second.
              (Just expressing my feelings in clear words)

              Comment

              Working...
              X