Originally posted by KBD
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Confirmation of Avian Influenza H7N2 Infection in Wales
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Re: Confirmation of Avian Influenza H7N2 Infection
Last edited by HenryN; May 29, 2007, 02:16 AM.
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Re: Confirmation of Avian Influenza H7N2 Infection
The first news release refers to H7N2 and specifies 4 persons. It could be badly written?
"...The Health Protection Agency is providing expert support and advice to the National Public Health Service for Wales after an H7N2 avian influenza infection was found in birds on a small farm in north Wales. The Agency has carried out tests on specimens from nine people associated with the incident; seven are from Wales and two were from north west England.
Four of the test results were positive - two of these were from Wales and two were from north west England.The remaining five test results came back as negative. However because these five cases were associated with the birds and had a compatible illness, they are being treated as a precaution.
H7N2 is a low pathogenic strain of avian flu...."
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Re: Confirmation of Avian Influenza H7N2 Infection
Hi. Looking at the latest update from the National Public Health Service for Wales http://www.wales.nhs.uk/sites3/news....contentid=6796 Only two tests for H7N2 so far have been positive. I know initially they said there were four positives. I'm just wondering whether these other two might have been positive for type-A flu, but not an H7 subtype..? KBD
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Re: Confirmation of Avian Influenza H7N2 Infection
Originally posted by niman View PostThat is incorrect. Both H5 and H7 can convert by adding or changing amino acids at the cleavage site.
There is no evidence that an H5/H7 reassortant would be bad.
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Re: Confirmation of Avian Influenza H7N2 Infection
Originally posted by Vibrant62 View PostH7 viruses are also a concern, becuase, like H5 viruses they can convert into highly pathogenic forms quite readily, but not as readily as H5 viruses. H7 viruses will only become more pathogenic when additional amino acids are added to the cleavage site, whereas LPAI H5 viruses can become HPAI viruses by either an addition of an amino acid to the cleavage site or by substitution of an amino acid within the existing cleavage site.
Just becase its not particularly 'bad' at present, does not mean it will remain that way.
An H7N2 reassortment with H5N1 could be very bad indeed.
There is no evidence that an H5/H7 reassortant would be bad.
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Re: Confirmation of Avian Influenza H7N2 Infection
H7 viruses are also a concern, becuase, like H5 viruses they can convert into highly pathogenic forms quite readily, but not as readily as H5 viruses. H7 viruses will only become more pathogenic when additional amino acids are added to the cleavage site, whereas LPAI H5 viruses can become HPAI viruses by either an addition of an amino acid to the cleavage site or by substitution of an amino acid within the existing cleavage site.
Just becase its not particularly 'bad' at present, does not mean it will remain that way.
An H7N2 reassortment with H5N1 could be very bad indeed.
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Re: Confirmation of Avian Influenza H7N2 Infection
Originally posted by cartski View PostThe article's abstract mentions the possibility of an H7 pandemic.
The acute respiratory distress syndrome brings back memories of SARS from a coronovirus.
So an H7 or any other strain of virus that creates a pandemic, plus another opportunistic virus, suggests a pandemic with localized fatal outbreaks before the development of a more severe, or new strain, pandemic.
That's different from the generaly assumed fowl-mammal-H2H local - H2H mass proliferation model.
FT is justified, therefore, in closely following the development of other viral diseases. (aside from humanitarian grounds)
J.
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Re: Confirmation of Avian Influenza H7N2 Infection
Originally posted by cartski View PostThe article's abstract mentions the possibility of an H7 pandemic.
The acute respiratory distress syndrome brings back memories of SARS from a coronovirus.
So an H7 or any other strain of virus that creates a pandemic, plus another opportunistic virus, suggests a pandemic with localized fatal outbreaks before the development of a more severe, or new strain, pandemic.
That's different from the generaly assumed fowl-mammal-H2H local - H2H mass proliferation model.
FT is justified, therefore, in closely following the development of other viral diseases. (aside from humanitarian grounds)
J.
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Re: Confirmation of Avian Influenza H7N2 Infection
Originally posted by vinny View PostAvian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
link to the full article is below,not sure if this helps sorry if im barking up the wrong tree.
http://www.pubmedcentral.nih.gov/art...i?artid=337057
The acute respiratory distress syndrome brings back memories of SARS from a coronovirus.
So an H7 or any other strain of virus that creates a pandemic, plus another opportunistic virus, suggests a pandemic with localized fatal outbreaks before the development of a more severe, or new strain, pandemic.
That's different from the generaly assumed fowl-mammal-H2H local - H2H mass proliferation model.
FT is justified, therefore, in closely following the development of other viral diseases. (aside from humanitarian grounds)
J.
Leave a comment:
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Re: Confirmation of Avian Influenza H7N2 Infection
Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
link to the full article is below,not sure if this helps sorry if im barking up the wrong tree.
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Re: Confirmation of Avian Influenza H7N2 Infection
Originally posted by Commonground View PostI'm starting to write down the cases.
I have positive: The pupil today, 2 from Wales and 2 from N. England. No names. Is that correct?
If I had to guess, I would say the child's parent is the local vet who called in reinforcements (from north west England), so the four cases would be the vet and child from Wales, and two investigators from north west England.
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Re: Confirmation of Avian Influenza H7N2 Infection
Originally posted by gsgs View Postif H7 or H5 wanted to recombine, it looks more natural they
would do it with other H7 or H5, not mixed.
They can not gain much by mixing.
If there are single-nucleotide-"recombination" (IMO random mutations),
then why don't we
see longer (2,3,..)-nucleotide-changes-recombinations ?
H5N1 knows how the game is played, and the story is VERY clear in the sequences.
Here it is color coded. Position 754.
White = H7N3
Blue = H5N1
Gold is wild type (230 is M)
If you are not color blind, it is an easy call
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Re: Confirmation of Avian Influenza H7N2 Infection
if H7 or H5 wanted to recombine, it looks more natural they
would do it with other H7 or H5, not mixed.
They can not gain much by mixing.
If there are single-nucleotide-"recombination" (IMO random mutations),
then why don't we
see longer (2,3,..)-nucleotide-changes-recombinations ?
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Re: Confirmation of Avian Influenza H7N2 Infection
Originally posted by Niko View PostIf H7N2 were to combine with H5N1, would it result in a new (H?N?) avian influenza virus or would it be a new strain of H7N2 or H5N1? How different would the recombined virus need to be in order to be reclassified as a new virus? Please explain answer in lay terms, as much as possible. Thank you!
In the past I described the concurrent acquistion by a single nucleotide polymorphisms (the difference of one letter) onto multiple genetic backgrounds in Egypt, Russia, and Ghana. In each case the single nucleotide was appeneded onto the genetic background in the given region. This addition was on 11 sequences representing 6 H5N1 backgrounds.
The same thing happened with M230I. In one series, the sequencing encoding the M230I on the H5N1 in Egypt matched the sequence in H7N3, so the acquisition of M230I involve a single nucleotide and the the amino acid at position 230 changed from M to I.
It is this type of change that would convert H5N1 to a more efficient transmitter. In Egypt, there were 5 human isolates with M230I (4 had the coding seen in H5N1 in Germany, and 1 had the coding seen in H7N3 seen in England last year). There were also H5N1 poultry isolates with M230I. Most had the version seen in H7N3.
In addition to the efficient transmission in the Gharbiya cluster, all human cases with H5N1 containing M230I were fatal.Last edited by HenryN; May 28, 2007, 03:46 PM.
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Re: Confirmation of Avian Influenza H7N2 Infection
I'm starting to write down the cases.
I have positive: The pupil today, 2 from Wales and 2 from N. England. No names. Is that correct?
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