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Russia - Government says "high incidence" of flu is due to H1N1pdm09 mutation not covered by vaccine - January 26, 2016 - issues press release for damage control saying "conventional drift"

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  • Russia - Government says "high incidence" of flu is due to H1N1pdm09 mutation not covered by vaccine - January 26, 2016 - issues press release for damage control saying "conventional drift"


    In Russia, died from the flu 50 people, a high incidence is related to a mutation of the H1N1 virus Society January 26th, 16:19 UTC + 3, 24 people died this week, said Head of the Laboratory of Biotechnology and Research Institute of Influenza diagnostic preparations


    PETERSBURG, January 26. / Correspondent. Natalia Mihalchenko TASS /. High morbidity and mortality from influenza in certain regions of Russia is associated with a mutation of the virus H1N1 (Swine Flu). This was reported by TASS Head of the Laboratory of Biotechnology and Research Institute of Influenza diagnostic preparations Anna Sominina.

    Total of 50 Russians died of influenza, including 24 this week," - she said. "Among the isolated and studied in laboratories around 40% of viruses are changes in the genome that do not contain the vaccine. All in all today was able to identify three mutations" - added Sominina. According to the Institute of influenza in the country weekly epidemic threshold was exceeded by 48.8%, the baseline - 32%. Among the types of circulating influenza virus H1N1 predominant (96%).


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  • #2
    from the Russia state influenza surveillance report for week 3 (January 11 - January 17, 2016)

    machine translation



    Conclusion


    Influenza and ARI morbidity data. Increase of influenza and other ARI activity was registered during the week 03.2016 in traditional surveillance system in Russia. The nationwide ILI & ARI morbidity level (60.6 per 10 000 of population) was lower than the national baseline by 12.8%.

    Etiology of ILI & ARI morbidity. The overall proportion of respiratory samples positive for influenza was estimated as 25.3%. Percent of positive ARI cases of non-influenza etiology (PIV, adeno- and RSV) was estimated as 22.2% of investigated patients by IFA and 16.0% by PCR.

    Antigenic characterization. Totally 45 influenza A(H1N1)pdm09 and 2 A(H3N2) viruses were characterizated antigenically in two NICs of Russia since the beginning of the season. 35 (76.6%) influenza A(H1N1)pdm09 strains were related closely to influenza A/California/07/09 virus, 10 (23.4%) influenza A(H1N1)pdm09 viruses had decreased up to 1/16 titers. Two A(H3N2) strains were similar to influenza A/Hong-Kong/4801/2014 virus but reacted with antiserum to influenza A/Switzerland/9715293/2013 vaccine strain up to 1/4 - 1/8 of homological titer only.

    Genetic characterization. Three influenza A(H1N1)pdm09 viruses were identical for 97.8% to A/California/07/09 virus and for 99.0% to influenza A/South Africa/3626/13 virus. All investigated strains had substitutions S84N, S162N+ and I216T in HA.

    In sentinel surveillance system clinical samples from 57 SARI and 50 ILI/ARI patients were investigated by rRT-PCR. 24 (35.6%) influenza SARI cases were detected including 21 influenza A(H1N1)pdm09, 1 influenza A(H3N2) and 2 influenza B cases. 5 (10.0%) influenza ILI/ARI cases were detected including 4 influenza A(H1N1)pdm09 and 1 influenza A(H3N2) cases.

    http://www.influenza.spb.ru/en/influ...mic_situation/



    Comment


    • #3
      A clarification of the above report......


      Press Release: Influenza epidemic situation on 01.27.2016
      PRESS RELEASE
      The epidemiological situation of influenza on 01/27/2016

      The rise of the incidence of influenza began with the 2nd week of 2016 in the Volga region (Volgograd, Rostov-on-Don, Stavropol) and has now exceeded the epidemic threshold fixed in 47 regions of the Russian Federation in all federal districts, except the Crimean Federal District.

      At the present time (4 weeks. Years) the incidence of influenza and SARS on the population of the Russian Federation as a whole was 91.6 cases of flu and colds by 10 thousand. People., Which is higher than the baseline for Russia (69.5 cases) 31.8% and epidemiological week. threshold (61.8) 48.2%.
      This week, compared with the previous week, the incidence observed in the cities of Russia continued to grow. The incidence of influenza and SARS on the European criteria relating to the mean intensity of the epidemic.

      The geographical spread of the flu in Russia as a whole and in all districts widespread, except for Siberia, where the spread of influenza corresponds to the regional level.

      The etiological structure of influenza overwhelming place is the virus that caused the pandemic of 2009 - A (H1N1) pdm09. A feature of the virus is higher pathogenicity for humans compared with other influenza viruses. However, the incidence rises caused by the influenza A (H1N1) pdm09 since 2009 are regular and are not something special or unforeseen.

      The greatest danger is the flu for people with reduced immunity, the elderly and people with chronic diseases. It was found that among the dead from the flu and its complications are no persons vaccinated against influenza.

      In this regard, appeared in the media with reference to the State Organization "Institute of Influenza" Russian Ministry of Health information about the high incidence of influenza in the current epidemic season is associated with mutations in the genome of circulating virus A (H1N1) pdm09, to inform you that this information does not correspond to reality.

      According to a preliminary molecular genetic analysis of circulating influenza A (H1N1) pdm09 antigenic properties and nucleotide sequences correspond to the vaccine strain A / California / 7/09. The genomes examined to date strains indeed several mutations have been identified, but they are not associated with high pathogenicity, and are probably the result of conventional genetic drift.

      The genome studied to date strains indeed found several mutations, but they are not associated with high pathogenicity, and are due to normal genetic drift, which is of interest only to specialists, virologists.

      FGBI "Influenza Research Institute" Russian Ministry of Health reminds you of the need for timely treatment to the doctor in the case of the first symptoms of the disease.

      hat tip @BVance
      for the link




      machine translation


      Comment


      • #4
        Originally posted by sharon sanders View Post
        In Russia, died from the flu 50 people, a high incidence is related to a mutation of the H1N1 virus Society January 26th, 16:19 UTC + 3, 24 people died this week, said Head of the Laboratory of Biotechnology and Research Institute of Influenza diagnostic preparations


        PETERSBURG, January 26. / Correspondent. Natalia Mihalchenko TASS /. High morbidity and mortality from influenza in certain regions of Russia is associated with a mutation of the virus H1N1 (Swine Flu). This was reported by TASS Head of the Laboratory of Biotechnology and Research Institute of Influenza diagnostic preparations Anna Sominina.

        Total of 50 Russians died of influenza, including 24 this week," - she said. "Among the isolated and studied in laboratories around 40% of viruses are changes in the genome that do not contain the vaccine. All in all today was able to identify three mutations" - added Sominina. According to the Institute of influenza in the country weekly epidemic threshold was exceeded by 48.8%, the baseline - 32%. Among the types of circulating influenza virus H1N1 predominant (96%).


        machine translation




        TASS is owned by the Russian government so I am not sure what is going on. link


        Russian News Agency TASS (Russian: Информационное агентство России ТАСС,Informatsionnoye agentstvo Rossii TASS), abbr. TASS, word Tass (Russian: ТАСС, Tass), is a major news agency in Russia, founded in 1902. Tass is owned by the government of Russia.[1] Headquartered in Moscow, the agency has 70 offices in Russia and CIS, as well as 68 bureaus around the world.
        Its Russian full official name is Federal State Unitary Enterprise ?Information Telegraph Agency of Russia (ITAR-TASS)? (Russian: Федеральное государственное унитарное предприятие ?Информационное телеграфное агентство России (ИТАР-ТАСС)?,Federal'noye Gosudarstvennoye Unitarnoye Predpriyatye ?Informatsionnoye telegrafnoye Agentsvo Rossii (ITAR-TASS)?),[2][3] shortly FGUP ?ITAR-TASS? (Russian: ФГУП ?ИТАР-ТАСС?). In 2014 under new brand policy it was rebraned as Information Agency of Russia ?TASS? (Russian: Информационное агентство России ?ТАСС?)[4] or Russian News Agency TASS in English. ITAR means Information Telegraph Agency of Russia,TASS means Telegraph Agency of the Soviet Union.

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