New case of H7 bird flu in Oxfordshire

[Diane Morin]

Re: Angleterre: H7 confirm? dans le Oxfordshire

Traduction automatique

Risque de grippe aviaire bas mais vrai

Nouvelles | 11 juillet 2008

Le risque d'un autre incident de la grippe aviaire est bas mais les gardes de volaille doivent rester vigilants, le sous-chef le vétérinaire qu'a averti.

Defra a aujourd'hui édité un rapport final d'épidémiologie dans la dernière manifestation confirmée dans Oxfordshire le 4 juin, cela conclut l'infection a été confiné à des lieux simples, et il n'y a aucune évidence d'une propagation de l'infection à aucun autre lieu.

Le vétérinaire sous-chef, Alick Simmons, a dit :

Cet incident a démontré encore le potentiel pour que l'influenza aviaire soit présentée dans la volaille domestique au R-U.
Le risque d'autres d'incidents, tandis que bas, demeure. J'invite des gardes de volaille à maintenir les niveaux les plus élevés du biosecurity et à rapporter le soupçon de la maladie promptement comprenant où les disques indiquent la mortalité accrue ou l'exécution réduite. ”

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Avian flu risk low but real

News | 11 July, 2008

THE risk of another incident of avian flu is low but poultry keepers must remain vigilant, the deputy chief veterinary officer has warned.

Defra today published a final epidemiology report into the last outbreak confirmed in Oxfordshire on June 4, that concludes the infection was confined to a single premise, and there is no evidence of a spread of infection to any other premises.
Deputy Chief Veterinary Officer, Alick Simmons, said:

“This incident has demonstrated again the potential for avian influenza to be introduced into domestic poultry in the UK.
“The risk of further incidents, while low, remains. I urge poultry keepers to maintain the highest standards of biosecurity and to report suspicion of disease promptly including where records indicate increased mortality or reduced performance.”

http://www.farmersguardian.com/story.asp?sectioncode=1&storycode=19928&c=1

[Giuseppe]

Re: New case of H7 bird flu in Oxfordshire

INFORMATION BULLETIN - Ref: 222/08
Date: 11 July 2008 - Nobel House, 17 Smith Square, London SW1P 3JR
Out of hours telephone 020 7270 8960

Avian influenza - Final epidemiology report published

Defra has today published a final epidemiology report into the Avian Influenza outbreak confirmed in Oxfordshire on 4 June.

The report concludes that at the time of writing (2 July) infection was confined to a single premise, and there is no evidence of infection on any contact or geographically close premises, or evidence of spread of infection to any other premises to date

While it has not been possible to conclusively identify the source of the infection, the two most likely sources of the outbreak are thought to be:

* Unidentified Avian Influenza in domestic premises in Great Britain, associated either by proximity or potential contact, or

* Avian Influenza in wildlife in contact with the IP

Investigations are now complete.

Deputy Chief Veterinary Officer, Alick Simmons, said
''This incident has demonstrated again the potential for avian influenza to be introduced into domestic poultry in the UK. The risk of further incidents, while low, remains. I urge poultry keepers to maintain the highest standards of biosecurity and to report suspicion of disease promptly including where records indicate increased mortality or reduced performance.''

Notes to Editors
1. The report can be viewed at www.defra.gov.uk/animalh/diseases/notifiable/disease/ai/latest-situation/index.htm
2. Advice and information on H7N7 avian influence is available via the Defra Helpline on 08459 33 55 77. Poultry keepers can also call the Animal Health recorded information line for the latest updates, on 0844 884 4600.
3. The Surveillance Zone and remaining disease control restrictions put in place following the outbreak of H7N7 avian Influenza in Oxfordshire were lifted on 8 July. The Protection Zone was lifted on 29 June. Some restrictions on trade with other countries remain. Further information is available at www.defra.gov.uk/animalh/int-trde/cins/2008/08115.htm
4. Avian Influenza is a disease of birds and whilst it can pass very rarely and with difficulty to humans, this usually requires extremely close contact with infected birds, particularly faeces. As a precautionary measure those who might have been exposed would be offered the appropriate treatment and protection in line with established protocols. Advice from the Food Standards Agency remains that properly cooked poultry and poultry products, including eggs, are safe to eat.
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Complete Report http://www.defra.gov.uk/animalh/dise...ort-080711.pdf
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http://www.defra.gov.uk/news/2008/080711b.htm

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[gsgs]

Re: New case of H7 bird flu in Oxfordshire

no sequences from Britain.

Now we have the bird-index, so we know some indication
how to distinguish wild-bird flu from chicken-flu.

We had the H7N7 in Netherlands 2003, which was very close to the
bird-index, closer than anything else in humans.
Humans got conjunctivitis, which is unusual. One vet died after
developing E627K.
This could be a strain closely related to mallards, waterborne transmission,
maybe that's the reason for the conjunctivitis.

It's important to study how these original-flu strains adapt to humans
or poultry. Please give us the sequences.

                             000000 0 0000 000 00 0000 0 00 
                             002356 0 3556 014 01 3344 2 01 
                             079562 5 9346 141 50 0445 7 83 
                             997537 4 1536 336 25 8628 3 57 
                             ------ - ---- --- -- ---- - -- 
                             DSIRQE K KHLL IAK YV NATP S PI 
>A/Index/birds/2000(H3N8a)   ...... . .... ... .. .... . .. 
>A/NL/219/03(H7N7)           YI.KRK R RYI. STR HM SVAS N L. 
>A/Ck/NL/1/03(H7N7)          Y.V... R RYIF ... HM .... N LV 
>A/Ck/NL/03010132/2003(H7N7) YI.KR. R RYI. ST. HM SVAS N L.


D9Y(PB2),S79I(PB2),R355K(PB2),Q563R(PB2),E627K(PB2)
K54R(PB1)
K391R(PA),H535Y(PA),L543I(PA)
I13S(HA),A143T(HA)
Y52H(NP),V105M(NP)
N308S(NA),A346V(NA),A442T(NA),P458S(NA)
S19N(M2)
P85L(NS1)

E627K(PB2),K54R(PB1),V105M(NP), in 1918flu



K54R(PB1) in birds:

R >A/Dk/Perak/2458/1989(H3N8),1989,10,2,5
R >A/Ck/HK/220/97(H5N1),1997,1,2,17
R >A/teal/HK/W312/97(H6N1),1997,8,2,18
R >A/parakeet/Chiba/1/97(H9N2),1997,0,2,19
...
R >A/Ck/Karachi/NARC-100/04(H7N3),2004,1,2,10
R >A/shoveler/Netherlands/19/99(H11N9),1999,11,3,2
R >A/Netherlands/219/03(H7N7),2003,0,3,1
R >A/Eurasian widgeon/Sweden/1/04(H6N2),2004,16,3,3
R >A/mallard/Italy/299/05(H7N7),2005,3,3,4
R >A/mallard/Sweden/45/05(H2N3),2005,3,3,3
R >A/blue Gs/WI/711/1975(H5N2),1975,15,4,7
N >A/canvasback Dk/ALB/102/1976(H3N6)08/13,1976,10,4,3
E >A/Dk/LA/17G/1987(H3N8),1987,10,4,17
R >A/mallard/Minnesota/371/98(H4N2),1998,3,4,3
R >A/Ck/Guatemala/45511-1/00(H5N2),2000,1,4,8
R >A/red knot/DE/1587/01(H10N7),2001,0,4,2
R >A/Northern shoveler/NC/6412-052/05(H7N6),2005,11,4,2
Q >A/green-winged teal/Minnesota/Sg-00228/06(H6N8)09/30,2006,8,4,4
R >A/cinnamon teal/CA/HKWF1111/07(H5N7)12/02,2007,8,4,5
R >A/ruddy turnstone/New Jersey/Sg-00516/08(H10N7)05/28,2008,9,4,6
R >A/ruddy turnstone/Delaware/Sg-00538/08(H1N5)05/31,2008,9,4,5
R >A/N.pintail/South Dakota/Sg-00456/08(H6N1)08/22,2008,6,4,5
R >A/mallard/Minnesota/Sg-00462/08(H6N1)09/16,2008,3,4,4
R >A/mallard/Minnesota/Sg-00464/08(H6N1)09/16,2008,3,4,4
R >A/red-necked stint/AUS/5745/1981(H12N9)03/05,1981,5,5,12
54 gsbi2.p13 100 E:10 K:2564 N:4 Q:1 R:85

E627K(PB2) in birds:

V >A/Tk/Israel/90710/00(H9N2),2000,2,2,13
K >A/Bar-h Gs/Qinghai/59/05(H5N1),2005,15,2,12
...
K >A/Dk/HK/702/1979-Qa adapted(H9N2),2000,10,2,10
G >A/Ck/Guangxi/4/99(H9N2),1999,1,2,25
K >A/tree sparrow/THA/VSMU-16-RBR/05(H5N1),2005,0,2,7
K >A/Ck/Italy/5093/99(H7N1),1999,1,3,8
K >A/Netherlands/219/03(H7N7),2003,0,3,5
G >A/mallard Dk/ALB/322/1988(H1N1),1988,3,4,4
K >A/laughing gull/NJ/276/1989(H6N8),1989,7,4,5
K >A/emu/TX/39924/1993(H5N2),1993,0,4,13
K >A/Ck/NY/21665-73/98(H1N1),1998,1,4,40
627 gsbi1.p13 212 A:1 E:2148 G:2 K:166 S:1 V:42

V105M(NP) in birds: many
...
105 gsbi5.p13 1578 A:5 H:1 I:90 K:3 L:4 M:1014 T:10 V:1465



54R(PB1) was in 1918flu and in early human H1N1, but swine had 54K.
7 birds have similar sequences to 1918flu in PB1 one of them has 54R :
blue goose/Wisconsin/711/1975
geese are more poultry-like, flu-wise

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deleted:
Now Cancun made the human 54R, besides other mutations whose meaning is unclear.
I had confused that with V105M(NP)