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First case of confirmed congenital Zika syndrome in continental Africa

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  • First case of confirmed congenital Zika syndrome in continental Africa

    Trans R Soc Trop Med Hyg. 2018 Jul 25. doi: 10.1093/trstmh/try074

    Abstract

    BACKGROUND:

    Zika virus has been responsible for recent outbreaks in the western hemisphere with known neurological complications such as microcephaly. This complication has not been previously documented in continental Africa.

    METHODS:

    Neurological evaluation of the newborn was performed after birth, at one and two months of age. The mother and the newborn sera samples were tested by immunofluorescent assay (IFA; immunoglobulin G [IgG] and IgM) for Zika virus and the presence of Zika virus ribonucleic acid (RNA) was checked by qualitative real-time reverse transcription polymerase chain reaction (RT-PCR) in placenta, blood and urine samples.

    RESULTS:

    We report on a newborn, born in Portugal, with microcephaly with confirmed congenital Zika virus infection (Asian lineage) imported from Angola with typical clinical and imaging findings.

    CONCLUSIONS:

    To our knowledge this is the first report that shows the circulation of the Asian lineage in Angola and the first report of a congenital Zika syndrome in continental Africa.

    Trans R Soc Trop Med Hyg. 2018 Jul 25. doi: 10.1093/trstmh/try074. [Epub ahead of print]
    “Addressing chronic disease is an issue of human rights – that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~
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