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Vect Borne Zoo Dis. Persistence of Anti-West Nile Virus-Specific Antibodies Among Asymptomatic Blood Donors in Northeastern Italy
[Source: Vector Borne and Zoonotic Diseases, full page: (LINK). Abstract, edited.]
Vector-Borne and Zoonotic Diseases
Persistence of Anti-West Nile Virus-Specific Antibodies Among Asymptomatic Blood Donors in Northeastern Italy
Anna Pierro,<SUP>1</SUP> Paolo Gaibani,<SUP>1</SUP> Claudia Manisera,<SUP>1</SUP> Giada Rossini,<SUP>1</SUP> Alba Carola Finarelli,<SUP>2</SUP> Florio Ghinelli,<SUP>3</SUP> Pierluigi Macini,<SUP>2</SUP> Maria Paola Landini,<SUP>1</SUP> and Vittorio Sambri<SUP>1</SUP>. Vector-Borne and Zoonotic Diseases. -Not available-, ahead of print. doi:10.1089/vbz.2012.1157.
Online Ahead of Print: August 6, 2013
Author information: <SUP>1</SUP>Regional Reference Centre for Microbiological Emergencies (CRREM), of the Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital, Bologna.<SUP>2</SUP>Public Health Authority Emilia-Romagna, Bologna, Italy. <SUP>3</SUP>Ferrara Blood Donor Association (AVIS), Ferrara, Italy. Address correspondence to: Anna Pierro, Unit of Clinical Microbiology, Regional Reference Centre for Microbiological Emergencies (CRREM), St. Orsola-Malpighi University Hospital, via Massarenti 9, 40138, Bologna, Italy, E-mail: anna.pierro@aosp.bo.it
ABSTRACT
The development and persistence of anti-West Nile Virus (WNV) immunoglobulin G (IgG)- and IgM-specific antibodies were investigated in 68 asymptomatic blood donors (BDs) previously tested as positive between October, 2008, and September, 2009, and living in northeastern Italy. Our study showed that WNV-specific IgG titers became negative (41%) or decreased (33%) in a large percentage of BDs, while they increased in a smaller percentage (10%); 16% of BDs showed no titer variation. Reversion to seronegative status within a short time frame suggests that WNV surveillance should be maintained year after year.
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Vector-Borne and Zoonotic Diseases
Persistence of Anti-West Nile Virus-Specific Antibodies Among Asymptomatic Blood Donors in Northeastern Italy
Anna Pierro,<SUP>1</SUP> Paolo Gaibani,<SUP>1</SUP> Claudia Manisera,<SUP>1</SUP> Giada Rossini,<SUP>1</SUP> Alba Carola Finarelli,<SUP>2</SUP> Florio Ghinelli,<SUP>3</SUP> Pierluigi Macini,<SUP>2</SUP> Maria Paola Landini,<SUP>1</SUP> and Vittorio Sambri<SUP>1</SUP>. Vector-Borne and Zoonotic Diseases. -Not available-, ahead of print. doi:10.1089/vbz.2012.1157.
Online Ahead of Print: August 6, 2013
Author information: <SUP>1</SUP>Regional Reference Centre for Microbiological Emergencies (CRREM), of the Operative Unit of Clinical Microbiology, S. Orsola-Malpighi University Hospital, Bologna.<SUP>2</SUP>Public Health Authority Emilia-Romagna, Bologna, Italy. <SUP>3</SUP>Ferrara Blood Donor Association (AVIS), Ferrara, Italy. Address correspondence to: Anna Pierro, Unit of Clinical Microbiology, Regional Reference Centre for Microbiological Emergencies (CRREM), St. Orsola-Malpighi University Hospital, via Massarenti 9, 40138, Bologna, Italy, E-mail: anna.pierro@aosp.bo.it
ABSTRACT
The development and persistence of anti-West Nile Virus (WNV) immunoglobulin G (IgG)- and IgM-specific antibodies were investigated in 68 asymptomatic blood donors (BDs) previously tested as positive between October, 2008, and September, 2009, and living in northeastern Italy. Our study showed that WNV-specific IgG titers became negative (41%) or decreased (33%) in a large percentage of BDs, while they increased in a smaller percentage (10%); 16% of BDs showed no titer variation. Reversion to seronegative status within a short time frame suggests that WNV surveillance should be maintained year after year.
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