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The Lancet Resp Med. Diet and asthma: vitamins and methyl donors
[Source: The Lancet Respiratory Medicine, full page: (LINK). Abstract, edited.]
The Lancet Respiratory Medicine, Early Online Publication, 31 July 2013
doi:10.1016/S2213-2600(13)70126-7
Copyright ? 2013 Elsevier Ltd All rights reserved.
Diet and asthma: vitamins and methyl donors
Original Text
Yueh-Ying Han PhD a ?, Josh Blatter MD a ?, John M Brehm MD a, Erick Forno MD a, Augusto A Litonjua MD b, Prof Juan C Celed?n MD a
Summary
Diet changes can partly explain the high burden of asthma in industrialised nations. Findings from experimental studies have stimulated many observational studies of the association between vitamins (A, C, D, and E) or nutrients acting as methyl donors (folate, vitamin B12, and choline) and asthma. However, observational studies are susceptible to several sources of bias; well conducted randomised controlled trials (RCTs) are the gold standard to establish whether diet has an effect on asthma. Evidence from observational studies and a few RCTs strongly justifies ongoing and future RCTs in three areas: vitamin D for the prevention or treatment of asthma, choline supplementation as adjuvant treatment for asthma, and vitamin E to prevent the detrimental effects of air pollution in patients with asthma. At present, insufficient evidence exists to recommend supplementation with any vitamin or nutrient acting as a methyl donor to prevent or treat asthma.
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a Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA; b Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Correspondence to: Prof Juan C Celed?n, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Suite 9130, Rangos Building, Pittsburgh, PA 15224, USA
? Authors contributed equally to the manuscript
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The Lancet Respiratory Medicine, Early Online Publication, 31 July 2013
doi:10.1016/S2213-2600(13)70126-7
Copyright ? 2013 Elsevier Ltd All rights reserved.
Diet and asthma: vitamins and methyl donors
Original Text
Yueh-Ying Han PhD a ?, Josh Blatter MD a ?, John M Brehm MD a, Erick Forno MD a, Augusto A Litonjua MD b, Prof Juan C Celed?n MD a
Summary
Diet changes can partly explain the high burden of asthma in industrialised nations. Findings from experimental studies have stimulated many observational studies of the association between vitamins (A, C, D, and E) or nutrients acting as methyl donors (folate, vitamin B12, and choline) and asthma. However, observational studies are susceptible to several sources of bias; well conducted randomised controlled trials (RCTs) are the gold standard to establish whether diet has an effect on asthma. Evidence from observational studies and a few RCTs strongly justifies ongoing and future RCTs in three areas: vitamin D for the prevention or treatment of asthma, choline supplementation as adjuvant treatment for asthma, and vitamin E to prevent the detrimental effects of air pollution in patients with asthma. At present, insufficient evidence exists to recommend supplementation with any vitamin or nutrient acting as a methyl donor to prevent or treat asthma.
________
a Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA; b Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Correspondence to: Prof Juan C Celed?n, Children's Hospital of Pittsburgh of UPMC, 4401 Penn Avenue, Suite 9130, Rangos Building, Pittsburgh, PA 15224, USA
? Authors contributed equally to the manuscript
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