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Emergence of recombinant Mayaro virus strains from the Amazon basin

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  • Emergence of recombinant Mayaro virus strains from the Amazon basin

    18 August 2017

    Abstract

    Mayaro virus (MAYV), causative agent of Mayaro Fever, is an arbovirus transmitted by Haemagogus mosquitoes. Despite recent attention due to the identification of several cases in South and Central America and the Caribbean, limited information on MAYV evolution and epidemiology exists and represents a barrier to prevention of further spread.

    We present a thorough spatiotemporal evolutionary study of MAYV full-genome sequences collected over the last sixty years within South America and Haiti, revealing recent recombination events and adaptation to a broad host and vector range, including
    Aedes mosquito species.

    We employed a Bayesian phylogeography approach to characterize the emergence of recombinants in Brazil and Haiti and report evidence in favor of the putative role of human mobility in facilitating recombination among MAYV strains from geographically distinct regions.

    Spatiotemporal characteristics of recombination events and the emergence of this previously neglected virus in Haiti, a known hub for pathogen spread to the Americas, warrants close monitoring of MAYV infection in the immediate future.


    we propose that recent changes in human mobility patterns connecting ..... Brazilian regions may have facilitated recombination between the two MAYV genotypes, as well as their introduction to non-endemic areas such as S?o Paulo and Haiti


    Schematic representation of the relationship between MAYV spread and human population connectivity and migration patterns among central South American and Haiti following the 2010 Haiti earthquake.

    LINK TO FULL ARTICLE
    ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

  • #2
    Rumors regarding Mayaro virus. May be some news will come up.
    ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

    Comment


    • #3
      Published Date: 2018-09-09 19:23:51
      Subject: PRO/EDR> Undiagnosed febrile illness - Haiti: Mayaro virus susp. RFI
      Archive Number: 20180909.6018117

      UNDIAGNOSED ILLNESS - HAITI: MAYARO VIRUS SUSPECTED, REQUEST FOR INFORMATION
      ************************************************** **************************

      Date: 9 Sep 2018
      Source: ProMED-mail


      [There has been significant chatter on social media from individuals working in Haiti and their colleagues, friends and family, suggesting there is a "new, as yet undiagnosed outbreak," possibly of a mosquito-borne disease, in the expat and local Haitian communities. Some of the content of this social media chatter is excerpted below [edited for clarity/readability - CopyEd.MSP]. - Mod.MPP]

      ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
      Richard Horton, Editor-in-Chief The Lancet

      ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

      Comment


      • #4
        Brazil - Mayaro, a relative of the chikungunya virus, is already circulating in the Southeast, points out UFRJ

        16 05 2019

        Researchers at the University of Rio de Janeiro (UFRJ) have discovered that the Mayaro virus, a relative of the chikungunya, is circulating in the state. The new virus causes disease with symptoms similar to those of other arboviruses such as chikungunya. Symptoms are high fever, muscle aches, headaches and joints.


        "The mayaro is already here and it is transmitted by the mosquito Haemagogus, the same mosquito that transmits the virus of the yellow fever. The Mayaro virus that is here in Rio de Janeiro, as well as that of yellow fever, is still wild, that is, it is in the high forests, it has not yet become eminently urban, "explained Rodrigo Brindeiro, one of the authors of the study on the virus mayaro and coordinator of the Zika Network of UFRJ.


        According to a recently reported study, in recent years the number of mayaro virus infections has increased in the central and northern regions of Brazil. Since the last chikungunya epidemic in 2016, researchers have already warned of the risk of the spread of the Mayaro virus in large cities in the southeast region and with potential to establish an epidemic scenario in Brazil.

        The mayaro virus is an arbovirus of the Togaviridae family, genus Alphavirus, whose main vector is the Haemagogus mosquito, which lives in more wild areas, such as forests or closed forests.


        According to Am?lcar Tanuri, coordinator of the Laboratory of Molecular Virology of UFRJ, where the study was conducted, in 2016, 279 samples had clinical indication of chikungunya. However, 57 gave inconclusive results.

        "We became suspicious and decided to take a molecular test to test inconclusive samples. To our surprise, of these 57 samples, we found three containing RNA compatible with mayaro and coincidentally the samples were from residents of the city of Niteroi and autochthonous, "he explained.


        The epidemiological history of mayaro infection began in 1954 in Trinidad and Tobago when the virus was isolated from blood samples from five rural workers who had a febrile illness. The virus was named in reference to the municipality of Mayaro, southeast of Trinidad, where cases were recorded.

        The virus has been reported in some countries of Central and South America, usually in places with tropical forests such as French Guiana, Bolivia, Peru, Suriname, Costa Rica, Guatemala, Venezuela, Mexico, Ecuador, Guyana, Panama and Brazil.
        Pesquisadores da Universidade do Rio de Janeiro (UFRJ) descobriram que o v?rus mayaro, parente do chikungunya, est? circulando no Estado. O novo v?rus causa doen?a com sintomas semelhantes ?s de infec??es por outros arbov?rus como o chikungunya. Os sintomas s?o febre alta, dores musculares, de cabe?a e nas articula??es. “O mayaro j? est? aqui e …
        ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
        Richard Horton, Editor-in-Chief The Lancet

        ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

        Comment

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