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Euro Surveill. Health professions and risk of sporadic Creutzfeldt–Jakob disease, 1965 to 2010

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  • Euro Surveill. Health professions and risk of sporadic Creutzfeldt–Jakob disease, 1965 to 2010

    [Source: Eurosurveillance, full text: (LINK). Abstract, edited.]
    Eurosurveillance, Volume 17, Issue 15, 12 April 2012

    Research articles

    Health professions and risk of sporadic Creutzfeldt–Jakob disease, 1965 to 2010

    E Alcalde-Cabero<SUP>1</SUP>, J Almazán-Isla<SUP>1</SUP>, J P Brandel<SUP>2</SUP>, M Breithaupt<SUP>3</SUP>, J Catarino<SUP>4</SUP>, S Collins<SUP>5</SUP>, J Haybäck<SUP>6</SUP>, R Höftberger<SUP>7</SUP>, E Kahana<SUP>8</SUP>, G G Kovacs<SUP>7</SUP><SUP>,9</SUP>, A Ladogana<SUP>10</SUP>, E Mitrova<SUP>11</SUP>, A Molesworth<SUP>12</SUP>, Y Nakamura<SUP>13</SUP>, M Pocchiari<SUP>10</SUP>, M Popovic<SUP>14</SUP>, M Ruiz-Tovar<SUP>1</SUP>, A L Taratuto<SUP>15</SUP>, C van Duijn<SUP>16</SUP>, M Yamada<SUP>17</SUP>, R G Will<SUP>12</SUP>, I Zerr<SUP>3</SUP>, J de Pedro Cuesta ()<SUP>1</SUP>
    1. National Centre of Epidemiology - Consortium for Biomedical Research in Neurodegenerative Diseases (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas – CIBERNED), Carlos III Institute of Health, Madrid, Spain
    2. Institut National de la Santé et de la Recherche Médicale (INSERM) UMRS 975, National CJD Surveillance Network, Assistance publique - Hôpitaux de Paris (APHP), National Reference Centre for CJD, Pitié-Salpêtrière Hospital Group, Paris, France
    3. Department of Neurology, National Reference Centre for TSE, Georg-August University, Göttingen, Germany
    4. Alameda Epidemiology and Health Statistics Department, Lisbon, Portugal
    5. Department of Pathology, University of Melbourne, Melbourne, Australia
    6. Institute of Neuropathology, Zurich University Hospital, Zurich, Switzerland
    7. Institute of Neurology, Vienna Medical University, Vienna, Austria
    8. Department of Neurology, Barzilai Medical Centre, Ashkelon, Israel
    9. National Reference Centre for Human Prion Diseases, Semmelweis University, Budapest, Hungary
    10. Department of Cell Biology and Neurosciences, Health Institute, Rome, Italy
    11. Department of Prion Diseases, Slovak Medical University Research Base, Bratislava, Slovakia
    12. National CJD Research and Surveillance Unit, Western General Hospital, Edinburgh, United Kingdom
    13. Department of Public Health, Jichi Medical University, Shimotsuke, Japan
    14. Institute of Pathology, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia
    15. Department of Neuropathology/FLENI, Referral Centre for CJD and other TSEs, Institute for Neurological Research, Buenos Aires, Argentina
    16. National Surveillance of CJD, Erasmus MC, Rotterdam, The Netherlands
    17. Neurology Department, Kanazawa University Hospital, Kanazawa, Japan
    Citation style for this article: Alcalde-Cabero E, Almazán-Isla J, Brandel JP, Breithaupt M, Catarino J, Collins S, Haybäck J, Höftberger R, Kahana E, Kovacs GG, Ladogana A, Mitrova E, Molesworth A, Nakamura Y, Pocchiari M, Popovic M, Ruiz-Tovar M, Taratuto AL, van Duijn C, Yamada M, Will RG, Zerr I, de Pedro Cuesta J. Health professions and risk of sporadic Creutzfeldt–Jakob disease, 1965 to 2010 . Euro Surveill. 2012;17(15):pii=20144. Available online:
    Date of submission: 04 November 2011
    <HR>In 2009, a pathologist with sporadic Creutzfeldt–Jakob Disease (sCJD) was reported to the Spanish registry. This case prompted a request for information on health-related occupation in sCJD cases from countries participating in the European Creutzfeldt Jakob Disease Surveillance network (EuroCJD). Responses from registries in 21 countries revealed that of 8,321 registered cases, 65 physicians or dentists, two of whom were pathologists, and another 137 healthcare workers had been identified with sCJD. Five countries reported 15 physicians and 68 other health professionals among 2,968 controls or non-cases, suggesting no relative excess of sCJD among healthcare professionals. A literature review revealed: (i) 12 case or small case-series reports of 66 health professionals with sCJD, and (ii) five analytical studies on health-related occupation and sCJD, where statistically significant findings were solely observed for persons working at physicians' offices (odds ratio: 4.6 (95 CI: 1.2–17.6)). We conclude that a wide spectrum of medical specialities and health professions are represented in sCJD cases and that the data analysed do not support any overall increased occupational risk for health professionals. Nevertheless, there may be a specific risk in some professions associated with direct contact with high human-infectivity tissue.
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