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Euro Surveill. Description and analysis of 12 years of surveillance for Creutzfeldt–Jakob disease in Denmark, 1997 to 2008

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  • Euro Surveill. Description and analysis of 12 years of surveillance for Creutzfeldt–Jakob disease in Denmark, 1997 to 2008

    [Source: Eurosurveillance, full text: (LINK). Abstract, edited.]
    Eurosurveillance, Volume 17, Issue 15, 12 April 2012

    Surveillance and outbreak reports


    Description and analysis of 12 years of surveillance for Creutzfeldt–Jakob disease in Denmark, 1997 to 2008


    S Gubbels ()<SUP>1</SUP><SUP>,2</SUP>, S Bacci<SUP>1</SUP><SUP>,2</SUP>, H Laursen<SUP>3</SUP>, H Høgenhaven<SUP>4</SUP>, S Cowan<SUP>1</SUP>, K Mølbak<SUP>1</SUP>, M Christiansen<SUP>5</SUP>
    1. Department of Epidemiology, Statens Serum Institut, Copenhagen, Denmark
    2. European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, Stockholm, Sweden
    3. Neuropathology Laboratory, Rigshospitalet, Copenhagen, Denmark
    4. Department of Clinical Neurophysiology, Rigshospitalet, Copenhagen, Denmark
    5. Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
    <HR>
    Citation style for this article: Gubbels S, Bacci S, Laursen H, Høgenhaven H, Cowan S, Mølbak K, Christiansen M. Description and analysis of 12 years of surveillance for Creutzfeldt–Jakob disease in Denmark, 1997 to 2008. Euro Surveill. 2012;17(15):pii=20142. Available online: http://www.eurosurveillance.org/View...rticleId=20142
    Date of submission: 10 May 2011
    <HR>Prospective surveillance of Creutzfeldt–Jakob disease (CJD) was initiated in Denmark in 1997, following the observation of variant CJD in the United Kingdom. Demographic, clinical and diagnostic information was collected for each patient with clinical suspicion of CJD. Here we describe the methods for surveillance and the observed outcomes between 1 January 1997 and 31 December 2008. A total of 83 patients were classified as sporadic CJD, 47 were definite diagnoses, 34 probable and two possible. This resulted in a mean incidence of 1.26 patients with probable and definite sporadic CJD per million inhabitants. Two sporadic CJD patients were found to have a genetic variant of unknown significance: Thr201Ser and Glu200Asp. One patient was diagnosed with Gerstmann-Sträussler-Scheinker syndrome. No patients were classified as having variant, iatrogenic or familial CJD. The Danish surveillance system, like those in other countries, has a multidisciplinary approach, which is labour-intensive and time-consuming but ensures the most complete set of information possible. With this approach we think that patients with variant CJD would have been detected had they occurred in Denmark. Certain aspects of CJD surveillance need further discussion at European level and beyond, in order to find a balance between efficiency of the systems and accuracy of surveillance data.
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