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Emerg Infect Dis. Transmission Routes for Nipah Virus from Malaysia and Bangladesh

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  • Emerg Infect Dis. Transmission Routes for Nipah Virus from Malaysia and Bangladesh

    [Source: Emerging Infectious Diseases Journal, full text: (LINK). Abstract, edited.]
    Research

    Transmission Routes for Nipah Virus from Malaysia and Bangladesh


    Bronwyn A. Clayton, Deborah Middleton, Jemma Bergfeld, Jessica Haining, Rachel Arkinstall, Linfa Wang, and Glenn A. Marsh

    Author affiliations: Author affiliations: Commonwealth Scientific and Industrial Research Organisation Livestock Industries, Geelong, Victoria, Australia (B.A. Clayton, D. Middleton, J. Bergfeld, J. Haining, R. Arkinstall, L. Wang, G.A. Marsh); University of Melbourne, Parkville, Victoria, Australia (B.A. Clayton); Duke?National University of Singapore Graduate Medical School, Singapore (L. Wang)



    Abstract


    Human infections with Nipah virus in Malaysia and Bangladesh are associated with markedly different patterns of transmission and pathogenicity. To compare the 2 strains, we conducted an in vivo study in which 2 groups of ferrets were oronasally exposed to either the Malaysia or Bangladesh strain of Nipah virus. Viral shedding and tissue tropism were compared between the 2 groups. Over the course of infection, significantly higher levels of viral RNA were recovered from oral secretions of ferrets infected with the Bangladesh strain. Higher levels of oral shedding of the Bangladesh strain of Nipah virus might be a key factor in onward transmission in outbreaks among humans.
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