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Research news: New compound blocks 'gatekeeper' enzyme to kill malaria

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  • Research news: New compound blocks 'gatekeeper' enzyme to kill malaria
    ScienceDaily: Your source for the latest research news
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    New compound blocks 'gatekeeper' enzyme to kill malaria
    July 1, 2014
    Walter and Eliza Hall Institute
    Researchers are homing in on a new target for malaria treatment, after developing a compound that blocks the action of a key 'gatekeeper' enzyme essential for malaria parasite survival. The compound, called WEHI-916, is the first step toward a new class of antimalarial drugs that could cure and prevent malaria infections caused by all species of the parasite, including those resistant to existing drugs.
    Journal Reference:

    Brad E. Sleebs, Sash Lopaticki, Danushka S. Marapana, Matthew T. O'Neill, Pravin Rajasekaran, Michelle Gazdik, Svenja G?nther, Lachlan W. Whitehead, Kym N. Lowes, Lea Barfod, Lars Hviid, Philip J. Shaw, Anthony N. Hodder, Brian J. Smith, Alan F. Cowman, Justin A. Boddey. Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites. PLoS Biology, 2014; 12 (7): e1001897 DOI: 10.1371/journal.pbio.1001897

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