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The Lancet. Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
[Source: The Lancet, full text: (LINK). Abstract, edited.]
[Review] Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa
Nicholas A Feasey, Gordon Dougan, Robert A Kingsley, Robert S Heyderman, Melita A Gordon
Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of bloodstream infection in African adults and children, with an associated case fatality of 20?25%. The clinical presentation of invasive non-typhoidal salmonella disease in Africa is diverse: fever, hepatosplenomegaly, and respiratory symptoms are common, and features of enterocolitis are often absent. The most important risk factors are HIV infection in adults, and malaria, HIV, and malnutrition in children. A distinct genotype of Salmonella enterica var Typhimurium, ST313, has emerged as a new pathogenic clade in sub-Saharan Africa, and might have adapted to cause invasive disease in human beings.
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Nicholas A Feasey, Gordon Dougan, Robert A Kingsley, Robert S Heyderman, Melita A Gordon
Invasive strains of non-typhoidal salmonellae have emerged as a prominent cause of bloodstream infection in African adults and children, with an associated case fatality of 20?25%. The clinical presentation of invasive non-typhoidal salmonella disease in Africa is diverse: fever, hepatosplenomegaly, and respiratory symptoms are common, and features of enterocolitis are often absent. The most important risk factors are HIV infection in adults, and malaria, HIV, and malnutrition in children. A distinct genotype of Salmonella enterica var Typhimurium, ST313, has emerged as a new pathogenic clade in sub-Saharan Africa, and might have adapted to cause invasive disease in human beings.