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http://www.ajol.info/index.php/jmbr/article/view/81350
From conclusion:
Melamine: An Emerging Neurotoxicant?
K Ibhazehiebo, N Koibuchi
Abstract
Melamine is an organic compound used in combination with formaldehyde in the manufacture of plastics and also used as a flame retardant especially in buses and aircrafts. In the summer of 2008, multiple illness and deaths of children in China was associated with melamine tainted powdered infant milk. Ever since, there has been serious public health concern over the toxic potentials of melamine especially amongst growing infants. We therefore set to investigate the neurotoxicity of melamine using transient transfection-based reporter gene assay and found that low dose melamine suppressed thyroid hormone receptor (TR)-mediated gene expression at 1uM. We further examined the effect of melamine on TR-thyroid hormone response (TRE) binding and found no dissociation of TR from TRE. Melamine did not also suppress co-activator (Steroid receptor co-activator 1; SRC-1) binding with TR, neither did it recruit co-repressors (nuclear co-repressor; N-CoR) to TR in the presence of thyroid hormone. Taken together, our data shows that melamine can interfere with TR-mediated gene expression and consequently may be inimical to the developing brain.
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Journal of Medicine and Biomedical Research. ISSN: 1596-6941
K Ibhazehiebo, N Koibuchi
Abstract
Melamine is an organic compound used in combination with formaldehyde in the manufacture of plastics and also used as a flame retardant especially in buses and aircrafts. In the summer of 2008, multiple illness and deaths of children in China was associated with melamine tainted powdered infant milk. Ever since, there has been serious public health concern over the toxic potentials of melamine especially amongst growing infants. We therefore set to investigate the neurotoxicity of melamine using transient transfection-based reporter gene assay and found that low dose melamine suppressed thyroid hormone receptor (TR)-mediated gene expression at 1uM. We further examined the effect of melamine on TR-thyroid hormone response (TRE) binding and found no dissociation of TR from TRE. Melamine did not also suppress co-activator (Steroid receptor co-activator 1; SRC-1) binding with TR, neither did it recruit co-repressors (nuclear co-repressor; N-CoR) to TR in the presence of thyroid hormone. Taken together, our data shows that melamine can interfere with TR-mediated gene expression and consequently may be inimical to the developing brain.
Full Text:
EMAIL FREE FULL TEXT
DOWNLOAD FULL TEXT
Journal of Medicine and Biomedical Research. ISSN: 1596-6941
From conclusion:
...Given the widespread
contamination of consumer products by
melamine especially infant milk formula
and the specter of abnormalities that could
arise from disruption of TH homeostasis
especially on the developing brain, there is
urgent need to carefully monitor consumer
products to make sure they are melamine free.
contamination of consumer products by
melamine especially infant milk formula
and the specter of abnormalities that could
arise from disruption of TH homeostasis
especially on the developing brain, there is
urgent need to carefully monitor consumer
products to make sure they are melamine free.