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This article has a delayed release (embargo) and will be available in PMC on June 1, 2020. (So don't know if the timing of the cases is temporally related to the new coronavirus.)
Iran J Child Neurol. 2020 Spring;14(2):87-92.
Three Cases of Acute Necrotizing Encephalopathy: Is It an Epidemic or Only Incidental?
Ahmadabadi F1, Ruhollahi S2, Maskani R1, Jafari N3, Karimi Dardashti S4.
Author information
Abstract
Acute necrotizing encephalopathy of childhood (ANEC) is a disease, characterized by a respiratory or gastrointestinal infection, accompanied with fever, rapid alteration of consciousness, and seizures. The clinical characteristics of ANEC include acute encephalopathy following a viral infection, seizure, altered consciousness, and absence of cerebrospinal fluid (CSF) pleocytosis, with an occasional increase in the level of proteins. This disease is almost exclusively seen in previously healthy infants and children from East Asia. Serial magnetic resonance imaging (MRI) examinations have demonstrated symmetric lesions involving the thalami, brainstem, cerebellum, and white matter. ANEC has a poor prognosis with high morbidity and mortality rates. Herein, we present three cases of ANEC, who were referred to Bu-Ali Hospital of Ardabil, Iran during two weeks. Report of these three cases promoted the idea of an epidemic. The purpose of this case series was to raise the issue that ANEC may occur as an epidemic.
KEYWORDS:
Acute necrotizing encephalopathy (ANE); Pediatric; Seizure
PMID:32256627PMCID:PMC7085126[Available on 2020-06-01]
Three Cases of Acute Necrotizing Encephalopathy: Is It an Epidemic or Only Incidental?
Ahmadabadi F1, Ruhollahi S2, Maskani R1, Jafari N3, Karimi Dardashti S4.
Author information
Abstract
Acute necrotizing encephalopathy of childhood (ANEC) is a disease, characterized by a respiratory or gastrointestinal infection, accompanied with fever, rapid alteration of consciousness, and seizures. The clinical characteristics of ANEC include acute encephalopathy following a viral infection, seizure, altered consciousness, and absence of cerebrospinal fluid (CSF) pleocytosis, with an occasional increase in the level of proteins. This disease is almost exclusively seen in previously healthy infants and children from East Asia. Serial magnetic resonance imaging (MRI) examinations have demonstrated symmetric lesions involving the thalami, brainstem, cerebellum, and white matter. ANEC has a poor prognosis with high morbidity and mortality rates. Herein, we present three cases of ANEC, who were referred to Bu-Ali Hospital of Ardabil, Iran during two weeks. Report of these three cases promoted the idea of an epidemic. The purpose of this case series was to raise the issue that ANEC may occur as an epidemic.
KEYWORDS:
Acute necrotizing encephalopathy (ANE); Pediatric; Seizure
PMID:32256627PMCID:PMC7085126[Available on 2020-06-01]