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Novel cyclovirus - Multistate - central nervous system infections (ECDC/CDTR, July 16 2013, extracts)
[Source: European Centre for Disease Prevention and Control (ECDC), full PDF document: (LINK). Extracts.]
COMMUNICABLE DISEASE THREATS REPORT
Week 28, 7-13 July 2013
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Novel cyclovirus - Multistate - central nervous system infections
Opening date: 19 June 2013
Epidemiological summary
An article published in mBio on 18 June 2013 described the identification of a novel cyclovirus, named CyCV-VN, in CSF specimens from two Vietnamese patients with CNS infections of unknown aetiology.
Subsequently CyCV-VN was detected in 26 of 642 (4%) acute-infection CSF specimens (collected from 1999 to 2009), including 10 of 273 (3.7%) CSF specimens from patients with CNS infections of unknown aetiology and 16 of 369 (4.3%) samples from patients in whom laboratory-confirmed CNS infection with other pathogens was established. CyCV-VN DNA was also detected in 8 of 188 (4.2%) faecal specimens from healthy children.
When specimens from poultry and pigs were tested, the virus was detected in 38 of the 65 specimens (58%).
Another article published online on 10 June 2013 in Emerging Infectious Diseases described the detection of cyclovirus in eight (15%) of 54 serum samples and 4 (10%) of 40 CSF samples from paraplegia patients in Malawi.
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ECDC assessment
This is the first time that cyclovirus has been associated with human infection. At this point, epidemiological data on cyclovirus infections and carriage in humans are very limited. Consequently, the risk for disease occurrence in humans cannot be assessed with any degree of accuracy until further studies are carried out.
Actions
ECDC published a rapid risk assessment on 8 July 2013.
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COMMUNICABLE DISEASE THREATS REPORT
Week 28, 7-13 July 2013
(?)
Novel cyclovirus - Multistate - central nervous system infections
Opening date: 19 June 2013
Epidemiological summary
An article published in mBio on 18 June 2013 described the identification of a novel cyclovirus, named CyCV-VN, in CSF specimens from two Vietnamese patients with CNS infections of unknown aetiology.
Subsequently CyCV-VN was detected in 26 of 642 (4%) acute-infection CSF specimens (collected from 1999 to 2009), including 10 of 273 (3.7%) CSF specimens from patients with CNS infections of unknown aetiology and 16 of 369 (4.3%) samples from patients in whom laboratory-confirmed CNS infection with other pathogens was established. CyCV-VN DNA was also detected in 8 of 188 (4.2%) faecal specimens from healthy children.
When specimens from poultry and pigs were tested, the virus was detected in 38 of the 65 specimens (58%).
Another article published online on 10 June 2013 in Emerging Infectious Diseases described the detection of cyclovirus in eight (15%) of 54 serum samples and 4 (10%) of 40 CSF samples from paraplegia patients in Malawi.
(?)
ECDC assessment
This is the first time that cyclovirus has been associated with human infection. At this point, epidemiological data on cyclovirus infections and carriage in humans are very limited. Consequently, the risk for disease occurrence in humans cannot be assessed with any degree of accuracy until further studies are carried out.
Actions
ECDC published a rapid risk assessment on 8 July 2013.
(?)
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