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Emerg Infect Dis. Postexposure Treatment of Marburg Virus Infection

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  • Emerg Infect Dis. Postexposure Treatment of Marburg Virus Infection

    [Source: Emerging Infectious Diseases Journal, full PDF Document (LINK). Abstract, edited.]

    DOI: 10.3201/eid1607.100159

    Suggested citation for this article: Geisbert TW, Hensley LE, Geisbert JB, Leung A, Johnson JC, Grolla A, et al. Postexposure treatment of Marburg virus infection. Emerg Infect Dis. 2010 Jul; [Epub ahead of print]

    Postexposure Treatment of Marburg Virus Infection

    Thomas W. Geisbert, Lisa E. Hensley, Joan B. Geisbert, Anders Leung, Joshua C. Johnson, Allen Grolla, and Heinz Feldmann

    Author affiliations: National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA (T.W. Geisbert, J.B. Geisbert); US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA (L.E. Hensley, J.C. Johnson); Public Health Agency of Canada, Winnipeg, Manitoba, Canada (A. Leung, A. Grolla); and National Institutes of Health, Hamilton, Montana, USA (H. Feldmann)

    Rhesus monkeys are protected from disease when a recombinant vesicular stomatitis virus?based vaccine is administered 20?30 min after infection with Marburg virus. We protected 5/6 monkeys when this vaccine was given 24 h after challenge; 2/6 animals were protected when the vaccine was administered 48 h postinfection.