Cholera vaccine study in Haiti suggests problems with current booster regimen

June 16, 2016
Cholera outbreaks are on the rise. To prevent and control them, three oral cholera vaccines are currently approved by WHO. A study examining the immune response to one of them in Haitian adults finds that while the first vaccine round elicits a strong cholera-specific response in the mucosa (the first point of contact with the cholera pathogen), the booster dose after 2 weeks does not appear to stimulate the immune system further...

Journal Reference:

Wilfredo R. Matias, Brie Falkard, Richelle C. Charles, Leslie M. Mayo-Smith, Jessica E. Teng, Peng Xu, Pavol Kováč, Edward T. Ryan, Firdausi Qadri, Molly F. Franke, Louise C. Ivers, Jason B. Harris. Antibody Secreting Cell Responses following Vaccination with Bivalent Oral Cholera Vaccine among Haitian Adults. PLOS Neglected Tropical Diseases, 2016; 10 (6): e0004753 DOI: 10.1371/journal.pntd.0004753