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Source: http://7thspace.com/headlines/462654...treatment.html
Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, remains an important public health issue in many Central and South American countries, as well as non-endemic areas with high rates of immigration from these countries. Existing treatment options for CD are limited and often unsatisfactory.
Moreover the lack of post-treatment tests of cure limits the development of new drugs. To address this issue, we sought to identify serum biomarkers following nifurtimox (Nfx) treatment that could be used as an early test of cure and/or markers of a therapeutic response...
...Conclusions: The normalization of biomarker patterns strongly associated with CD suggests that these markers can be used to identify patients in whom Nfx treatment is successful. We believe that these are the first biomarkers predictive of cure in CD patients.
Author: Cynthia SantamariaEric ChatelainYves JacksonQianqian MiaoBrian J WardFrançois ChappuisMomar Ndao
Credits/Source: BMC Infectious Diseases 2014, 14:302
Published on: 2014-06-03
Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, remains an important public health issue in many Central and South American countries, as well as non-endemic areas with high rates of immigration from these countries. Existing treatment options for CD are limited and often unsatisfactory.
Moreover the lack of post-treatment tests of cure limits the development of new drugs. To address this issue, we sought to identify serum biomarkers following nifurtimox (Nfx) treatment that could be used as an early test of cure and/or markers of a therapeutic response...
...Conclusions: The normalization of biomarker patterns strongly associated with CD suggests that these markers can be used to identify patients in whom Nfx treatment is successful. We believe that these are the first biomarkers predictive of cure in CD patients.
Author: Cynthia SantamariaEric ChatelainYves JacksonQianqian MiaoBrian J WardFrançois ChappuisMomar Ndao
Credits/Source: BMC Infectious Diseases 2014, 14:302
Published on: 2014-06-03