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Virus in cattle linked to human breast cancer

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  • Virus in cattle linked to human breast cancer

    A new study by UC Berkeley researchers establishes for the first time a link between infection with the bovine leukemia virus and human breast cancer. UC Berkeley researchers have linked bovine leukemia virus, a cancer-causing virus prevalent in ...

    Virus in cattle linked to human breast cancer

    By Sarah Yang | September 15, 2015
    A new study by UC Berkeley researchers establishes for the first time a link between infection with the bovine leukemia virus and human breast cancer.
    ...
    ?The association between BLV infection and breast cancer was surprising to many previous reviewers of the study, but it?s important to note that our results do not prove that the virus causes cancer,? said study lead author Gertrude Buehring, a professor of virology in the Division of Infectious Diseases and Vaccinology at UC Berkeley?s School of Public Health. ?However, this is the most important first step. We still need to confirm that the infection with the virus happened before, not after, breast cancer developed, and if so, how.?...
    Study referenced:
    Background Age, reproductive history, hormones, genetics, and lifestyle are known risk factors for breast cancer, but the agents that initiate cellular changes from normal to malignant are not understood. We previously detected bovine leukemia virus (BLV), a common oncogenic virus of cattle, in the breast epithelium of humans. The objective of this study was to determine whether the presence of BLV DNA in human mammary epithelium is associated with breast cancer. Methods This was a case-control study of archival formalin fixed paraffin embedded breast tissues from 239 donors, received 2002–2008 from the Cooperative Human Tissue Network. Case definition as breast cancer versus normal (women with no history of breast cancer) was established through medical records and examination of tissues by an anatomical pathologist. Breast exposure to BLV was determined by in situ-PCR detection of a biomarker, BLV DNA, localized within mammary epithelium. Results The frequency of BLV DNA in mammary epithelium from women with breast cancer (59%) was significantly higher than in normal controls (29%) (multiply- adjusted odds ratio = 3.07, confidence interval = 1.66–5.69, p = .0004, attributable risk = 37%). In women with premalignant breast changes the frequency of BLV DNA was intermediate (38%) between that of women with breast cancer and normal controls (p for trend < .001). Conclusions Among the specimens in this study, the presence of amplified BLV DNA was significantly associated with breast cancer. The odds ratio magnitude was comparable to those of well-established breast cancer risk factors related to reproductive history, hormones, and lifestyle and was exceeded only by risk factors related to genetics (familial breast cancer), high dose ionizing radiation, and age. These findings have the potential for primary and secondary prevention of breast cancer.


    Learn about the veterinary topic of Bovine Leukosis. Find specific details on this topic and related topics from the Merck Vet Manual.

    ...Enzootic bovine leukosis is caused by BLV, an exogenous C-type oncogenic retrovirus of the BLV-human T-lymphotropic virus group.
    ...The prevalence of BLV infection varies from country to country. Many European countries, Australia, and New Zealand have eradication programs in place that have led to negligible rates of BLV infection. Although voluntary control programs are in place in the USA, prevalence is high compared with much of the rest of the world. The most recent surveys in the USA estimate that 44% of dairy and 10% of beef cattle are infected with the virus. Prevalence tends to increase on dairies with increasing herd size, while the converse is true in beef cattle. In general, the prevalence of viral infection increases with age.
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