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Cancer is becoming the most important public health burden around the globe - NE India region is seeing a marked increase in cancer incidence and deaths

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  • Cancer is becoming the most important public health burden around the globe - NE India region is seeing a marked increase in cancer incidence and deaths

    Cancer: Scenario and Relationship of Different Geographical
    Areas of the Globe with Special Reference to North East-India
    Jagannath Dev Sharma1, Manoj Kalit1*, Tulika Nirmolia2, Sidhartha Protim
    Saikia2, Arpita Sharma1, Debanjana Barman1
    Abstract
    Background: Cancer is becoming the most important public health burden around the globe. As per the
    GLOBOCAN 2008 estimates, about 12.7 million cancer cases and 7.6 million cancer deaths were estimated
    to have occurred in 2008. The burden of cancer cases for India in the year 2020 is calculated to be 1,148,757
    (male 534,353; female 614,404) compared to 979,786 in 2010. The pattern of cancer incidence is varying among
    geographical regions, esophageal cancer for example being high in China, lung cancer in USA, and gallbladder
    cancer in Chile. The question remains why? Is it due to the diversity in genome pool, food habits, risk factor
    association and role of genetic susceptibility or some other factors associated with it? In India, the North East
    (NE)-India region is seeing a marked increase in cancer incidence and deaths, with a very different cancer
    incidence pattern compared to mainland India. The genome pool of the region is also quite distinct from the rest
    of India. Northeastern tribes are quite distinct from other groups; they are more closely related to East Asians
    than to other Indians. In this paper an attempt was made to see whether there is any similarity among the pattern
    of cancer incidence cases for different sites of NE-India region to South or East-Asia. Materials and Methods:
    Principal Component Analysis (PCA), Hierarchical Cluster Analysis (HCA), Pearson Correlation coefficient test
    was assessed to evaluate the linkage of North-East India region to other regions. A p value <0.05 was considered
    as statistically significant. Results: The results clearly shows that there are similarities in occurrence of cancer
    incidence patterns for various cancer sites of NE-India with South and East-Asian regions, which may lead to
    the conclusion that there might be a genetic linkage between these regions.
    Keywords: Cancer - oesophagus - lung - stomach - hypopharynx - nasopharynx - TRC
    Asian Pac J Cancer Prev, 15 (8), 3721-3729
    “‘i love myself.’ the quietest. simplest. most powerful. revolution ever.” ---- nayyirah waheed

    Avatar: Franz Marc, Liegender Hund im Schnee 1911 (My posts are not intended as advice or professional assessments of any kind.)
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