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  • Positive results in myeloma study

    Source: http://calgary.ctvnews.ca/positive-r...study-1.935371

    Positive results in myeloma study
    ctvcalgary
    Published Wednesday, Aug. 29, 2012 3:50PM MDT
    Last Updated Wednesday, Aug. 29, 2012 5:33PM MDT

    A group of Calgary-based researchers have uncovered a possible treatment for multiple myeloma.

    Researchers at the University of Calgary and Tom Baker Cancer Centre have finished a multi-year study in which scientists injected the common reovirus into animals with multiple myeloma.

    The study found the virus killed the cancer cells without damaging normal, healthy cells.

    This year, there have been 2,400 new cases of multiple myeloma in Canada

    Scientists are excited to see where the study will lead research in the future...

  • #2
    Re: Positive results in myeloma study

    http://www.ncbi.nlm.nih.gov/pubmed/22761466
    Clin Cancer Res. 2012 Aug 3. [Epub ahead of print]
    Reovirus as a Viable Therapeutic Option for the Treatment of Multiple Myeloma.
    Thirukkumaran CM, Shi ZQ, Luider J, Kopciuk K, Gao H, Bahlis N, Neri P, Pho M, Stewart D, Mansoor A, Morris DG.
    Source

    Authors' Affiliations: Department of Oncology, University of Calgary; Tom Baker Cancer Center; Calgary Laboratory Services, Calgary; and Department of Public Health Sciences, School of Public Health, University of Alberta, Alberta, Canada.
    Abstract
    PURPOSE:

    Despite the recent advances made in the treatment of multiple myeloma, the disease still remains incurable. The oncolytic potential of reovirus has previously been shown and is currently in phase III clinical trials for solid tumors. We tested the hypothesis that reovirus can successfully target human multiple myeloma in vitro, ex vivo, and in vivo without affecting human hematopoietic stem cell (HHSC) re-population/differentiation in a murine model that partially recapitulates human multiple myeloma.
    [snip]
    CONCLUSIONS:

    The unique ability of reovirus to selectively kill multiple myeloma while sparing HHSCs places it as a promising systemic multiple myeloma therapeutic for clinical testing. Clin Cancer Res; 1-11. ?2012 AACR.
    _____________________________________________

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