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Sci Reports. Transmission of Ebola virus from pigs to non-human primates

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  • Sci Reports. Transmission of Ebola virus from pigs to non-human primates

    Source: Scientific reports. 2012 2:811

    Transmission of Ebola virus from pigs to non-human primates.

    Weingartl, Hana M; Embury-Hyatt, Carissa; Nfon, Charles; Leung, Anders; Smith, Greg; Kobinger, Gary

    PMID: 23155478

    DOI: 10.1038/srep00811


    Abstract

    Ebola viruses (EBOV) cause often fatal hemorrhagic fever in several species of simian primates including human. While fruit bats are considered natural reservoir, involvement of other species in EBOV transmission is unclear. In 2009, Reston-EBOV was the first EBOV detected in swine with indicated transmission to humans. In-contact transmission of Zaire-EBOV (ZEBOV) between pigs was demonstrated experimentally. Here we show ZEBOV transmission from pigs to cynomolgus macaques without direct contact. Interestingly, transmission between macaques in similar housing conditions was never observed. Piglets inoculated oro-nasally with ZEBOV were transferred to the room housing macaques in an open inaccessible cage system. All macaques became infected. Infectious virus was detected in oro-nasal swabs of piglets, and in blood, swabs, and tissues of macaques. This is the first report of experimental interspecies virus transmission, with the macaques also used as a human surrogate. Our finding may influence prevention and control measures during EBOV outbreaks.


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    http://www.ncbi.nlm.nih.gov/pubmed/23155478
    Last edited by sharon sanders; April 9th, 2014, 06:48 PM. Reason: added link
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