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70-year-old malaria drug may boost cancer treatment
Indo Asian News Service
IANS India Private Limited7 November 2017 New York, Nov 7 (IANS) Scientists have found that a 70-year-old malaria drug can block immune cells in the liver so nanoparticles can arrive at their intended tumour site, overcoming a significant hurdle of targeted drug delivery.
Many cancer patients do not respond to chemotherapy because the drugs never reach the cancer cells.
Even in nanomedicine, only about one per cent of a dose of nanoparticles will successfully arrive at the intended tumour site, while the rest are filtered out by the immune cells of the liver and spleen.
However, using the drug chloroquine not only increased the circulation of nanoparticles in the body, but also reduced the body's filtration of nanoparticles, as well as improved drug delivery to breast tumours, the researchers said....
Indo Asian News Service
IANS India Private Limited7 November 2017 New York, Nov 7 (IANS) Scientists have found that a 70-year-old malaria drug can block immune cells in the liver so nanoparticles can arrive at their intended tumour site, overcoming a significant hurdle of targeted drug delivery.
Many cancer patients do not respond to chemotherapy because the drugs never reach the cancer cells.
Even in nanomedicine, only about one per cent of a dose of nanoparticles will successfully arrive at the intended tumour site, while the rest are filtered out by the immune cells of the liver and spleen.
However, using the drug chloroquine not only increased the circulation of nanoparticles in the body, but also reduced the body's filtration of nanoparticles, as well as improved drug delivery to breast tumours, the researchers said....