Originally posted by JJackson
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Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by English Teacher View PostI know that this isn't a discussion board, so I'd like to ask Dr. Niman if he will start a thread over there to explain this to the laymen like me. It seems very important, but I don't understand anything except that the H1N1 has developed a resistance to Tamiflu? Thanks.
The H274Y jumped from genetic background to genetic background, eliminating reassortment, but "random errors" made no sense because there was no involvement of Tamiflu, and Tamiflu causes other resisatnce changes in H1N1 and H3N2, but all resistance was linked H274Y in H1N1. Moreover, the emergence of H274Y in the Brisbane strain (clade 2B) was linked to additional acquistions, and the key acquistions were in clade 2C (Hong Kong strain) which was co-circulating.
The acquistions in seasonal flu were detailed here
and were due to genetic hitchhiking and recombination - and the gateway from H274Y in H5N1 and H274Y in H1N1 was the Indiana seasonal flu sequence, which was the same gateway used to move H274Y from seasonal H1N1 to pandemic (swine) H1N1.
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by niman View PostThere is no evidence that the recombination happened in San Francisco. Pandemic H1N1 with H274Y is FIT and circulating below the radar (in MILD cases).
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by English Teacher View PostI know that this isn't a discussion board, so I'd like to ask Dr. Niman if he will start a thread over there to explain this to the laymen like me. It seems very important, but I don't understand anything except that the H1N1 has developed a resistance to Tamiflu? Thanks.
Leave a comment:
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by English Teacher View PostI know that this isn't a discussion board, so I'd like to ask Dr. Niman if he will start a thread over there to explain this to the laymen like me. It seems very important, but I don't understand anything except that the H1N1 has developed a resistance to Tamiflu? Thanks.
Leave a comment:
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
I know that this isn't a discussion board, so I'd like to ask Dr. Niman if he will start a thread over there to explain this to the laymen like me. It seems very important, but I don't understand anything except that the H1N1 has developed a resistance to Tamiflu? Thanks.
Leave a comment:
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by pjie2 View PostHmmm. Is it a recombinant? If it's a recombinant, what did it recombine with in order to acquire H274Y? If there aren't any flanking polymorphisms that are derived from a different strain, how can you tell the difference between recombination and de novo mutation?
The ability of H274Y to jump from clade to clade, as well as multiple sub-clades in 2B, as well as the rapid evolution of the 2B sub-clades, raises concerns of another vaccine mismatch, as well as the associated increase in H274Y in the H1N1 gene pool. Moreover, the match between H5N1 and the recent H1N1 isolate from Indiana raises concerns that oseltamivir resistance would develop quickly after H5N1 transmission efficiencies in humans increase, regardless of oseltamivir usage.
The rapid spread of H274Y in seasonal flu and the recent reports of increases to 100% continue to be cause for concern in seasonal and pandemic flu evolution and spread.
<a rel="nofollow" href="http://www.recombinomics.com/News/09030801/H274Y_Spread.html">Commentary</a>
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by pjie2 View PostHmmm. Is it a recombinant? If it's a recombinant, what did it recombine with in order to acquire H274Y? If there aren't any flanking polymorphisms that are derived from a different strain, how can you tell the difference between recombination and de novo mutation?
<a rel="nofollow" href="http://www.recombinomics.com/News/09030801/H274Y_Spread.html">Commentary</a>
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by AlaskaDenise View PostDid anyone in her family, or any traveling HK acquaintances, have a lingering seasonal H1N1 from HK - thereby setting the stage for a dual infection?
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by JJackson View PostThanks. Sorry did not read closely enough just looked at the sequences. You were just giving Jersey Girl as a close pre change relative.
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by pjie2 View PostHmmm. Is it a recombinant? If it's a recombinant, what did it recombine with in order to acquire H274Y? If there aren't any flanking polymorphisms that are derived from a different strain, how can you tell the difference between recombination and de novo mutation?
gb|EU567011.1| Influenza A virus (A/Indiana/01/2008(H1N1)) se... 36.2 0.73
gb|DQ493078.1| Influenza A virus (A/Vietnam/CL2009/2005(H5N1)... 36.2 0.73
gb|DQ250165.1| Influenza A virus (A/Vietnam/CL2009/2005(H5N1)... 36.2 0.73
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Thanks. Sorry did not read closely enough just looked at the sequences. You were just giving Jersey Girl as a close pre change relative.
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by pjie2 View PostHmmm. Is it a recombinant? If it's a recombinant, what did it recombine with in order to acquire H274Y? If there aren't any flanking polymorphisms that are derived from a different strain, how can you tell the difference between recombination and de novo mutation?
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Originally posted by JJackson View PostIf it is YHY rather than YYY what is conferring the resistance?
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Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)
Did anyone in her family, or any traveling HK acquaintances, have a lingering seasonal H1N1 from HK - thereby setting the stage for a dual infection?
.
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