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Chest. Emergence of community-acquired Adenovirus Type 55 as a cause of community-onset pneumonia
[Source: Chest, full page: (LINK). Abstract, edited.]
Original Research | September 26, 2013
Emergence of community-acquired Adenovirus Type 55 as a cause of community-onset pneumonia
Bin Cao; Guo-Hong Huang; Zeng-Hui Pu; Jiu-Xin Qu; Xiao-Min Yu; Zhen Zhu; Jian-Ping Dong; Yan Gao; Yong-Xiang Zhang; Xiao-Hui Li; Jian-Hua Liu; Hong Wang; Qian Xu; Hui Li; Wenbo Xu; Chen Wang
Author and Funding Information: Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing (Cao, Qu, Yu, Li, Wang); National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing (Huang, Zhu, Xu); YanTai Yu Huang-Ding Hospital, Yan Tai, Shan Dong Province (Pu); Beijing Hai-Dian Hospital, Beijing (Dong); Peking University People?s Hospital, Beijing (Gao); Beijing Da-Xing Hospital, Beijing (Zhang); Lu-He Hospital of the Capital Medical University, Beijing (Li); Huai Rou Hospital, Beijing (Liu); Beijing Friendship Hospital, Capital Medical University, Beijing (Wang); China-Japan Friendship Hospital, Ministry of Health, Beijing (Xu); Institute of Respiratory Medicine, Beijing Hospital, Ministry of Heath, P.R.China; Department of Respiratory Medicine, Capital Medical University; Beijing Institute of Respiratory Medicine; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing (Wang); Xinjiang Medical University, Urumqi (Huang).
Correspondence to: Dr. Chen Wang in Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University and Beijing Hospital, Ministry of Health, cyh-birm@263.com.
Drs. Bin Cao, Guo-Hong Huang and Zeng-Hui Pu contributed equally to the paper.
Funding: This work was supported by a grant from the Beijing Science and Technology Project [grant number D101100049810002], grant from National Natural Science Foundation of China [grant number 81070005/H0104, 81030032/H19 and 81271840], China?s Key Technologies Research and Development Program of the National Ministry of Science [grant number 2013ZX10004-202 2012ZX10004201-003] Program for New Century Excellent Talents in University [grant number NCET-09-0006]
Chest. 2013. doi:10.1378/chest.13-1186 - Published online
Abstract
Background
From 2008, sporadic cases of severe cases caused by emerging Human Adenovirus Type 55 (HAdV-55) were reported in China. But no comparative studies have been conducted to discern the differences in epidemiological and clinical abnormalities between HAdV-55 and other types (HAdV-7, 3, 14, 50 and C).
Methods
A multi-center surveillance study for adult and adolescent community-acquired pneumonia was conducted prospectively in Beijing and Yan Tai between November 2010 and April 2012. A standardized data form was used to record clinical information. The viral DNA extracted from the clinical samples or adenovirus viral isolates were sequenced.
Results:
Among 969 cases, 48 (5%) were identified as adenovirus pneumonia. Six branches were clustered: HAdV-55 in 21; HAdV-7 in 11; HAdV-3 in 9; HAdV-14 in 4; HAdV-50 in 2 and HAdV-C in 1. Most HAdV-55 was identified during February and March. All the hypervariable region of the hexon genes of the 21 HAdV-55 strains was completely identical. Compared with other types (HAdV-7, 3, 14, 50 and C), patients due to HAdV-55 were about 10 years older (p=0.027) and had higher PSI score (p=0.030). Systemic blood pressure was also higher among patients in HAdV-55 group (p=0.006). Unilateral or bilateral consolidations were the most common radiological findings in both HAdV-55 group and other types (57.9% vs 36%). More than half of the patients were admitted to hospitals, oxygen therapy was given to 29.2% of the patients and two of them needed mechanical ventilation.
Conclusions
HAdV-55 has established itself as a major pneumonia pathogen among Chinese population and further surveillance and monitoring of this agent as a cause of CAP is warranted.
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Original Research | September 26, 2013
Emergence of community-acquired Adenovirus Type 55 as a cause of community-onset pneumonia
Bin Cao; Guo-Hong Huang; Zeng-Hui Pu; Jiu-Xin Qu; Xiao-Min Yu; Zhen Zhu; Jian-Ping Dong; Yan Gao; Yong-Xiang Zhang; Xiao-Hui Li; Jian-Hua Liu; Hong Wang; Qian Xu; Hui Li; Wenbo Xu; Chen Wang
Author and Funding Information: Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing (Cao, Qu, Yu, Li, Wang); National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing (Huang, Zhu, Xu); YanTai Yu Huang-Ding Hospital, Yan Tai, Shan Dong Province (Pu); Beijing Hai-Dian Hospital, Beijing (Dong); Peking University People?s Hospital, Beijing (Gao); Beijing Da-Xing Hospital, Beijing (Zhang); Lu-He Hospital of the Capital Medical University, Beijing (Li); Huai Rou Hospital, Beijing (Liu); Beijing Friendship Hospital, Capital Medical University, Beijing (Wang); China-Japan Friendship Hospital, Ministry of Health, Beijing (Xu); Institute of Respiratory Medicine, Beijing Hospital, Ministry of Heath, P.R.China; Department of Respiratory Medicine, Capital Medical University; Beijing Institute of Respiratory Medicine; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing (Wang); Xinjiang Medical University, Urumqi (Huang).
Correspondence to: Dr. Chen Wang in Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University and Beijing Hospital, Ministry of Health, cyh-birm@263.com.
Drs. Bin Cao, Guo-Hong Huang and Zeng-Hui Pu contributed equally to the paper.
Funding: This work was supported by a grant from the Beijing Science and Technology Project [grant number D101100049810002], grant from National Natural Science Foundation of China [grant number 81070005/H0104, 81030032/H19 and 81271840], China?s Key Technologies Research and Development Program of the National Ministry of Science [grant number 2013ZX10004-202 2012ZX10004201-003] Program for New Century Excellent Talents in University [grant number NCET-09-0006]
Chest. 2013. doi:10.1378/chest.13-1186 - Published online
Abstract
Background
From 2008, sporadic cases of severe cases caused by emerging Human Adenovirus Type 55 (HAdV-55) were reported in China. But no comparative studies have been conducted to discern the differences in epidemiological and clinical abnormalities between HAdV-55 and other types (HAdV-7, 3, 14, 50 and C).
Methods
A multi-center surveillance study for adult and adolescent community-acquired pneumonia was conducted prospectively in Beijing and Yan Tai between November 2010 and April 2012. A standardized data form was used to record clinical information. The viral DNA extracted from the clinical samples or adenovirus viral isolates were sequenced.
Results:
Among 969 cases, 48 (5%) were identified as adenovirus pneumonia. Six branches were clustered: HAdV-55 in 21; HAdV-7 in 11; HAdV-3 in 9; HAdV-14 in 4; HAdV-50 in 2 and HAdV-C in 1. Most HAdV-55 was identified during February and March. All the hypervariable region of the hexon genes of the 21 HAdV-55 strains was completely identical. Compared with other types (HAdV-7, 3, 14, 50 and C), patients due to HAdV-55 were about 10 years older (p=0.027) and had higher PSI score (p=0.030). Systemic blood pressure was also higher among patients in HAdV-55 group (p=0.006). Unilateral or bilateral consolidations were the most common radiological findings in both HAdV-55 group and other types (57.9% vs 36%). More than half of the patients were admitted to hospitals, oxygen therapy was given to 29.2% of the patients and two of them needed mechanical ventilation.
Conclusions
HAdV-55 has established itself as a major pneumonia pathogen among Chinese population and further surveillance and monitoring of this agent as a cause of CAP is warranted.
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