China: Undiagnosed Bleeding Disorder - Anhui province - possible bromadiolone poisoning

[Treyfish]

15 people in a village of Fuyang into the hospital poisoning incident to determine the initial murine poisoning
Poisoning is no life-threatening Fuyang relevant departments are investigating poisoning pathways

Time: 2016-12-05 05:18:30

A number of villagers appeared discomfort, to the hospital after the inspection found to be poisoning (newspaper December 3 has been reported) .According to the news, Yesterday, the reporter learned from the Taihe county government, this incident preliminary determination of suspected rat poisoning. Local government departments set up emergency response leading group, to investigate the incident. It is comforting that poisoned villagers are now stable vital signs, are not life-threatening.

[Patients] poisoning no life-threatening

Mr. Liang is the Taihe County, Xiao mouth town of the Soviet Union temple village, he is one of the victims of the poisoning incident. According to Mr. Liang recalled, November 23, his body suddenly changed. "When I got up that morning, I found a lot of bubbles on my lips, brushing my gums, my gums bleeding, my lower abdomen painful, and the most horrible thing about it being that I was urinating."

Mr. Liang and others to the hospital for medical treatment, was diagnosed with acute anticoagulant chemical poisoning. It is understood that the local villagers also appeared in the same symptoms, a blood examination to a hospital in Shanghai, identified as bromadiolone poisoning.

Reporter learned from the Taihe County Public Security Bureau, as of now, Sumiao natural village a total of 21 people suspected of poisoning symptoms of rat poisoning and hospitalization, of which An Affiliated Hospital of Medical treatment 4 (2 people have been discharged), Zhejiang Xiaoshan Hospital 1 Person, Taihe County People's Hospital 16 (1 person has been discharged). Another 15 people to the county hospital for examination, clotting time extended to varying degrees (one of the main symptoms of rat poisoning), not hospitalized. "Fortunately, the poisoning of patients with stable vital signs, no life-threatening." Police told reporters, "hospitalized patients with vitamin K1 detoxification treatment to liver drug adjuvant therapy, the effect is obvious, no other abnormalities."

[Investigation] part of the villagers found poisonous rat poison

It is understood that Taihe County, Xiao Town, Mao Zhuang Village Su Temple Village is located in the north of Xiao Town, population 1016 people. The village there dozens of rat poisoning after the incident, many local villagers in their own yard, the house sprinkled with lime powder, hoping to use this anti-bacterial anti-virus. "A few days time, dozens of villagers poisoning, we are more worried about fear of infectious diseases or other diseases." Local villagers said, "worried about the possibility of infection, we use lime powder, hoping to play the role of antibacterial antivirus . "

Poisoning incident, the local government departments to investigate this incident, the initial verdict of suspected rat poisoning, excluding the possibility of infectious diseases.

A medical examination in the field of blood test report, show poisoning in the blood of the big dragon, bromadiolone composition. It is reported that Dalong pure yellow white or off-white powder, more stable chemical properties at room temperature, can be stored for more than 2 years, on livestock, poultry and other highly toxic, slightly toxic to fish. Long for the second generation of anticoagulant rodenticides, is the most toxic anticoagulant one, with acute and chronic rodenticides of the dual characteristics. Bromadiolone and Dalong similar, but also a highly toxic rat poison.

Reporter was informed that the local government in the investigation found that some local villagers put poisonous drugs at home.

[Treatment] collection of drinking water and other food inspection

Poisoning were initially identified as suspected rat poisoning, then the rat poison is how to enter the villagers body? And why there will be more than 20 villagers at the same time poisoning?

Reporter learned from the Taihe County Government, Xiao mouth Su Temple natural village has been running water, the villagers are drinking tap water instead of well water. In addition, according to public security departments, the Department of Health and other departments of the survey, the local masses of the recent mass dinner, a common occupational exposure history, environmental health can still not found a large number of animal carcasses.

The county government received the county Weiwei situation report, immediately at 8:00 on December 3 to convene the county health planning Commission, the Public Security Bureau, the Agricultural Commission, the Market Authority, Xiao Town Government and other relevant units, convene an emergency disposal work conference , Decided to set up a leading group for emergency response, under the health relief, preliminary investigation of cases, to appease the stability control, publicity, pesticide clean-up investigation and other five working groups, the working group immediately rushed to the scene, focusing on the cause of the investigation, patient treatment, Patient follow-up, suspicion of the suspects and the emotional stability of the masses, and quickly take effective measures to ensure that the lives of the masses.

At present, Fuyang City, CDC has collected related food, drinking water, is investigating the poisoning path. http://ah.anhuinews.com/system/2016/...07519472.shtml

[alert]

Published Date: 2016-12-04 20:02:26
Subject: PRO/AH/EDR> Undiagnosed bleeding disorder - China: (AH) RFI
Archive Number: 20161204.4675611
UNDIAGNOSED BLEEDING DISORDER - CHINA: (ANHUI) REQUEST FOR INFORMATION
************************************************** ********************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org

Date: Sat 3 Dec 2016
Source: Xinhua [edited]

http://www.globaltimes.cn/content/1021746.shtml

Dozens of villagers in east China's Anhui province have fallen ill with symptoms similar to rodenticide poisoning, but investigators are yet to confirm the cause for their sickness.

21 people from 9 families in Xiaokou Township, Taihe County had been hospitalized as of Saturday [3 Dec 2016] with severe symptoms of poisoning, the county's health department said in a statement. Another 15 villagers had milder symptoms and were allowed to go home, it said.

The 1st 2 cases were reported on [25 Nov 2016], when LG and his wife were admitted to hospital with seizures, hematemesis, and blood in their urine. Doctors suspected that this was a result of consuming rat poison.

The subsequent investigation, however, found no traces of any harmful substance in samples of leftover food and water taken from their home in Maozhuang village. The couple had not dined out or been exposed to harmful chemicals. Similar symptoms were reported by many other villagers over the past week.

"My 4-year-old son was hospitalized on Thursday [1 Dec 2016]," said villager ZH. "The doctor said he had blood clotting problems."

The same problems were reported by Z's parents. Z, who works in a town 20-km away and is rarely home, showed no such symptoms in the checkup.

The disease prevention and control center in Fuyang City has joined the investigation, and it has taken samples of the villagers' food and water for further lab work.

--
Communicated by:
ProMED-mail

[There are a number of things other than rodenticides that could cause bleeding disorders. Hemophilia, and Von Willebrands disease are a few familiar diseases that come to mind. However, these are hereditary or familial diseases and are unlikely to make their presence known suddenly, across multiple people and locations.

Overdose of some drugs, such as aspirin, could cause bleeding; but again, such an event across multiple locations and people within a small timeframe is unlikely.

Leukemia, chemo, or radiation therapies are also possible causes of bleeding disorders. However, there would likely be medical records to back this up, and there seem to be none of these situations occurring with this disorder.

Diseases such as leptospirosis or Crimean-Congo hemorrhagic fever would have other clinical signs and available testing that would lead more rapidly to a diagnosis.

Yet, the food is testing negative for rodenticides. There are numerous rodenticides that cause clotting factors to decrease, so one has to wonder whether the tests performed on the food covered a wide range of these or only one or 2 compounds.

Exposure to some thrombocytopenic agent would seem likely to occur through a common food or water source. So perhaps there will be more of an investigation into which rodenticide compounds were tested for, and what food all these people may have had in common. If there is a chemical being passed through air or water handling systems, perhaps this should be investigated.

If someone has additional information on these cases or a definitive diagnosis, please let us know. - Mod.TG