Announcement

**sharon sanders** · December 17, 2013, 10:55 AM

Re: Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A(H10N8) in Jiangxi (December 17 2013): 1st reported human case ww

Also please see:

Complete Genome Sequence of an H10N8 Avian Influenza Virus Isolated from a Live Bird Market in Southern China - January 2012

**sharon sanders** · December 17, 2013, 10:56 AM

Re: Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A(H10N8) in Jiangxi (December 17 2013): 1st reported human case ww

HK CHP Notified Of Fatal H10N8 Infection In Jiangxi

Jiangxi Province ? Credit Wikipedia

# 8083

While we watch primarily for H7N9 and H5N1 avian influenza infections, over the years we?ve seen a handful of other avian strains infecting humans.

In 2003, an outbreak of H7N7 at a poultry farm in the Netherlands went on to infect at least 89 people (mostly mildly, but 1 death), and many more may have been infected subclinically.
In Egypt - in 2004 - 2 infants were shown to be infected by the H10N7 avian flu virus.
In 2006 1 person in the UK was confirmed to have contracted H7N3, and the following year, 4 people tested positive for H7N2 ? both following local outbreaks in poultry.
And in 2012, in EID Journal: Human Infection With H10N7 Avian Influenza, we learned of H10N7 avian influenza virus detected in two poultry abattoir workers in Australia from 2010. Although 7 abattoir workers reported symptoms, only 2 tested positive for the H10 virus.

We honestly don?t know how often these seldom seen influenza strains infect humans, as testing is rarely done. With the heightened alert for H7N9 in China, however, more testing that normal is going on, which probably explains why Hong Kong?s CHP has been notified of another `oddball? avian flu strain that infected, and killed, an immunocompromised patient in Jiangxi; H10N8.

CHP notified by NHFPC of human fatal case of avian influenza A(H10N8) in Jiangxi
The Centre for Health Protection (CHP) of the Department of Health (DH) today (December 17) received notification from the National Health and Family Planning Commission (NHFPC) of a human fatal case of avian influenza A(H10N8) affecting a woman aged 73 in Jiangxi. The immunocompromised patient with underlying illnesses was admitted to a local hospital on November 30 for treatment. Her clinical diagnosis was severe pneumonia and she passed away on December 6.
According to the relevant authority, the patient had visited a local live poultry market. Her home and close contacts, who are under medical surveillance, have remained asymptomatic and no abnormalities have been found so far.
"Influenza A(H10) is currently not a local statutorily notifiable infectious disease but the Public Health Laboratory Services Branch of the CHP is capable of detecting this virus by culture or genetic testing. No confirmed human cases have been recorded so far in Hong Kong," a spokesman for the CHP said.
The CHP will follow-up with the World Health Organization (WHO) and the Mainland health authorities to obtain more information on the case.
"Locally, enhanced disease surveillance, port health measures and health education against avian influenza have been proceeding. We will remain vigilant and maintain liaison with the WHO and relevant health authorities. Local surveillance activities will be modified upon the WHO's recommendations," the spokesman remarked.
All border control points have implemented disease prevention and control measures. Suspected cases of infectious disease will be immediately referred to public hospitals for follow-up investigation.
The spokesman urged travellers not to visit live poultry markets and avoid direct contact with poultry, birds and their droppings during travel. If contact has been made, they should thoroughly wash their hands with soap and water. If fever or respiratory symptoms develop, they should immediately wear facial masks, seek medical attention and reveal their travel history to doctors.
Members of the public should remain vigilant and are reminded to take heed of the following preventive advice against avian influenza:

* Poultry and eggs should be thoroughly cooked before eating;
* Wash hands frequently with soap, especially before touching the mouth, nose or eyes, handling food or eating; after going to the toilet or touching public installations or equipment such as escalator handrails, elevator control panels or door knobs; or when hands are dirtied by respiratory secretions after coughing or sneezing;
* Cover the nose and mouth while sneezing or coughing, and hold the spit with a tissue and put it into a covered dustbin;
* Avoid crowded places and contact with fever patients; and
* Wear a mask when respiratory symptoms develop or when taking care of fever patients.
The public may visit the CHP's avian influenza page (www.chp.gov.hk/en/view_content/24244.html) and its website (www.chp.gov.hk/files/pdf/global_statistics_avian_influenza_e.pdf) for more information on avian influenza-affected areas.
Ends/Tuesday, December 17, 2013
Issued at HKT 22:05

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**Giuseppe** · December 17, 2013, 12:04 PM

Re: Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A( H10N8 ) in Jiangxi (December 17 2013): 1st reported human case ww

[Source: China?s Jiangxi Province Health Department, full page in Chinese: (LINK). Automatic translation.]

Nanchang reported one case of severe pneumonia caused by the A(H10N8) avian influenza virus

Jiangxi Provincial Health Department www.jxwst.gov.cn 2013 ? 12 ? 17 / Source: Office of Emergency Management Office

In recent years, the Jiangxi Provincial health departments to increase influenza-like illness and unexplained cases of pneumonia monitoring efforts, monitoring has improved sensitivity, has monitored discovered H1, H3, H5, H7 and other influenza viruses, influenza and other respiratory infections and strengthen disease prevention and control work.

Recently, Nanchang detected by monitoring the cases of specimens in one case of influenza A virus, the China Disease Prevention and Control Center further testing identified as H10N8 avian influenza virus.

The Patient, a female, 73 years old, diagnosed as severe pneumonia, accompanied by high blood pressure, heart disease, myasthenia gravis and other basic diseases, immunity level is low, there is live poultry business market exposure history.

Patient on November 30, 2013 in a hospital for treatment of income Nanchang, December 6 due to respiratory failure, shock and death. All close contacts exception does not appear. Experts believe that the initial consideration of the case as a case of human infection with the virus that causes low-risk and spread.

According to experts, the influenza virus can be divided into A (A), B (B), propylene (C) III. Among them, the characteristics of influenza viruses can be classified according to influenza HxNx (H for the hemagglutinin protein, N is neuraminidase protein) were more than 140 subtypes.

Expert tips, winter and spring is the flu season, once flu-like symptoms should seek immediate medical attention. Maintaining wash their hands, cover your nose and mouth and other personal hygiene when coughing and sneezing. At the same time, avoid the slaughter of live poultry, livestock, and food to avoid contact with sick (dead) birds, animals.

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**Ronan Kelly** · December 17, 2013, 05:28 PM

Re: Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A( H10N8 ) in Jiangxi (December 17 2013): 1st reported human case

China reports first human case of H10N8 avian flu
Filed Under: AVIAN INFLUENZA (BIRD FLU)
Jim Wappes | Editorial Director | CIDRAP News | Dec 17, 2013

The woman had visited a live-poultry market, Hong Kong health officials said.

A 73-year-old woman in Jiangxi province in China has died from an H10N8 avian flu infection, Hong Kong's Centre for Health Protection (CHP) said today, the first report of that strain infecting humans.

The woman, whose immune system was compromised, had an underlying illness and had visited a live-poultry market, CHP reported in a statement. She was admitted to a local hospital on Nov 30, was diagnosed as having severe pneumonia, and died Dec 6.

China's National Health and Family Planning Commission confirmed the case. The woman's close contacts are under medical surveillance but have as yet remained asymptomatic.
...

China reports first human case of H10N8 avian flu

http://www.cidrap.umn.edu/news-perspective/2013/12/china-reports-first-human-case-h10n8-avian-flu

**Pathfinder** · December 18, 2013, 09:27 PM

Re: Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A( H10N8 ) in Jiangxi (December 17 2013): 1st reported human case

Hongkongers warned to avoid mainland wet markets as H10N8 bird flu kills woman

PUBLISHED : Wednesday, 18 December, 2013, 11:21pm
UPDATED : Thursday, 19 December, 2013, 8:11am
...
The professor, Chen Ze, of the Shanghai Institute of Biological Products, a research arm of a state-owned pharmaceutical firm, said H10N8, which was previously found in wild birds, had mutated to infect humans.

"There is a chance of more cases of human infection in the future," said Chen, who in April warned of the threats from H10N8 and H6N6 amid the initial spread of human H7N9 cases.

Chen and his team isolated the H10N8 virus from the Dongting Lake wetland in 2007. Tests on mice found that the virus easily infected mammals.

"Our findings showed the virus was capable of infecting humans and it has the capability of mammal-to-mammal transmission, but whether there is going to be human-to-human transmission is hard to tell at the moment," said Chen.

He said the case for closing live poultry markets on the mainland had become stronger, at least in flu season, to reduce risks.
...
Jiangxi has yet to close live poultry markets or cull any birds because of the woman's death.
...

zhttp://www.scmp.com/news/hong-kong/article/1385394/hongkongers-warned-avoid-mainland-wet-markets-h10n8-bird-flu-kills

**Pathfinder** · December 18, 2013, 09:43 PM

Re: Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A( H10N8 ) in Jiangxi (December 17 2013): 1st reported human case

Translation Google

73-year-old woman in Jiangxi H10N8 infected with H7N9 deaths not directly related

At 09:11 on December 19 2013 Source: China News Network Author: HE Han Fu draft selection: Wang Yingying

According to Jiangxi Provincial Health Department of the contents of a patient suffering from H10N8 avian influenza for older women, 73-year-old, 6 December due to respiratory failure, shock and death.
　　
Jiangxi Provincial Health Department Emergency Management Office, said, Nanchang detected by monitoring influenza virus cases in which specimens by the China Disease Prevention and Control Center further testing identified as H10N8 avian influenza virus.
　　
National Health and Family Planning Commission said that after detection analysis, H10N8 avian influenza virus causes a low risk of human infection and transmission, and not directly related to H7N9.
　　
The first deaths worldwide
　　
Patients with clinical diagnosis of these victims of severe pneumonia, accompanied by high blood pressure, heart disease, myasthenia gravis and other underlying disease, low immunity levels. Patients on November 30, 2013 in a hospital for treatment of income Nanchang, December 6 due to respiratory failure, shock and death. Patients visited the live bird market, live poultry business market exposure history. All close contacts exception does not appear. Experts believe that the initial consideration of the case as a case of human infection with the virus that causes low-risk and spread.
　　
It is understood that this is the world's first human infection H10N8 deaths. Jiangxi Provincial Health Department in April this year, also informed Nanchang hospital treated a 69-year-old male patient, confirmed the first case of human infection with H7N9 avian influenza suspected cases.
　　
Interpersonal communication is not yet confirmed
　　
Deputy director of the Shanghai Public Health Clinical Center, the long-term management of Professor Lu Hongzhou study of infectious diseases in the interview with this reporter, said that for now, this event also is the case in Jiangxi, still can not prove that this new virus can spread from person to person. However, Lu Hongzhou was emphasized H10N8 risk.

"Although elderly patients themselves and accompanied by other age-related diseases, but health authorities must be vigilant, to be responsible for the safety of the public."
　　
Virus expert Chan analysis, H10N8 and H6N6 avian influenza virus is very easy to infect mammals, but no two of avian influenza infection in humans reported. Lu Hongzhou said that at this stage of the H10N8 virus H7N9 prevention and control of basic or reference to the practice, including the use of Tamiflu.

zhttp://news.eastday.com/c/20131219/u1a7839112.html

**Pathfinder** · December 19, 2013, 10:28 PM

Re: Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A( H10N8 ) in Jiangxi (December 17 2013): 1st reported human case

Translation Google

Beijing CDC: H10N8 low risk of transmission of the public need not panic

December 20, 2013 06:45:00 Source: Beijing Morning News
　　
Morning News (Reporter Xu Jingjing) for Jiangxi informed case of human infection of bird flu H10N8, yesterday, the Beijing Municipal Center for Disease Control issued health tips said, H10N8 avian influenza virus leads to a lower risk of human infection and spread. There is no evidence that there is a risk of large-scale spread of the virus, so people do not panic.
　　
December 17 this year, Health Department of Jiangxi Province, one case of human infection with avian influenza H10N8 cases , this case is the first case of human infection with avian influenza H10N8. Patients, female, 73 years old, diagnosed as severe pneumonia, accompanied by high blood pressure, heart disease, myasthenia gravis and other basic diseases, immunity level is low, there is live bird markets exposure history. Patients had revenue this year on November 30 in a hospital for treatment of Nanchang, December 6 due to respiratory failure, shock and death. All close contacts exception does not appear. Nanchang is detected by monitoring the cases in one case of influenza A virus specimens by the China Disease Prevention and Control Center further testing identified as H10N8 avian influenza virus.
　　
In this regard, the Beijing Municipal Center for Disease Control said yesterday, after a literature search of staff of the center, before the man was not found infected with bird flu virus reported H10N8. H10N8 avian influenza virus, Influenza A virus subtype H10N8. Studies have shown that, H10N8 avian influenza virus among poultry in the long-term presence of the virus in poultry is low pathogenicity, and can infect mammals.

Preliminary analysis of the case for the H10N8 avian influenza virus from cases of human infection, the virus that causes lower risk of human infection and spread. There is no evidence that the risk of large-scale spread of the virus.
　　
However, the CDC also reminded the public to prevent H10N8 avian influenza and other respiratory diseases, to do all aspects of prevention and control measures. Minimize unnecessary contact with livestock, with special attention to avoid contact with dead poultry. When eating poultry eggs to fully cooked. When traveling abroad, you should try to avoid contact with wild birds or wild birds into the habitat.

zhttp://big5.xinhuanet.com/gate/big5/news.xinhuanet.com/local/2013-12/20/c_125887810.htm

**Giuseppe** · December 26, 2013, 03:45 AM

Re: Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A( H10N8 ) in Jiangxi (December 17 2013): 1st reported human case

[Source: World Health Organization, Representative Office in China, full page: (LINK).]

Avian influenza A (H10N8)

Key facts

The WHO has been officially notified by the Chinese health authorities that avian influenza A (H10N8) has been detected in a single patient with severe pneumonia.
The patient is a 73-year old female from Jiangxi Province, China. She was hospitalized on November 30 and died on December 6.
This is the first ever report of H10N8 isolated from a patient.
The patient visited a live bird market four days before date of onset. She had many underlying medical conditions (immunocompromised).
The family members and other contacts had no symptoms and no other similar cases were detected in the area.
The fact that the virus was isolated from a patient and reported through active surveillance by the Chinese health authorities is a sign that the surveillance system is working well.
The specific source of the infection is unknown. As wild birds/poultry have been known to carry this virus, further sporadic cases may be detected.
While the investigation is ongoing, including contact tracing and enhanced surveillance, so far, there is no evidence of sick contacts or human-to-human transmission.
WHO is in contact with the national authorities and is following closely the event and will communicate important updates as they become available.

What we know

Although China has previously detected H10N8 in wild and domestic birds, this is the first ever report of H10N8 isolated from a patient. Given the potentially unpredictable behaviour of influenza viruses, vigilance and close monitoring is needed.
Outside of China, based on available literature, the virus had been detected in birds since 1965 in at least six countries (Italy, USA, Canada, South Korea, Sweden and Japan).
Human infections with influenza H10N7 subtype viruses have been previously reported from Egypt and Australia. All these patients presented with mild clinical signs and recovered.
The Chinese government is actively investigating this event and has heightened disease surveillance for early detection, prevention and control measures.
Given the increase in ILI and SARI surveillance, testing, and subtyping of influenza A positive specimens, especially in China, it is not unexpected to start to detect human infections with a variety of non-seasonal influenza subtypes.

WHO action

WHO is closely monitoring the situation and facilitating information sharing with Member States through the International Health Regulations.
WHO is collaborating with animal health colleagues to identify a possible animal source of the virus and assess the health risks.
WHO does not advise special screening at points of entry with regard to this event, nor does it recommend that any travel or trade restrictions be applied.

WHO?s public health advice

Avoid contact with sick or dead poultry. Keep children away from poultry.
Avoid touching any surfaces that may have been contaminated with poultry feces or blood.
Do not eat raw or undercooked poultry. Cook poultry to internal temperature of 70?C (until meat is not pink in the centre) and do not touch cooked meat with raw meat.
Clean cooking implements that have been in contact with raw meat before re-using.
Wash hands regularly, especially after handling poultry, while cooking and before eating.
Cover your mouth and nose when you cough or sneeze.
WHO does not recommend any specific measures be applied to travellers at this time.
Poultry, poultry products (eggs) and pork can be safely consumed provided they are properly cooked and properly handled during food preparation.

For more information, please contact

Helen Yu, Communications Officer, WHO in China, Office Tel: +86 10 65327191 ext 81275, Mobile: 13911205167, Email: yuji@wpro.who.int

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Announcement

Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A( H10N8 ) in Jiangxi (December 17 2013): 1st reported human case

Hong Kong, CHP notified by NHFPC of human fatal case of avian influenza A( H10N8 ) in Jiangxi (December 17 2013): 1st reported human case

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