Ducks dying of new disease in China and Thailand - novel flavivirus confirmed?

[alert]

I would assume that H5N1 has been excluded...

http://www.promedmail.org/pls/apex/f?p=2400:1001:1603888298898497::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,89607

Archive Number 20110802.2330
Published Date 02-AUG-2011
Subject PRO/AH/EDR> Undiagnosed die-off, ducks - China, Thailand: RFI

UNDIAGNOSED DIE-OFF, DUCKS - CHINA, THAILAND: REQUEST FOR INFORMATION
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<http://www.promedmail.org>
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International Society for Infectious Diseases
<http://www.isid.org>

Date: Tue 2 Aug 2011
From: Arnon Shimshony <arnon@promedmail.org> [edited]


According to a reliable source, mass mortality in duck breeding
flocks, reaching very large dimensions, has been observed recently in
China; a similar event was later observed in Thailand. Though no
further details (age groups, clinical signs, post-mortem changes, etc)
have become available, the event was considered by the source to be an
emerging (new?) infectious (viral?) disease.

Any available information -- confirmatory or otherwise -- and
complementary epidemiological, diagnostic, and/or geographical data,
will be much appreciated.

--
Arnon Shimshony
ProMED-mail Animal Disease and Zoonoses Moderator
<promed@promedmail.org>

[Vibrant62]

Re: Ducks dying of unknown disease in China and Thailand - new viral disease suspected?

Recent reports from Cambodia/ Vietnam have indicated a new substrain of H5N1 that escapes current vaccine protection (2.3.2 I beleive). I would have thought this must be a high probability here?

[alert]

Re: Ducks dying of unknown disease in China and Thailand - new viral disease suspected?

Recent reports from Cambodia/ Vietnam have indicated a new substrain of H5N1 that escapes current vaccine protection (2.3.2 I beleive). I would have thought this must be a high probability here?

I would think that H5N1 isn't even the only avian influenza that would have been considered (H7 and H9 have been reported in the area that I know of), so if the local authorities suspect a new virus, I would presume that the birds are negative for all strains of Influenza A.

But it is a very vague report nonetheless...

[Treyfish]

Undiagnosed die-off, ducks - china, thailand: Request for information

************************************************** *******************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Tue 2 Aug 2011
From: Arnon Shimshony <arnon@promedmail.org> [edited]


According to a reliable source, mass mortality in duck breeding
flocks, reaching very large dimensions, has been observed recently in
China; a similar event was later observed in Thailand. Though no
further details (age groups, clinical signs, post-mortem changes, etc)
have become available, the event was considered by the source to be an
emerging (new?) infectious (viral?) disease.

Any available information -- confirmatory or otherwise -- and
complementary epidemiological, diagnostic, and/or geographical data,
will be much appreciated.

--
Arnon Shimshony
ProMED-mail Animal Disease and Zoonoses Moderator
<promed@promedmail.org>
http://www.promedmail.org/pls/otn/f?..._ID:1000,89607

[alert]

Re: Ducks dying of unknown disease in China and Thailand - new viral disease suspected?

And there we go. Merged and renamed.

http://www.promedmail.org/pls/apex/f?p=2400:1001:378063722481812::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,89611

Archive Number 20110802.2332
Published Date 02-AUG-2011
Subject PRO/AH/EDR> Duck egg-drop syndrome - China (02): BYD flavivirus, emerging

DUCK EGG-DROP SYNDROME - CHINA (02): BYD FLAVIVIRUS, EMERGING
************************************************** ***********
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

Date: Tue 2 Aug 2011 (accessed)
Source: Virology, Rapid Communication, Article in Press, Corrected
Proof, Available online 30 Jun 2011 [edited]
<http://www.sciencedirect.com/science/article/pii/S0042682211002674>
(Subscription)


Re: Undiagnosed die-off, ducks - China, Thailand
------------------------------------------------
[Following our earlier RFI, we have been informed that the recent
observations on disease and death affecting breeding duck flocks in
China and Thailand, are in fact caused by an emerging BYD flavivirus
infection, reported on 3 Apr 2011, ProMED archive 20110403.1037. The
following abstract of an article in press adds background information.
- Mod.AS]

Abstract
--------
During investigations into an outbreak of egg production decline,
retarded growth, and even death among ducks in Southeast China, a
novel Tembusu virus strain named _Tembusu virus Fengxian 2010
(FX2010)_ was isolated. This virus replicated in embryonated chicken
eggs and caused embryo death. In cross-neutralization tests, antiserum
to the partial E protein of Tembusu virus Mm1775 strain neutralized
FX2010, whereas antiserum to Japanese encephalitis virus did not.
FX2010 is an enveloped RNA virus of approximately 45&#194;*50 nm in
diameter.

Sequence analysis of its E and NS5 genes showed that both genes share
up to 99.6 percent nucleotide sequence identity with Baiyangdian
virus, and up to 88 percent nucleotide sequence identity with their
counterparts in Tembusu virus. FX2010 was transmitted without
mosquito, and caused systemic infection and lesions in experimentally
infected ducks. These results indicate that FX2010 and BYD virus are
newly emerged Tembusu virus strains that cause an infectious disease
in ducks.

[Byline: Pixi Yan, Youshu Zhao, Xu Zhang, Dawei Xu, Xiaoguang Dai,
Qiaoyang Teng, Liping Yan, Jiewen Zhou, Xiwen Ji, Shumei Zhang,
Guangqing Liu, Yanjun Zhou, Yoshihiro Kawaoka, Guangzhi Tong & Zejun
Li]

--
Communicated by:
ProMED-mail
<promed@promedmail.org>

[The following passage is copied from the discussion paragraph (for
the numerous included references, see the original paper):

"Only a limited number of flaviviruses have been reported to cause
duck infectious diseases, although many flaviviruses, whose
pathogenicity for animals is unknown, have been isolated from
mosquitoes, ticks, and bats. Tembusu virus was isolated from
mosquitoes in Kuala Lumpur in 1955. Since then, Tembusu virus has been
isolated from the _Culex_ species of mosquitoes in Malaysia and
Thailand. Encephalitis and retarded growth of chicks caused by a
Tembusu virus was first reported in Malaysia. In addition, high levels
of serum-neutralizing antibody against Tembusu virus have been
reported in humans in Malaysia, although a disease associated with
Tembusu virus infection has not yet been reported. It remains unknown
whether FX2010-like Tembusu virus can infect humans [sic; it says just
above "high levels of serum-neutralizing antibody against Tembusu
virus have been reported in humans in Malaysia"], although the virus
has spread widely in Southeast China. However, given that the areas
where FX2010-like Tembusu virus is circulating are among the most
densely populated areas in the world, this virus may pose a threat to
human health in the future. We recommend that human serological
surveillance be conducted in FX2010-like Tembusu virus-circulating
areas as soon as possible."

The abstract of an earlier paper on this emerging duck disease, titled
'Duck Egg-Drop Syndrome Caused by BYD Virus, a New Tembusu-Related
Flavivirus,' was included and discussed in ProMED archive
20110403.1037. The virus isolated was named Baiyangdian (BYD) virus
(BYDV) after the name of the region where the virus was 1st isolated.

Any updated information on the current distribution of BYD and on
measures applied to prevent its transboundary spread by international
trade of breeding material, will be appreciated. Vigilance pertaining
to its possible (hopefully, to be excluded) zoonotic potential is
prescribed. - Mod.AS]

[see also:
Undiagnosed die-off, ducks - China, Thailand: RFI 20110802.2330
Duck egg-drop syndrome - China: BYD flavivirus, emerging
20110403.1037]

[sharon sanders]

Re: Ducks dying of unknown disease in China and Thailand - new viral disease suspected?

Re: Undiagnosed die-off, ducks - China, Thailand
------------------------------------------------
[Following our earlier RFI, we have been informed that the recent
observations on disease and death affecting breeding duck flocks in
China and Thailand, are in fact caused by an emerging BYD flavivirus
infection, reported on 3 Apr 2011, ProMED archive 20110403.1037. The
following abstract of an article in press adds background information.
- Mod.AS]

I put a question mark in the title. It is not clear to me that the current die off is connected in any way to an April incident.

[sharon sanders]

Re: Ducks dying of new disease in China and Thailand - novel flavivirus confirmed?

In Zhejiang province -

Hundreds of ducks die suddenly

Source: Zhejiang Online - Dongyang Daily At 09:02 on July 26, 2011
Add a comment ( 0 )Copy linkPrint Large in small
　　Correspondent correspondent Jiang Huaxia Ye Ting 　　Town Song Jiang Anxi village under the Yu Shenghua beach side of the river in the village

snip

Next, they found that many ducks began wrong, "First down, thump a few times, then upward, in a moment he died." Yu Shenghua said to the seven or eight o'clock at night, a group of ducks died. 　　Yesterday morning, Yu Shenghua wife in a sand path between fields in the vicinity found a plastic bag, containing some white powder, have a pungent odor. Yu Shenghua think ducks will eat the "white powder" was poisoning? 　　Yu Shenghua reported the matter to the police station Weishan, took police to the scene evidence. Attendance police said they found at the scene of the dead duck in the number of victims is not to say that much. Meanwhile, Yu Shenghua assistance to the City Animal Husbandry and Veterinary Bureau, the Bureau Testing Center staff dissected Yu Shenghua brought two dead duck. Supervision Division of Animal Epidemic Prevention Bureau Lu Chao Hang said, according to the anatomical situation, the duck may be suffering from a "bird out of defeat," "bird out of defeat" is a disease caused by a viral infection, highly contagious, high mortality rate. 　　For the City, Animal Husbandry and Veterinary Bureau said, Yu Shenghua not fully recognized, "Why do ducks have white powder in a sudden it?" 　　Yesterday afternoon, the City Animal Husbandry and Veterinary Bureau staff made a special trip arrived at the duck farm, "Judging from the scene , the duck does not look like poisoning, suffering from "bird out of defeat," the more likely. "in order to prevent infection of other ducks, they duck farm was disinfected, dead duck on treatment and disposal, according to the" bird out of defeat "symptoms, returned to the duck farm allotment of the relevant drugs.

more..

http://roll.sohu.com/20110726/n314544868.shtml

[sharon sanders]

Re: Ducks dying of new disease in China and Thailand - novel flavivirus confirmed?

machine translation -

In Jiangsu province -

Inexplicable death of tens of thousands of ducks

At 3:31 on July 27, 2011
Source: Modern Express Font Size: T | T0 participants 0 comments Print Forward
Veterinary Station, university experts did not find out what the reason

Yangzhou Hanjiang coated master is a Yang Yahu Oasis town, recently he was very sad, from July 8, he began breeding flocks of ducks began to die somehow, has killed more than 10,000 ducks, more than 40 million loss dollars. Why a duck flocks of death, painted the master station to the local veterinary advice, but also hired the experts in Yangzhou University, but for the cause of death has still not known. Yesterday, reporters rushed to the Oasis town Yaowancun coated master home, in his leadership, the reporter came to the master painted a duck pond. Still some distance away from the duck pond, the reporter smelled a foul odor. Closer, the sight is really miserable. Pond, water everywhere, dead duck, dead duck like a "concentration camp."

According to James the master, from the start on July 8, he found the duck pond in the sudden death groups. "One day to death hundreds of thousands." Painted the master that the water quality reasons, they put the rest of the duck duck pond to another, but still to no avail.

more..

http://finance.ifeng.com/money/roll/20110727/4315339.shtml

[alert]

Re: Ducks dying of new disease in China and Thailand - novel flavivirus confirmed?

http://wwwnc.cdc.gov/eid/article/17/10/10-1890_article.htm

Tembusu Virus in Ducks, China
Article Contents
The StudyConclusionsAcknowledgmentsReferencesFigure 1Figure 2TableZhenzhen Cao, Cun Zhang, Yuehuan Liu, Weicheng Ye, Jingwen Han, Guoming Ma, Dongdong Zhang, Feng Xu, Xuhui Gao, Yi Tang, Shaohua Shi, Chunhe Wan, Chen Zhang, Bin He, Mengjie Yang, Xinhao Lu, Yu Huang, Youxiang Diao, Xuejun Ma, and Dabing Zhang
Author affiliations: Key Laboratory of Zoonosis of Ministry of Agriculture, Beijing, People?s Republic of China (Z. Cao, G. Ma, Dongdong Zhang, Dabing Zhang); China Agricultural University, Beijing (Z. Cao, G. Ma, Dongdong Zhang, Dabing Zhang); Zhejiang Academy of Agricultural Sciences, Hangzhou, People?s Republic of China (Cun Zhang, W. Ye); Beijing Academy of Agriculture and Forestry Sciences, Beijing (Y. Liu, J. Han); Beijing University of Agriculture, Beijing (F. Xu); Shandong Agricultural University, Taian, People?s Republic of China (X. Gao, Y. Tang, Y. Diao); Fujian Academy of Agricultural Sciences, Fuzhou, People?s Republic of China (S. Shi, C. Wan, Y. Huang); Chinese Center for Disease Control and Prevention, Beijing (Chen Zhang, B. He, M. Yang, X. Ma); Yuyao Municipal Institute of Poultry Disease, Yuyao, People?s Republic of China (X. Lu)
Suggested citation for this article

Abstract
In China in 2010, a disease outbreak in egg-laying ducks was associated with a flavivirus. The virus was isolated and partially sequenced. The isolate exhibited 87%?91% identity with strains of Tembusu virus, a mosquito-borne flavivirus of the Ntaya virus group. These findings demonstrate emergence of Tembusu virus in ducks.
From June through November 2010 in the People?s Republic of China, a disease characterized by a sudden onset was observed on many egg-laying and breeder duck farms. Egg production in affected ducks dropped severely within 1?2 weeks after disease onset. Other consistent signs included acute anorexia, antisocial behavior, rhinorrhea, diarrhea, ataxia, and paralysis. Rate of illness was usually high (up to 90%), and mortality rates varied from 5% to 30%. From affected ducks we isolated and identified a Tembusu virus (TMUV).

[snip]