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China - H7N9 prevention: Heilongjiang Province to strengthen supervision of illegal hunting of migratory birds and other wildlife

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  • China - H7N9 prevention: Heilongjiang Province to strengthen supervision of illegal hunting of migratory birds and other wildlife


    http://en.wikipedia.org/wiki/Heilongjiang


    Heilongjiang Province, to strengthen the hunting of wild bird protection containment
    Published: (2013-04-27)

    At present, Heilongjiang Province, has entered the spring migratory period, really good job in the work of the H7N9 avian influenza prevention and control of epidemic monitoring, the Provincial Forestry Department recently issued a notice called for further strengthening of birds and other wildlife protection and management, and resolutely curb illegal hunting abuse of food birds and other wild animals illegal activities and to prevent the occurrence and spread of highly pathogenic avian influenza spread.

    Every spring has a large number of migratory birds migrating from the south to the province breeding, stop this wild animal epidemic disease epidemic prevention and control situation is very grim. Provincial Forestry Department requirements, in the main distribution area for migratory birds and other wild animals, breeding habitat, migratory stopover, migratory channels, cluster activities area, make great efforts to carry out patrol and guard work arrangements patrol one by one, to closely monitor illegal Molecular steal the spreading of toxic drugs to poison the birds. Protection of lack of supervision of illegal hunting of migratory birds and other wildlife abuse of food or lead to the spread of the disease, shall be subject to administrative accountability on the responsibility and the responsibility of leadership. Concentrated wildlife, people and wildlife in close contact with high-risk area, you want to set the warning signs. Should work together with industry and commerce, public security departments to do a good job of live birds and their products hidden danger of the market, and and timely joint special enforcement action. Enforcement and inspection efforts to increase tourist attractions surrounding shops, restaurants, hotels, Flower Market and wildlife products operating distribution center.
    Strengthen the monitoring of domestication and breeding places and hidden danger. Now until the end of October, around the birds and other wildlife protection cases, investigated and dealt with the implementation of weekly system, and concealed behavior to persons responsible for delaying the report.

    The province has initially formed a province-wide monitoring and prevention and control system, relying on the existing wildlife protection management system, nature reserves, bird banding stations, wildlife farms, the province has established 70 wild animal epidemic disease Stations. Provincial Forestry Department also held eight more than 800 people in the province's wild animal epidemic disease monitoring and prevention and control of technical training courses, established the popular features of the avian influenza, monitoring, prevention and control measures, warning area sampling and sound processing operations, animal traces and species identification training, enhancing the overall wild animal epidemic disease monitoring and prevention and control capabilities. (A21)
    Source: Heilongjiang Daily

    "Safety and security don't just happen, they are the result of collective consensus and public investment. We owe our children, the most vulnerable citizens in our society, a life free of violence and fear."
    -Nelson Mandela

  • #2
    Re: China - H7N9 prevention: Heilongjiang Province to strengthen supervision of illegal hunting of migratory birds and other wildlife

    Historical pH1N1
    from
    Heilongjiang Province



    pH1N1 sequences from that region are sparse (12) and not current (2011 Latest) but do match contemporaneous circulation in Beijing, Guangdong, Jiangsu and Hunan indicating that the area gets similar transmission patterns. Notable HA polymorphisms include Vaccine Escape marker 158E, Receptor Binding Site 194I / 225G / 226R and 245I (Novel to pH1N1).

    Hemagglutinin Polymorphisms from this region on pH1N1 match Emergent H7N9 at -2I, 5K, 116K & 447K and share homology with ΣH7N7 at 17 of 45 distinct changes across 12 sequences. Incidentally, HA 116K disappeared from Pandemic H1N1 sequences after 5 showings up to March 2010 (3 Asia / 1 Africa / 1 US) and re-emerged in a pH1N1 deposit made by the US CDC a few days ago from a human sample taken in late March 2013 in the United States, a polymorphism not present for 3 years in humans.

    The HA and NA each shows trace mixture, potentially indicating co-infection. The NA segment across these 12 sequences is divergent. pH1N1 and Emergent H7N9 share Neuraminidase homology at 74I.

    Although the genetic tracking information is dated for this region, evidence appears that human disease has been influenced in the past by avian strains in a pattern suggestive of viral reservoir interchange at the avian stage prior to human infection. The database records wild avian H1N1 sharing Polymerase with wild avian H7N9 in 2011 common time and location demonstrating compatibility of modern diverse serotype backgrounds. We've all witnessed the serotype variation of the ill-fitting, BLAST-proposed emergent H7N9 ancestry trees. The new genotype is likely to have numerous viable options. Given migration systems and this genetic evidence, Heilongjiang Province is certainly a candidate to receive the next step in emergent H7N9 genetic maturation.

    We'd like to ask if Heilongjiang is also having equine / canine viral outbreaks of pathogens not generally associated with Influenza.

    HA Polymorphisms

    . . . . ChinaHeilongjiangLongshaSWL1181_C3_3M_2011_04_08 (
    . . . . . . . . GISAID HA EPI330849
    . . . . . . . . GISAID Isolate EPI_ISL_94652
    . . . . . . . . 14 Polymorphisms (6 Amino and 8 Silent)
    . . . . . . . . #6M [H9N2],
    . . . . . . . . syn34N (AAt),
    . . . . . . . . syn108L (cTG) [H5N1],
    . . . . . . . . . . . . . . . . . . [avH1N1farm],
    . . . . . . . . syn122K (AAa),
    . . . . . . . . 146G,
    . . . . . . . . 188T,
    . . . . . . . . 200T,
    . . . . . . . . syn338G (GGc),
    . . . . . . . . 377K,
    . . . . . . . . syn405K (AAg) [Emergent H7N9],
    . . . . . . . . . . . . . . . . . . .[H5N1],
    . . . . . . . . 454N,
    . . . . . . . . syn465N (AAt),
    . . . . . . . . syn474C (TGt),
    . . . . . . . . syn538F (TTt))

    . . . . ChinaHeilongjiangXiangfangSWL1528_E2_2M_2011_03_04 (
    . . . . . . . . GISAID HA EPI330673
    . . . . . . . . GISAID Isolate EPI_ISL_94630
    . . . . . . . . 15 Polymorphisms (9 Amino and 6 Silent)
    . . . . . . . . #6M [H9N2],
    . . . . . . . . syn34N (AAt),
    . . . . . . . . syn122K (AAa),
    . . . . . . . . 146G,
    . . . . . . . . 158E,
    . . . . . . . . syn173G (GGa),
    . . . . . . . . 188T,
    . . . . . . . . 194I,
    . . . . . . . . 200T,
    . . . . . . . . 225G,
    . . . . . . . . syn338G (GGc),
    . . . . . . . . 377K,
    . . . . . . . . 454N,
    . . . . . . . . syn465N (AAt),
    . . . . . . . . syn538F (TTt))

    . . . . ChinaHeilongjiangXiangyangSWL196_C2_3M_2011_03_03 (
    . . . . . . . . GISAID HA EPI330300
    . . . . . . . . GISAID Isolate EPI_ISL_94579
    . . . . . . . . 5 Polymorphisms (5 Amino and 0 Silent)
    . . . . . . . . 131P,
    . . . . . . . . 210N [H5N1],
    . . . . . . . . . . . . .[H9N2],
    . . . . . . . . . . . . .[avH1N1farm],
    . . . . . . . . 211R [H7N7],
    . . . . . . . . . . . . .[H9N2],
    . . . . . . . . . . . . .[avH1N1farm],
    . . . . . . . . . . . . .[H13N2],
    . . . . . . . . 245I [sH3N2],
    . . . . . . . . . . . . [H9N2],
    . . . . . . . . . . . . [H7N9 LAd],
    . . . . . . . . 447K [Emergent H7N9],
    . . . . . . . . . . . . [sH3N2])

    . . . . ChinaHeilongjiangXiangfang196_C2C1_2011_03_03 (
    . . . . . . . . GISAID HA EPI320020
    . . . . . . . . GISAID Isolate EPI_ISL_90926
    . . . . . . . . 5 Polymorphisms (5 Amino and 0 Silent)
    . . . . . . . . 131P,
    . . . . . . . . 210N [H5N1],
    . . . . . . . . . . . . .[H9N2],
    . . . . . . . . . . . . .[avH1N1farm],
    . . . . . . . . 211R [H7N7],
    . . . . . . . . . . . . .[H9N2],
    . . . . . . . . . . . . .[avH1N1farm],
    . . . . . . . . . . . . .[H13N2],
    . . . . . . . . 245I [sH3N2],
    . . . . . . . . . . . . [H9N2],
    . . . . . . . . . . . . [H7N9 LAd],
    . . . . . . . . 447K [Emergent H7N9],
    . . . . . . . . . . . . [sH3N2])

    . . . . ChinaHeilongjiangXiangfang191_E1E3_2011_01_08 (
    . . . . . . . . GISAID HA EPI325576
    . . . . . . . . GISAID Isolate EPI_ISL_93610
    . . . . . . . . 14 Polymorphisms (7 Amino and 7 Silent)
    . . . . . . . . #6M [H9N2],
    . . . . . . . . syn21T (ACc) [H7N7],
    . . . . . . . . syn34N (AAt),
    . . . . . . . . syn47L (tTA),
    . . . . . . . . syn122K (AAa),
    . . . . . . . . 146G,
    . . . . . . . . 188T,
    . . . . . . . . 200T,
    . . . . . . . . 226R,
    . . . . . . . . syn338G (GGc),
    . . . . . . . . 377K,
    . . . . . . . . 454N,
    . . . . . . . . syn465N (AAt),
    . . . . . . . . syn538F (TTt))

    . . . . ChinaHeilongjiangLongshaSWL19_C4_27F_2010_01_13 (
    . . . . . . . . GISAID HA EPI258044
    . . . . . . . . GISAID Isolate EPI_ISL_75039
    . . . . . . . . 4 Polymorphisms (1 Amino and 3 Silent)
    . . . . . . . . 116K [Emergent H7N9],
    . . . . . . . . syn175E (GAg) [avH1N1],
    . . . . . . . . syn177L (CTt) [H9N2],
    . . . . . . . . . . . . . . . . . . [avH1N1farm],
    . . . . . . . . . . . . . . . . . . [H6N1],
    . . . . . . . . . . . . . . . . . . [H10N7],
    . . . . . . . . syn541C (TGt) [Emergent H7N9])

    . . . . ChinaHeilongjiangJianhuaSWL18_C4_11M_2010_01_09 (
    . . . . . . . . GISAID HA EPI258040
    . . . . . . . . GISAID Isolate EPI_ISL_75038
    . . . . . . . . 4 Polymorphisms (1 Amino and 3 Silent)
    . . . . . . . . 131P,
    . . . . . . . . syn177L (CTt) [H9N2],
    . . . . . . . . . . . . . . . . . . [avH1N1farm],
    . . . . . . . . . . . . . . . . . . [H6N1],
    . . . . . . . . . . . . . . . . . . [H10N7],
    . . . . . . . . syn184H (CAc),
    . . . . . . . . syn359E (GAa) [H5N1, avH1N1, H13N2])

    . . . . ChinaHeilongjiangXiangfangSWL1970_C2_20F_2009_12_3 0 (
    . . . . . . . . GISAID HA EPI257580
    . . . . . . . . GISAID Isolate EPI_ISL_74923
    . . . . . . . . 7 Polymorphisms (2 Amino and 5 Silent)
    . . . . . . . . syn255R (AGg) [avH3N2],
    . . . . . . . . 265E [avH1N1],
    . . . . . . . . syn268I (ATc),
    . . . . . . . . 377K,
    . . . . . . . . syn413K (AAg),
    . . . . . . . . syn429L (TTa),
    . . . . . . . . syn432L (TTa))

    . . . . ChinaHeilongjiangLongshaSWL1424_C1_22F_2009_12_19 (
    . . . . . . . . GISAID HA EPI257584
    . . . . . . . . GISAID Isolate EPI_ISL_74924
    . . . . . . . . 2 Polymorphisms (0 Amino and 2 Silent)
    . . . . . . . . syn175E (GAg) [avH1N1],
    . . . . . . . . syn541C (TGt) [Emergent H7N9])

    . . . . ChinaHeilongjiangJianhuaSWL1574_C1_4F_2009_12_14 (
    . . . . . . . . GISAID HA EPI257456
    . . . . . . . . GISAID Isolate EPI_ISL_74892
    . . . . . . . . 5 Polymorphisms (2 Amino and 3 Silent)
    . . . . . . . . #2I [Emergent H7N9],
    . . . . . . . . . . . [H5N1, H13],
    . . . . . . . . syn99I (ATa) [H7N7],
    . . . . . . . . . . . . . . . . . [avH1N1farm],
    . . . . . . . . syn228G (GGa),
    . . . . . . . . 302K,
    . . . . . . . . syn413K (AAg))

    . . . . ChinaHeilongjiangSaertuSWL174_C1_21M_2009_11_02 (
    . . . . . . . . GISAID HA EPI256402
    . . . . . . . . GISAID Isolate EPI_ISL_74633
    . . . . . . . . 2 Polymorphisms (0 Amino and 2 Silent)
    . . . . . . . . syn175E (GAg) [avH1N1],
    . . . . . . . . syn541C (TGt) [Emergent H7N9])

    . . . . ChinaHeilongjiangSWL1_E1_18M_2009_07_13 (
    . . . . . . . . GISAID HA EPI253374
    . . . . . . . . GISAID Isolate EPI_ISL_73577
    . . . . . . . . 4 Polymorphisms (3 Amino and 1 Silent)
    . . . . . . . . 5K mix wt [Emergent H7N9],
    . . . . . . . . . . . . . . . . . [H6N1, H9N2, H10N7],
    . . . . . . . . syn108L (cTG) [H5N1],
    . . . . . . . . . . . . . . . . . . [avH1N1farm],
    . . . . . . . . 208K [H7N9],
    . . . . . . . . . . . . [avH3N2],
    . . . . . . . . . . . . [avH1N1farm],
    . . . . . . . . 414I [H9N2],
    . . . . . . . . . . . . [avH3N2],
    . . . . . . . . . . . . [H6N1],
    . . . . . . . . . . . . [H13N2])


    NA Polymorphisms

    . . . . ChinaHeilongjiangLongshaSWL1181_C3_3M_2011_04_08 (
    . . . . . . . . GISAID NA EPI330848
    . . . . . . . . GISAID Isolate EPI_ISL_94652
    . . . . . . . . 9 Polymorphisms (3 Amino and 6 Silent)
    . . . . . . . . 44S,
    . . . . . . . . syn67V (GTc),
    . . . . . . . . syn217K (AAa),
    . . . . . . . . syn240T (ACc),
    . . . . . . . . 241I,
    . . . . . . . . syn360G (GGa),
    . . . . . . . . 369K,
    . . . . . . . . syn377P (CCa),
    . . . . . . . . syn378N (AAt))

    . . . . ChinaHeilongjiangXiangfangSWL1528_E2_2M_2011_03_04 (
    . . . . . . . . GISAID NA EPI330672
    . . . . . . . . GISAID Isolate EPI_ISL_94630
    . . . . . . . . 7 Polymorphisms (3 Amino and 4 Silent)
    . . . . . . . . 44S,
    . . . . . . . . syn168S (TCa),
    . . . . . . . . syn240T (ACc),
    . . . . . . . . 241I,
    . . . . . . . . 369K,
    . . . . . . . . syn377P (CCa),
    . . . . . . . . syn378N (AAt))

    . . . . ChinaHeilongjiangXiangyangSWL196_C2_3M_2011_03_03 (
    . . . . . . . . GISAID NA EPI330299
    . . . . . . . . GISAID Isolate EPI_ISL_94579
    . . . . . . . . 4 Polymorphisms (1 Amino and 3 Silent)
    . . . . . . . . 20V,
    . . . . . . . . syn238C (TGt),
    . . . . . . . . syn315G (GGg),
    . . . . . . . . syn446C (TGc))

    . . . . ChinaHeilongjiangXiangfang196_C2C1_2011_03_03 (
    . . . . . . . . GISAID NA EPI320019
    . . . . . . . . GISAID Isolate EPI_ISL_90926
    . . . . . . . . 5 Polymorphisms (1 Amino and 4 Silent)
    . . . . . . . . 20V,
    . . . . . . . . syn238C (TGt),
    . . . . . . . . syn315G (GGg),
    . . . . . . . . syn429G (GGa) mix wt,
    . . . . . . . . syn446C (TGc))

    . . . . ChinaHeilongjiangXiangfang191_E1E3_2011_01_08 (
    . . . . . . . . GISAID NA EPI325575
    . . . . . . . . GISAID Isolate EPI_ISL_93610
    . . . . . . . . 9 Polymorphisms (4 Amino and 5 Silent)
    . . . . . . . . 44S,
    . . . . . . . . syn171N (AAt),
    . . . . . . . . syn237S (TCc) mix wt,
    . . . . . . . . syn240T (ACc),
    . . . . . . . . 241I,
    . . . . . . . . 369K,
    . . . . . . . . syn377P (CCa),
    . . . . . . . . syn378N (AAt),
    . . . . . . . . 412Q mix wt)

    . . . . ChinaHeilongjiangLongshaSWL19_C4_27F_2010_01_13 (
    . . . . . . . . GISAID NA EPI258043
    . . . . . . . . GISAID Isolate EPI_ISL_75039
    . . . . . . . . 4 Polymorphisms (1 Amino and 3 Silent)
    . . . . . . . . 48K,
    . . . . . . . . syn247S (AGc),
    . . . . . . . . syn350S (TCg),
    . . . . . . . . syn372E (GAa))

    . . . . ChinaHeilongjiangJianhuaSWL18_C4_11M_2010_01_09 (
    . . . . . . . . GISAID NA EPI258039
    . . . . . . . . GISAID Isolate EPI_ISL_75038
    . . . . . . . . 6 Polymorphisms (1 Amino and 5 Silent)
    . . . . . . . . syn50N (AAc),
    . . . . . . . . 74I [Emergent H7N9],
    . . . . . . . . syn205V (GTa),
    . . . . . . . . syn315G (GGg),
    . . . . . . . . syn443I (ATc),
    . . . . . . . . syn446C (TGc))

    . . . . ChinaHeilongjiangXiangfangSWL1970_C2_20F_2009_12_3 0 (
    . . . . . . . . GISAID NA EPI257579
    . . . . . . . . GISAID Isolate EPI_ISL_74923
    . . . . . . . . 6 Polymorphisms (0 Amino and 6 Silent)
    . . . . . . . . syn41G (GGa),
    . . . . . . . . syn71N (AAt),
    . . . . . . . . syn125S (TCt),
    . . . . . . . . syn315G (GGg),
    . . . . . . . . syn398E (GAa),
    . . . . . . . . syn411E (GAg))

    . . . . ChinaHeilongjiangLongshaSWL1424_C1_22F_2009_12_19 (
    . . . . . . . . GISAID NA EPI257583
    . . . . . . . . GISAID Isolate EPI_ISL_74924
    . . . . . . . . 2 Polymorphisms (1 Amino and 1 Silent)
    . . . . . . . . 269I,
    . . . . . . . . syn392D (GAc))

    . . . . ChinaHeilongjiangJianhuaSWL1574_C1_4F_2009_12_14 (
    . . . . . . . . GISAID NA EPI257455
    . . . . . . . . GISAID Isolate EPI_ISL_74892
    . . . . . . . . 4 Polymorphisms (0 Amino and 4 Silent)
    . . . . . . . . syn160S (AGt),
    . . . . . . . . syn299S (TCa),
    . . . . . . . . syn370G (GGc),
    . . . . . . . . syn407V (GTc))

    . . . . ChinaHeilongjiangSaertuSWL174_C1_21M_2009_11_02 (
    . . . . . . . . GISAID NA EPI256401
    . . . . . . . . GISAID Isolate EPI_ISL_74633
    . . . . . . . . 1 Polymorphisms (0 Amino and 1 Silent)
    . . . . . . . . syn345G (GGt))

    . . . . ChinaHeilongjiangSWL1_E1_18M_2009_07_13 (
    . . . . . . . . GISAID NA EPI253373
    . . . . . . . . GISAID Isolate EPI_ISL_73577
    . . . . . . . . 0 Polymorphisms (0 Amino and 0 Silent)

    H7N9 Influenza Hemagglutinin and Neuraminidase Segments elucidated at 2013-05-03-01_00_40_588800 by GeneWurx see.PolyDetector v0, Copyright 2007-2013

    We acknowledge the authors, originating and submitting laboratories of the sequences from GenBank & from GISAID?s EpiFlu? Database on which this research is based. An additional list is detailed in the linked PDF entitled "GISAID_Citations_H5N1_2011" at Is H7N9 Spreading from Human to Human in China? Post#164

    GISAID Citations

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