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WHO | Influenza at the Human-Animal Interface, monthly risk assessment summary, 3 October 2016, H9N2 6 cases 1 Fatal [Accessed 8-Oct-16] - 3 new cases

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  • WHO | Influenza at the Human-Animal Interface, monthly risk assessment summary, 3 October 2016, H9N2 6 cases 1 Fatal [Accessed 8-Oct-16] - 3 new cases

    WHO | Influenza at the Human-Animal Interface, monthly risk assessment summary, 3 October 2016 [Accessed 8-Oct-16]

    Avian influenza A(H9N2) viruses
    Current situation:


    Since the last update10, two laboratory-confirmed human cases of A(H9N2) virus infection were reported to WHO from China. No abnormalities were observed among close contacts of these cases at the time of reporting.
    In addition, four other cases were identified in China over the past six months, including one retrospectively diagnosed case from 2015. For more details on these cases, see Table 2 below.
    The outcome of a previously reported case, a 57-year-old woman with underlying conditions from Sichuan province in China, was recently reported as fatal. This would be the first fatality associated with influenza A(H9N2) virus infections in humans. Avian influenza A(H9N2) viruses are enzootic in poultry in China.
    Table 2: Information on additional human cases of avian influenza A(H9N2) identified in China
    Province or region reporting (province of assumed exposure, if different from reporting province or region) Age Sex Date of onset (yyyy/mm/dd) Case condition at time of reporting Exposure history

    1. Guangdong 29 F 2016/08/08 Recovered Poultry exposure [Previously Known]
    2. Yunnan 10 m M 2016/08/07 Recovered Poultry exposure [Previously Known]
    3. Guangdong 84 F 2015/02/04 Unknown Poultry exposure [Previously Known strain designation during this time states Male, meta details, this is a new case]
    4. Henan 5 F 2016/02/01 Unknown No poultry exposure [New]
    5. Guangdong 3 M 2016/07/09 Unknown Poultry exposure [New ]

    6. Jiangxi 4 F 2016/08/02 Unknown No poultry exposure [Previously Known]

    http://www.who.int/entity/influenza/.../en/index.html


    2015 Guangdong Male [No age] A/Zhongshan/201501/2015, China odd collection date 02-07-2015 C1 Male (No age] Y280B
    https://www.fludb.org/brc/fluSegment...ator=influenza


    Last edited by Biological100; October 10, 2016, 06:48 AM.

  • #2
    Blind spot:

    No details ever reported for this H9N2 case represented with A/Sichuan-Bazhou/1453/2014

    Antigenic and genetic characteristics of zoonotic influenza viruses and candidate vaccine viruses developed for potential use in human vaccines, 26 February 2015 [ 3 cases Egypt child (1); China (2) (Sichuan and Guangdong)

    Influenza A(H9N2)
    Influenza A(H9N2) viruses are enzootic in poultry populations in parts of Africa, Asia and the Middle East. The majority of viruses that have been sequenced belong to the A/quail/Hong Kong/G1/97 (G1), A/chicken/Beijing/1/94 (Y280/G9), or Eurasian clades. Since 1998, when the first human infection was detected, the isolation of A(H9N2) viruses from humans and swine has been reported infrequently. In all human cases the associated disease symptoms have been mild and there has been no evidence of human- to-human transmission.
    Influenza A(H9N2) activity from 24 September 2014 to 23 February 2015 Three human cases of A(H9N2) infection have been reported in this period with no fatalities. An infection of a child was reported in Egypt. Sequencing of the HA and NA genes confirmed presence of A(H9N2) virus RNA genetically related to the G1 lineage viruses circulating in poultry in Egypt. Investigations revealed that the case had a history of contact with apparently healthy backyard poultry. Two human cases of A(H9N2) were detected in Sichuan and Guangdong Provinces, China. The viruses were genetically related to Y280-like viruses detected during environmental sampling around the same time in the same and neighbouring provinces (Figure 3).
    2015 in 2014 Sichuan Bazhou District, Bazhong City, A/Sichuan-Bazhou/1453 2014

    http://www.who.int/entity/influenza/...pdate.pdf?ua=1

    Also their are 2 other H9N2 strain designations [IRD 19 available publically] with odd collection dates and an additional case never reported by WHO from Anhui, Chaozhou.

    I have 38 H9N2 mastered cases with missing details of 2 cases respectively.

    Comment


    • #3
      Originally posted by Biological100 View Post
      2015 Guangdong Male [No age] A/Zhongshan/201501/2015, China odd collection date 02-07-2015 C1 Male (No age] Y280B
      https://www.fludb.org/brc/fluSegment...ator=influenza
      I am going to add this case to the list for 2015. No officially announced case comes close to the collection date.

      Comment


      • #4
        It appears this case is not yet confirmed by WHO:

        China - Female, 4, serious condition, Guangdong province confirmation June 19, 2016 link


        Please see:

        FluTrackers Global Cumulative H9N2 Partial Case List 1998 - 2016 link

        Comment


        • #5
          Alright I'll post H9N2 list without hyperlinks upon request

          H9N2 Case 1 1998 Guangdong 14/12M Acute respiratory infection, live chickens in dwelling AShaoguan 402-98 CD 19-Aug-98

          H9N2 Case 2 1998 Guangdong 75M Acute respiratory infection, lives near farmer?s market Ashaoguan408-98, CD 19-Aug-98

          H9N2 Case 3 1998 Guangdong 4M Acute respiratory infection Exposure Unknown AShantou 217-98 CD 25-Jul-98

          H9N2 Case 4 1998 Guangdong 1F Acute respiratory infection Exposure Unknown AShantou 239-98 CD 5-Aug-98

          H9N2 Case 5 1998 Guangdong 36F Acute respiratory infection, Exposure to live poultry AShantou 252-98 CD 12-Aug-98

          H9N2 Case 6 1999 Hong Kong, Kowloon, 4F, 28-Feb-99, Hospitalised 1-Mar-99, RD 8-Mar-99; AHong Kong 1073-99 (G1-lineage)

          H9N2 Case 7 1999 Hong Kong, Hong Kong Island, 1F or 13-Months F, Onset 4-Mar-99, Hospitalised 5-Mar-99, RD-7-Mar-99; AHong Kong 1074-99

          H9N2 Case 8 1999 Guangdong 22-Months F Fever (38?C), cough No exposure to poultry, AGuangzhou 333-99 (BJ 94 lineage)

          H9N2 Case 9 2003 Hong Kong, Kwun Tong sub-district, Kowloon District , 5M Onset 25-Nov-03 Hospt 27-Nov-03 United Christian Hospital Discharged 29-Nov-03, AHong Kong210803

          H9N2 Case 10 2007 Hong Kong, Tseung Kwan O, Sai Kung District, 9-Month F onset 4-Mar-07 Hosp- 6-Mar-07 , Discharged 9-Mar-07 Mild upper respiratory infection [ strain] unknown exposure Hau Tak Estate Market

          H9N2 Case 11 2008 Hong Kong ex Shenzhen Guangdong SAR [2 months Female ] Onset 20-Dec-08, Hosp 22-Dec-08, Discharged 23-Dec-08 readmitted 29-Dec-8 suspected acute Leukaemia

          H9N2 Case 12 2009 Hong Kong ex Guangdong Province 47F [Hx UMC] Onset 26-Oct-09 Hospitalisation 28-Oct-09 St AHong Kong339822009 [47F] 29-Oct-2009 collection date Nasopharyngeal aspirate G1_Asia [PB2- D701N NS1-D92E]

          H9N2 Case 13 2009 Hong Kong, Sha Tin, x Nanshan District Shahe Village Whitehead [7th] 35 months F Chen onset end of end of November 2009, admitted to Prince of Wales Hospital, 11-Dec-09 discharged AHong Kong358202009

          H9N2 Case 14 2011 Bangladesh 51Month F Onset 25-Feb-11, Recovered 28-Feb-11, close contact with poultry, including sick quails [and dead sparrow on veranda 5 days before onset]

          H9N2 Case 15 2013 Hunan Yongzhou Lengshuitan District, Meiwan community, 7M Zhou Onset 19-Nov-13, outpt 20- to 22 Fever , recovered as 24-Nov-13 close contact with poultry ALengshuitan111972013

          H9N2 Case 16 2013 Hong Kong ex Shenzhen, Guangdong province [living in Luohu Huangbeiling] 86M Onset 28-Dec-13 , Hosp 28-Dec-13, stable as of 30-Dec-13 No clear history of exposure; AHong Kong3082014 [Candidate vaccine viruses]

          H9N2 Case 17 2015 in 2014 Sichuan Bazhou District, Bazhong City ASichuan-Bazhou1453 2014 [WHO]

          PENDING #18 another strain designation AGuangdong017472014 [WHO]

          H9N2 Case 18 2015 Guangdong Male [No age] AZhongshan2015012015, China odd collection date 02072015 C1 Male (No age] Y280B [NCBI/IRD/Swiss Bioinformatics]

          H9N2 Case 19 2015 199964 Egypt Aswan 3M Onset 15-Jan-15 Hosp 16-Jan-15 exposure poultry , confirmed 2-Feb-15 [Taiwan CDC]

          H9N2 Case 20 2015 Egypt Cairo 7F onset unknown Hospitalisation No, Co infection Inf B and H9N2, exposure to poultry [Promed]

          H9N2 Case 21 2015 Bangladesh 3.5-year-old F Onset 1-Feb-15 recovered 7-Feb-15 close contact with poultry, including sick quails, prior to her onset of illness [2nd in Bangladesh] ABangladesh3539262015

          H9N2 Case 22 2015 Egypt Cairo 9 Months F onset unknown Mild illness recovered at home, likely exposure to an environment contaminated with poultry waste

          H9N2 Case 23 2015 China Anhui Hefei Moumou 4F 14 April 2015 cured 16-Apr-15 Live animal market mild disease and none were hospitalised live poultry market exposure [He Jun et al. 2016 AAnhui333292015(H9N2)]

          H9N2 Case 24 2015 China Hunan 2M 1 Sept 2015 Unknown mild disease and none were hospitalised

          H9N2 Case 25 2015 Missing Case - Anhui Chuzhou Tao Moumou, male, 6 years old, students; Onset-September 6, 2015 Cured September 7 [He Jun et al. 2016 AAnhui4322692015(H9N2)]

          H9N2 Case 26 2015 China Hunan 15F Onset 15 Sept 2015 No known exposure mild disease and none were hospitalised

          H9N2 Case 27 2015 China Hunan 1F Onset 27 Oct 2015 Unknown mild disease and none were hospitalised

          H9N2 Case 28 2016 209864 2016 No # Bangladesh 46M poultry worker Onset 27-Oct-16 handling sick poultry recovered [3rd in Bangladesh] close contact with poultry, including sick quails

          H9N2 Case 29 2016 211296 28th Sichuan 57F Onset unknown- Hospitalised 9-Feb-16 UMC 16-Feb-16 Confirmed [Fatal WHO reported on in HAI 3-Oct-16]

          H9N2 Case 30 2016 211990 18 months Male Cairo Minshat Nasir Onset 10-Apr-16, Confirmed 20-Apr-16 good condition, Exposure Live poultry market, 2nd co infection Flu B [WHO]

          H9N2 Case 31 2016 213316 Xingning City, Meizhou City, Guangdong Luo 4F Onset 10-Jun-16, 12-Jun-16 SerC, poultry contact

          H9N2 Case 32 Hunan AHunan445572015 b Odd Collection date 30-Nov-15 Male Thraot swab unknown strain designation (No age] Y280B [NCBI/IRD/Swiss Bioinformatics]

          H9N2 Case 33 216283 Pingxiang City, Jiangxi , Ouyang 4 F Onset 2-Aug-16 recovered No poultry exposure

          H9N2 Case 34 215857 Southern District, Zhongshan City, Guangdong 29F hospitalised recovering onset 8-Aug-15, Confirmed and ADMITTED 19-Aug-16 discharged 19-Aug-16? respectively

          H9N2 Case 35 215999 Mengzi City, Honghe, Yunnan H9N2 10 month old Male cured Onset 7-Aug-16, Hosp 8-Aug-16, Discharged 16-Aug-16 [MSAR] Poultry exposure

          H9N2 Case 36 Guangdong 84 F 4-Feb-15 Unknown Poultry exposure [WHO reported 3-Oct-16] NOT/Possible Male variance AZhongshan2015012015 see case #18

          H9N2 Case 37 Henan 5 F Onset1-Feb-16 Unknown condition No poultry exposure [WHO reported 3-Oct-16]

          H9N2 Case 38 Guangdong 3M onset 9-Jul-16 Unknown condition, poultry exposure [WHO reported 3-Oct-16]


          I have many other details and references for these cases but this will give a good idea of the tip of the iceberg of Human H9N2 reported cases....

          Case 25 never reported by WHO [not on flu trackers but you have the journal article]
          Last edited by Biological100; October 10, 2016, 10:34 AM.

          Comment


          • #6
            I added the journal article case to the list earlier today.

            Comment

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