China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

[sharon sanders]

Re: China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

At GISAID:

Isolate name: A/Guangdong-Shenzhen/1/2011(H5N1)
Isolate ID: EPI_ISL_100272
Passage: E1
Type: A / H5N1
Collection date: 2011-12-28
Host: Human
Location: Shenzhen City, China / Guangdong Province
Patient age: 39 Year(s)
Patient status: Deceased
Originating lab: WHO Chinese National Influenza Center - Beijing
Submission date: 2012-01-04
No Notes

[sharon sanders]

Re: China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

hat tip Francoise Ramona -

WHO Confirmation:

Avian influenza - situation in China - update 6

5 JANUARY 2012 - The Ministry of Health of China has notified WHO of a human case of avian influenza A (H5N1) virus infection.

The case is a 39-year-old male from Shenzhen, Guangdong Province. He developed symptoms on 21 December 2011 and was admitted to hospital on 25 December 2011. He was in critical condition and died on 31 December 2011. The case was laboratory diagnosed by Guangdong CDC on 30 December 2011 and confirmed by China CDC on 31 December 2011. Investigation into the source of infection is ongoing. Close contacts of the case are being monitored and to date all remain well.

Of the 41 cases confirmed to date in China, 27 have been fatal.

http://www.who.int/csr/don/2012_01_05b/en/index.html

[JimO]

Re: China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

http://www.theepochtimes.com/n2/china-news/chinese-bird-flu-death-was-mutant-strain-say-health-experts-168753.html

Chinese Bird Flu Death Was Mutant Strain, Say Health Experts
First bird flu death confirmed in China since 2010
By Jane Lin
Epoch Times Staff

The strain of H5N1 avian influenza that infected and killed a man in Shenzhen, China, was a mutant strain of the deadly virus, according to Chinese and Hong Kong media reports.

A 39-year-old bus-driver named Chen died from multiple organ failure on Dec. 31 after being infected, according to the Department of Health of Guangdong Province.

The health department stated that an expert team had examined Chen and confirmed that he contracted the H5N1 avian influenza virus.

Later, experts from both Shenzhen and Hong Kong confirmed that it was a mutant strain of H5N1, though they did not go into detail about what kind of mutation it was.

The Guangdong Department of Health said that in the month before Chen became infected he did not have a history of contact with domestic fowl, nor had he traveled away from home. Further, the 120 people who were confirmed to have had close contact with him did not show any symptoms of the disease.

Ma Wuhan, Deputy Director of the Center for Disease and Control in Shenzhen, told Hong Kong media that the form of the virus that infected the patient was “very virulent,” which is why the patient had experienced a strong reaction, ending in death. He also said that so far, the virus has not been transmitted from human to human: only from animal to human.

Chinese media reported that Chen lived close to a man-made lake and wetlands inhabited by many wild birds. An expert team on avian influenza also stated in the diagnostic report that “the patient had a habit of working out in the morning, and had contracted the disease during the bird flu season.”

Zhou Poping, the chief of an avian influenza expert team in Shenzhen, said that although the patient did not have contact with fowl, experts surmised that he contracted the virus through bird feces, according to a report by Nanfang Daily.

In Hong Kong, the nearby island city south of Shenzhen, there were three reported cases on Dec. 20 of bird and chicken deaths due to the H5N1 virus.

This is the first reported human death due to the bird flu virus in China in 18 months. In June 2010 in Hubei Province, a pregnant woman died from the virus, according to reports.

[Giuseppe]

Re: China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

[Source: European Centre for Disease Prevention and Control (ECDC), full PDF document: (LINK). Edited.]


RAPID RISK ASSESSMENT


Human fatality from highly pathogenic avian influenza A(H5N1) virus infection in Guangdong province, China


4 January 2012



Main conclusions and recommendations

China has reported a single case of highly pathogenic avian influenza A(H5N1) virus infection in Guangdong province.

This case is not part of a cluster.

The initial sequence analysis of the virus genome indicates that the virus is genetically closely related to influenza A(H5N1) viruses recently detected in wild birds in Hong Kong, and therefore it is more likely that the infection is of avian than human origin.

This new human case is not unexpected. In countries where avian influenza A(H5N1) virus is entrenched in bird populations and affecting poultry, sporadic infections are likely to continue to occur among exposed humans, occasionally resulting in small clusters of human cases.

The report of a single fatal human case in Guangdong province, China, does not change the current assessment of risk to human health in the EU or globally from wild-type A(H5N1). The risk is considered to be very low in EU/EEA countries. However, vigilance for avian influenza A(H5N1) and other animal influenza viruses in domestic and wild animals in Europe remains important.



Public health issue

A human fatality due to highly pathogenic avian influenza A(H5N1) virus infection in Guangdong province, China and whether this case is indicative of increased human-to-human transmission of wild-type A(H5N1) viruses.



Source of assessment request

Request from the European Commission, Directorate-General for Health and Consumers received on 3 January 2012.



Disease and other relevant background information

Please refer to the previous publications:

• Rapid Risk Assessment: Potential resurgence of highly pathogenic H5N1 avian influenza, September 2011, available from http://www.ecdc.europa.eu/en/publications/Publications/1109_TER_risk_assessment_H5N1_bird_flu_resurgence. pdf [1]
• ECDC Review: (Yet) another human A/H5N1 influenza case and cluster ? when should Europe be concerned? Eurosurveillance 2008; Volume 13, Issue 15, 10 April 2008 http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=18833 [2]
• ECDC Risk Assessment: The public health risk from highly pathogenic avian influenza viruses emerging in Europe with specific reference to type A/H5N1, version 1 June 2006 http://ecdc.europa.eu/en/publications/Publications/0606_TER_The_Public_Health_Risk_from_Highly_Pathog enic_Avian_Influenza_Viruses_Emerging_in_Europe.pd f [3]

Event background information

The Chinese health authorities have reported one fatality following infection with highly pathogenic avian influenza (HPAI) A(H5N1) virus.

The case is a 39-year-old male bus driver who lived and worked in the city of Shenzhen in southern China?s Guangdong province, immediately north of Hong Kong SAR. He developed symptoms on 21 December 2011, was admitted to the hospital four days later and died of multiple organ failure on 31 December [4,5]. He reportedly had no relevant travel history, nor known close contact with poultry or wild birds, environmental exposure or contact with infected persons prior to onset of symptoms.

The gene sequencing analysis has revealed that the influenza A(H5) virus detected in this case belongs to clade 2.3.2.1 and is very similar to those viruses from the wild birds recently detected in Hong Kong (A/Guangdong-Shenzhen/1/2011HA gene segment accession nr. EPI347304 and personal communication).

No avian influenza A(H5N1) virus infection outbreak in animals was reported in Guangdong province in 2011. In neighbouring Hong Kong SAR, where surveillance for A(H5N1) viruses is especially intense, one dead chicken and two dead wild birds were diagnosed with A(H5N1) virus infections in December 2011 [6].

This case is the first human case of HPAI A(H5N1) virus infection reported in China in 2011. Since 2003, China has reported 40 confirmed human cases resulting in 26 fatalities [7].



ECDC threat assessment for the EU

This case of HPAI A(H5N1) virus infection reported in China does not indicate a change in the risk for human-to-human transmission for the following reasons:

• It is a single isolated case, not part of a cluster.
• It occurred in a country where avian influenza is entrenched.
• No contact with sick patients has been reported.
• The identified clade suggests transmission from birds.

Conclusions

This new human case is not unexpected. In countries where avian influenza A(H5N1) viruses are entrenched in wild bird populations and are occasionally transmitted to domestic poultry, sporadic infections and even small clusters will probably continue to occur among humans who have contact with infected poultry or wild birds.

Human-to-human transmission cannot be completely ruled out even in this case but there is no evidence of human-to-human transmission here or elsewhere.

The recent report of a single human case of a wild-type influenza A(H5N1) virus infection in Shenzhen city, Guandong province, China, does not change the current assessment of the risk to human health in the EU or globally. The risk is considered to be very low in EU/EEA countries.

However, vigilance for avian influenza A(H5N1) in domestic poultry and wild birds and other animal influenza in Europe and elsewhere remains important.



Contact

support@ecdc.europa.eu



References

1. European Centre for Disease Prevention and Control. Rapid Risk Assessment: Potential resurgence of highly pathogenic H5N1 avian influenza, September 2011. Available from http://www.ecdc.europa.eu/en/publications/Publications/1109_TER_risk_assessment_H5N1_bird_flu_resurgence. pdf [Accessed on 03 January 2012]
2. Nicoll A. (Yet) another human A/H5N1 influenza case and cluster ? when should Europe be concerned?. Euro Surveill. 2008;13(15):pii=18833. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=18833 [Accessed on 03 January 2012]
3. European Centre for Disease Prevention and Control. The Public Health Risk from Highly Pathogenic Avian Influenza Viruses Emerging in Europe with Specific Reference to type A/H5N1. June 2006. Available from: http://ecdc.europa.eu/en/publications/Publications/0606_TER_The_Public_Health_Risk_from_Highly_Pathog enic_Avian_Influenza_Viruses_Emerging_in_Europe.pd f [Accessed on 03 January 2012]
4. Centre for Health Protection. The Government of the Hong Kong Special Administrative Region, Notification of a human case of H5N1 in Shenzhen. Press release, 30 December 2011. Available from: http://www.info.gov.hk/gia/general/201112/30/P201112300568.htm [Accessed on 03 January 2012]
5. Xinhua News Agency. Health authorities identify virus leading to Guangdong bird flu death, 02 January 2012. Available from: http://news.xinhuanet.com/english/china/2012-01/02/c_131339151.htm [Accessed on 03 January 2012]
6. World Organisation for Animal Health, World Animal Health Information Database (WAHID).Available at http://web.oie.int/wahis/public.php?page=home [Accessed on 03 January 2012]
7. World Health Organization. Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO, 2003-2011. 15 December 2011. Available from: http://www.who.int/influenza/human_animal_interface/EN_GIP_20111215CumulativeNumberH5N1cases.pdf [Accessed on 03 January 2012]

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[sharon sanders]

Re: China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

Report of no new suspected or confirmed H5N1 cases in Shenzhen. The observation of 120 contacts of Mr. Chen was lifted.

machine translation -


120 close contacts of avian influenza lifting observation
[22:29] 2012/01/06

East Shenzhen interactive An informed disease control department said that as of yesterday, no new suspected or confirmed in Shenzhen of human infection of highly pathogenic avian influenza reported, while 120 died with bird flu close for Shenzhen residents Chen Fayu contacts, the current lifted all medical observation.

Zhttp://news.on.cc/cnt/china/20120106/bkn-20120106222926784-0106_00922_001.html

[Treyfish]

Re: China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

..Since 2003, China has reported 40 confirmed human cases resulting in 26 fatalities .. Amazing is it not? Amazing..

Spread of avian influenza culprit: famous birds or poultry
at 08:26 on January 7

Things are not so terrible." When "China Science News" correspondent on 6 January by researchers with the Institute of Microbiology, Shenzhen about drivers who report a case of bird flu, researchers say it is dull.
In their eyes, every year people were killed in bird flu, no fuss, not to mention large-scale outbreaks.
However, as Shenzhen drivers are actually infected poultry or infected by migratory birds, may be a never shrouded in mystery.

Transmission of avian influenza is very strange. According to the associate researcher Liu Di Jieshao, outbreaks of avian flu since 2005, the Institute of Microbiology Chinese Academy of Sciences of the high-Fu group and the Northwest Plateau Institute of Biology Li Hing group, has begun to track migratory birds traces of bird flu has not stopped.
2012, at the beginning of the cold Qinghai-Tibet Plateau, migratory birds has not yet arrived, they temporarily can not obtain data fashion.
Task Force in 2005, an outbreak of avian flu, do migratory birds in Qinghai Lake to find a highly pathogenic virus H5N1, 2006 年 also isolated a lot. By 2007, the migratory birds at Qinghai Lake, the bird flu virus is relatively small, almost disappeared in 2008. However, in 2009 and 2010, another group of fish in the lake gulls, brown-headed gulls and cormorants and other H5N1 viruses isolated from migratory birds at a new branch Clade2.3.2...

http://tech.hexun.com/2012-01-07/137034216.html

[sharon sanders]

Re: China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

Evidently they did some "environmental" testing and got 5 "weakly" positive H5N1 results. Also, all 120 contacts were treated with oseltamivir. This may have affected their H5N1 negative test results.

machine translation -

120 cases of avian influenza in Shenzhen celebrity lifted observation of close contacts
<<Top News ArticlesYangcheng Evening News Luoyun Fang 2012-1-6

　　Reporters learned from Shenzhen disease control department, as of 5, no additional Shenzhen (suspected / confirmed) were infected with highly pathogenic avian influenza case reports, a total of 120 close contacts of all the lifting medical observation; cumulative detection outside the 31 environmental samples , of which five were of avian influenza H5N1 nucleic acid was weakly positive; Tightlock were detected six samples, were negative for avian influenza H5N1 nucleic acid.
　　December 30, 2011, the Guangdong Provincial Health Department confirmed Moumou suspected human infection of highly pathogenic avian influenza cases in 2011 China's first human infection of highly pathogenic avian influenza. CDC staff to track the first time in close contact with patients, to determine the 120 close contacts and their rosters of health education, give oseltamivir phosphate preventive medication; residence for patients to carry out terminal sterilization, so that eliminate possible sources of infection. Currently, 120 people to lift all medical observation.

Zhttp://news.39.net/jbyw/201216/1876752.html

[sharon sanders]

Re: China - Human case of H5N1 Dies in Shenzhen, Guangdong province (December 30 2011)

Still debating the cause of this fatal H5N1 illness has led to a warning about walking in the park.

machine translation -


snip

Recently, media reports said Merlin Hill Country Park, deserted, it was chicken duck pigs in the park to feed the dog, but also on-site slaughter to nearby residents sell. Their production, sewage everywhere emissions, destruction of park ecological environment. 　　Reporters yesterday to interview from the foot of the edge near the greenway has been to the hillside, you can see is full of makeshift shacks. Shacks surrounding the Li Zhilin, some enclosure chicken base stove a fire that outside dog groups, slightly gentle slopes of the shack next to the wasteland to grow vegetables, Hose lead to spring from the mountains, cook and clean for slaughter chicken kill a dog. The odor of livestock manure often floated into the kitchen in the nearby residents of the home across the park boundary, the stench harder and harder. Lead to large-scale spraying insecticide - aerosols like smoke fire　　at 14:50 on the February 9 Xu, Lotus Hill Park, the west side of the smoke billowing Park citizens have police, fire officers and men received reportedly drove, but found that it is a false alarm - the original park staff are spraying pesticides toward the trees. 　　To kill pests, the staff of the Lotus Hill Park toward the leaves with smoke machine spraying pesticide spray. Before the public can see the "smoke", is released from the machine, a large number of white mist. Site visitors come to understand, have suggested to the staff, said the park during similar operations before, with the fire department to say hello, good public information in order to avoid the tourists panic and fire wasteful employment of police. Encourage travel exercise - walking down the road may be infected with avian flu　　in Shenzhen Chen December 30, 2011, was diagnosed with suspected cases of H5N1 avian influenza, and died on December 31. This is Shenzhen, the first case of human infection with bird flu deaths. Mr. Chen illness did not come into contact with poultry, but the habit of exercising to the seaside Wetland Park. 　　CDC deputy director of Shenzhen City, the Mahan Wu said, epidemiological investigation, before the death of the patients with disease within one month without a clear history of poultry exposure, no history of going out. In this case of human infection with highly pathogenic avian influenza does not matter, and some time ago the bird flu occurred in Hong Kong before the onset of symptoms within one month without an exit. 　　"According to his wife, the one people usually do not like to eat birds," He Jianfeng, director of the Guangdong Provincial Center for Disease Epidemiology Institute, said the survey found that the onset of symptoms until the morning exercise habits, and often to the beach Wetland exercise So do not rule out that there will come into contact with sick birds. Reporters Wenfeng 　　: the Wenfeng source People)

Zhttp://roll.sohu.com/20120215/n334814983.shtml