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Canada - British Columbia health statement: First confirmed positive human case of H5N1 avian influenza detected in B.C. - November 9, 2024

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  • #16
    The Public Health Agency of Canada (PHAC) today confirmed a human case of avian influenza (also known as bird flu) caused by influenza A(H5N1) virus in Canada. This is the first domestically acquired human case of H5N1 avian influenza.

    On Saturday, November 9, the Office of the Provincial Health Officer for British Columbia reported that a teenager in British Columbia was hospitalized and tested presumptive positive for H5 avian influenza. Today, the Public Health Agency of Canada's National Microbiology Laboratory (NML) in Winnipeg confirmed that the individual has avian influenza H5N1 and the genomic sequencing result indicates that the virus is related to the avian influenza H5N1 viruses from the ongoing outbreak in poultry in British Columbia (Influenza A (H5N1), clade 2.3.4.4b, genotype D.1.1).

    British Columbia officials continue to undertake a thorough public health investigation and have taken important actions including contact tracing, testing and offering antiviral medication to contacts to prevent infection and to contain any potential virus spread. There have been no further cases identified at this time. The investigation has not yet determined how the individual became infected with avian influenza.

    The Public Health Agency of Canada is working closely with the Canadian Food Inspection Agency, provincial territorial, and local public health and animal health authorities, industry stakeholders and international partners on this response.

    Human infection with avian influenza A(H5N1) is rare and usually occurs after close contact with infected birds, other infected animals or highly contaminated environments. These investigations can be challenging and it is not always possible to identify the source of the infection. While there is an ongoing outbreak of avian influenza A(H5N1) in dairy cattle in the U.S., no cases of avian influenza have been reported in dairy cattle in Canada and there is no evidence of avian influenza in samples of milk in Canada. Milk and milk products that have been pasteurized are safe to consume. Furthermore, the clade of H5N1 avian influenza in dairy cattle in the U.S. is not the same as the clade confirmed in the domestically acquired human case in British Columbia.

    Based on current evidence, the risk of avian influenza infection for the general public remains low at this time. The risk of avian influenza infection is higher for those who have unprotected exposure to infected animals.

    PHAC, the Canadian Food Inspection Agency and our partners are actively monitoring and collaborating on the domestic and global avian influenza situation. We will continue to assess the risk that avian influenza poses in Canada based on new, emerging evidence.

    "Our thoughts are with this individual and their family, as well as the health workers who are engaged in their care at this difficult time. The Public Health Agency of Canada is working with our human and animal health partners to swiftly investigate and respond to this case", said Dr. Theresa Tam, Chief Public Health Officer of Canada. "This detection was picked up via hospital -based influenza surveillance, confirming that human influenza surveillance in British Columbia and Canada is effective at detecting avian influenza A(H5). We must continue to remain vigilant in our efforts to prevent the spread of avian influenza between animals and to humans."

    As a general precaution to prevent avian influenza infections, people should not handle live or dead wild birds or other wild animals, and should keep pets away from sick or dead animals. People who work with sick animals or in contaminated environments, such as farmers, should take precautions, including using personal protective measures to reduce the risk of getting or spreading avian influenza.

    If you think you may have been exposed to avian influenza, contact your health care provider and/or local public health authority for assessment and advice. Based on the assessment by your local public health authority, you may be asked to self-monitor for signs and symptoms of avian influenza for 10 days after your last exposure.


    Comment


    • #17
      Lab confirms Canada’s first case of avian flu infection in humans in B.C.


      Canada's Public Health Agency says the hospitalized teenager has the H5N1 avian flu, the same strain related to viruses found in B.C. flocks in an ongoing
      The Canadian Press
      Chuck Chiang
      Published Nov 13, 2024 • Last updated 50 minutes ago​

      The public health agency said it was notified by B.C. health authorities on Saturday that the teenager tested presumptive positive for the avian flu, and Tam said field epidemiologists are looking at potential sources for the teen’s exposure….



      ..The investigation “could take some time,” she said, because they haven’t been able to directly ask the teenager about where they might have become infected.



      “We are unable to speak to the patient because the patient is quite sick,” Tam said. “And so, I think some of the information is necessarily second-hand from the family members.



      “The good news is up to now, none of the close contacts like family members have tested positive.”…


      https://theprovince.com/news/bc-avia...tion-confirmed
      CSI:WORLD http://swineflumagazine.blogspot.com/

      treyfish2004@yahoo.com

      Comment


      • #18
        Originally posted by tetano View Post
        The Public Health Agency of Canada (PHAC) today confirmed a human case of avian influenza (also known as bird flu) caused by influenza A(H5N1) virus in Canada. This is the first domestically acquired human case of H5N1 avian influenza.

        On Saturday, November 9, the Office of the Provincial Health Officer for British Columbia reported that a teenager in British Columbia was hospitalized and tested presumptive positive for H5 avian influenza. Today, the Public Health Agency of Canada's National Microbiology Laboratory (NML) in Winnipeg confirmed that the individual has avian influenza H5N1 and the genomic sequencing result indicates that the virus is related to the avian influenza H5N1 viruses from the ongoing outbreak in poultry in British Columbia (Influenza A (H5N1), clade 2.3.4.4b, genotype D.1.1).
        ...

        Hat tip to Michael Coston

        HPAI Detections in BC
        ...
        Wildlife and Environmental Surveillance Weekly AIV Intelligence Update (Nov 13, 2024)
        ...
        Note that all HPAI detections in wild birds are associated with the HPAI strain D1.1. This is the same strain is being detected in BC poultry and is a descendant of the A3 strain that was circulating in wild birds and poultry in the fall of 2023.
        ...




        Comment


        • #19
          Bird flu: Canadian teenager is critically ill with new genotype

          BMJ 2024; 387 doi: https://doi.org/10.1136/bmj.q2529 (Published 14 November 2024)Cite this as: BMJ 2024;387:q2529​



          A Canadian adolescent is in a critical condition in a British Columbia hospital after becoming infected with a new genotype of H5N1 highly pathogenic avian influenza (HPAI).

          The patient, who has not been publicly identified, developed conjunctivitis on 2 November, followed by fever and coughing. While these symptoms have been common in people infected with H5N1 bird flu in North America—until now, all US cases—the teenager in Canada then developed acute respiratory distress syndrome and was admitted to intensive care on 8 November. The diagnosis of avian flu was confirmed, and the genotype identified, on 13 November.

          “This was a healthy teenager prior to this, so no underlying conditions,” said British Columbia’s health officer, Bonnie Henry, at a news conference. “It just reminds us that in young people this is a virus that can progress and cause quite severe illness, and the deterioration was quite rapid.”

          The patient has been treated with “multiple medications,” she said. The Public Health Agency of Canada has said that the virus is “related to the avian influenza H5N1 viruses from the ongoing outbreak in poultry in British Columbia (Influenza A (H5N1), clade 2.3.4.4b, genotype D1.1).”

          The teenager is the first person to be infected with H5N1 avian flu in Canada and the first person in North America to develop severe symptoms …

          View Full Text

          A Canadian adolescent is in a critical condition in a British Columbia hospital after becoming infected with a new genotype of H5N1 highly pathogenic avian influenza (HPAI). The patient, who has not been publicly identified, developed conjunctivitis on 2 November, followed by fever and coughing. While these symptoms have been common in people infected with H5N1 bird flu in North America—until now, all US cases—the teenager in Canada then developed acute respiratory distress syndrome and was admitted to intensive care on 8 November. The diagnosis of avian flu was confirmed, and the genotype identified, on 13 November. “This was a healthy teenager prior to this, so no underlying conditions,” said British Columbia’s health officer, Bonnie Henry, at a news conference. “It just reminds us that in young people this is a virus that can progress and cause quite severe illness, and the deterioration was quite rapid.” The patient has been treated with “multiple medications,” she said. The Public Health Agency of Canada has said that the virus is “related to the avian influenza H5N1 viruses from the ongoing outbreak in poultry in British Columbia (Influenza A (H5N1), clade 2.3.4.4b, genotype D1.1).” The teenager is the first person to be infected with H5N1 avian flu in Canada and the first person in North America to develop severe symptoms …
          CSI:WORLD http://swineflumagazine.blogspot.com/

          treyfish2004@yahoo.com

          Comment


          • #20
            Avian flu detected in Fraser Health not at any Langley schools

            Fraser Health sent a notice to superintendent after first human case

            Kyler Emerson
            26 minutes ago
            ...
            In a mass notice to school districts in the Lower Mainland, Fraser Health confirmed the positive human case of avian flu is not in the Langley School District.

            According to a letter ​sent to Langley superintendent Mal Gill, "there is no known exposure at any school" within Langley and that "there have been no further cases identified at this time."
            ...

            -------------------------------

            From the PDF link above:


            Office of the Chief Medical Health Officer
            Suite 400, Central City Tower
            Surrey, BC V3T 0H1
            604-587-7896
            November 12, 2024

            Dear Superintendent,

            Re: H5 Avian Influenza Communication

            As the Office of the Provincial Health Officer and the Ministry of Health shared on Saturday, November 9,
            a teenager from the Fraser Health region has tested presumptively positive for avian influenza caused by
            the H5 influenza virus. This is the first occurrence of avian influenza due to the H5 virus acquired by a
            person in B.C. and in Canada. Further testing is taking place to confirm the positive result by the National
            Microbiology Lab in Winnipeg.

            This is a rare event. There have been a small number of human cases in the U.S. and elsewhere. Public
            Health is following up with contacts who may have been exposed to assess for symptoms and provide
            guidance on testing and prevention measures. There have been no further cases identified at this time.
            There is no known exposure at any school. The source of exposure is very likely to be an animal or
            bird and is being investigated by B.C.’s Chief Veterinarian and Public Health teams. The investigation
            involves Public Health teams from Fraser Health, BC Centre for Disease Control (BCCDC), the BCCDC
            Public Health Laboratory, BC Children’s Hospital, the Office of the Provincial Health Officer, Office of the
            Chief Veterinarian, Ministry of Agriculture and Food, and others.

            Preventative measures

            We can protect ourselves and our communities against avian influenza.
            • Stay up to date on all immunizations, especially the seasonal flu vaccine.
            • Petting zoo and farm visits can continue but direct physical contact with all birds (including all poultry,
            ducks or any other waterfowl) should be avoided at this time.
            • Do not touch sick or dead animals or their droppings and do not bring sick wild animals into your home.
            • Keep pets away from sick or dead animals and their feces (poo).
            • Report dead or sick birds or animals.
            o For poultry or livestock, contact the Canadian Food Inspection Agency (CFIA) Animal Health
            office: Contact a Canadian Food Inspection Agency office by telephone - inspection.canada.ca
            o For pets, contact your veterinarian or call the BC Animal Health Centre: 1-800-661-9903
            o For wild birds, contact the B.C. Wild Bird Mortality Line: 1-866-431-2473
            o For wild mammals, contact the B.C. Wildlife Health Program: 1 (250) 751-7246.
            About avian influenza

            Avian influenza viruses occur naturally among wild aquatic birds and spread easily from bird to bird. While
            it mostly affects birds, it can affect other animals too. In B.C., H5N1 has been detected in wild birds, on
            poultry farms and among small wild mammals, including skunks and foxes. Influenza viruses are adaptable
            and can change when strains from humans or different animal species mix and exchange genetic
            information. Avian influenza could become more serious if the virus develops the ability to transmit from
            person to person, with potential for human-to-human transmission.

            If you have been exposed to sick or dead birds or animals where avian influenza has been detected, watch
            for symptoms of influenza-like illness (see link below for more details). If you get symptoms within 10 days
            after exposure to sick or dead animals, tell your health care provider that you have been in contact with
            sick animals and are concerned about avian influenza. This will help them give you appropriate advice on
            testing and treatment. Stay home and away from others while you have symptoms.

            Learn More:
            • BCCDC information on avian influenza: Avian Influenza (bccdc.ca)
            • Avian influenza: How can I protect myself?: Avian flu: How can I protect myself? (bccdc.ca)
            • HealthLinkBC information on avian influenza: Avian Influenza (Bird Flu) | HealthLink BC

            Immunizations

            Remember, all students should stay up to date with their immunizations:
            • All routine school-aged immunizations are free in British Columbia.
            • Families can check their immunization records at healthgateway.gov.bc.ca
            • If a record is missing immunizations that were received, families can submit the record to Public
            Health by visiting fraserhealth.ca/ImmunizationForm
            • If more immunizations are needed, families can visit fraserhealth.ca/GetImmunized to learn how to
            book an appointment.

            Your continued support in keeping our children and communities healthy is much appreciated.

            Thank you,

            Ingrid Tyler, MD, CCFP, MHSc, MEd, FRCPC
            Vice President, Population Health and Chief Medical Health Officer
            Fraser Health Authority​

            Comment


            • #21
              Canadian teen’s bird flu infection is not the version found in cows
              ...
              By Helen Branswell Nov. 13, 2024
              Senior Writer, Infectious Diseases

              A Canadian teenager who is in critical condition after contracting H5N1 bird flu was infected with a version of the virus that is different from the one circulating in dairy cattle in the United States, Canadian authorities announced Wednesday.

              The National Microbiology Laboratory in Winnipeg confirmed the infection was indeed caused by the H5N1 virus. But genetic sequencing showed that it is of a genotype that has been found in wild birds, not the version that has been circulating in dairy cattle in the U.S.
              ...
              The virus that infected the Canadian teenager was a 2.3.4.4b virus of the D1.1 genotype. This version of the virus, which is spread by wild birds, has caused poultry outbreaks in a variety of places, including recently in Washington state.
              ...
              During a press conference on Tuesday, Henry warned that while the search for the source of the infection continues, it’s possible it will never be known how the teenager contracted the virus. STAT asked if that was an attempt to be prudent or an effort to set expectations. “A bit of both,” Henry said.

              However, comparing the genetic sequence of the virus from the teenager to those of known H5N1 poultry outbreaks could point to further clues, she said. “I’m more confident today than I was yesterday that we might actually find the [source], but we may not.”
              ...
              A Canadian teen who is in critical condition after contracting H5N1 bird flu was infected with a version of the virus that is different from the one circulating in U.S. cattle.

              Comment


              • #22
                Source: https://www.statnews.com/2024/11/18/...omic-analysis/


                H5N1 bird flu virus in Canadian teenager displays mutations demonstrating virus’ risk
                The virus, which appears not to have spread to anyone else, underwent mutational changes virologists didn’t want to see
                By Helen Branswell
                Nov. 18, 2024
                Senior Writer, Infectious Diseases

                The genetic sequence of the H5N1 bird flu virus that infected a teenager in British Columbia shows that the virus had undergone mutational changes that would make it easier for that version of H5N1 to infect people, scientists who have studied the data say.

                There’s currently no evidence the teenager, who remains in critical condition in hospital, infected anyone else. If that’s the case, it is likely this mutated version of the virus would die out when the teen’s illness resolves. The source of the teen’s infection has not been determined, so it’s impossible to know for sure if the mutations were in the virus that infected him or her. But scientists think it is more likely that the mutations developed during the course of his or her infection.

                Still, the fact that the mutations occurred at all is a reminder that H5N1 is a dangerous virus for people, one that could potentially trigger a pandemic if it acquired the capacity to easily infect people, flu virologists say.​..

                Comment


                • #23
                  Source: https://vancouver.citynews.ca/2024/1...-flu-risk-low/

                  B.C. teen avian flu patient still in critical condition; epidemiologist says risk to public low
                  By Michelle Meiklejohn and Charles Brockman
                  Posted November 21, 2024 3:39 pm.

                  The B.C. Ministry of Health says a teenager who was infected with H5N1, or avian flu, is still in critical condition after nearly two weeks.
                  On Saturday, Nov. 9, authorities shared that a teenager in the Fraser Health region had tested positive for the virus, otherwise known as bird flu.​..

                  Comment


                  • #24
                    Avian flu in B.C.: Dr. Bonnie Henry to provide update on Canada's first human case
                    ...
                    Author of the article:Cheryl Chan
                    Published Nov 26, 2024

                    B.C. provincial health officer Dr. Bonnie Henry will provide an update today on the status of the teenager who was infected with H5N1 avian influenza.

                    Henry is holding a news conference at 11 a.m. PT. Tuesday.

                    In the most recent update earlier this month, Henry said the teen was in critical condition with respiratory issues in B.C. Children’s Hospital.
                    ...

                    Health officials have been unable to locate the source of the teen's exposure, despite exhausting contact tracing and tests. Read more.

                    Comment


                    • #25
                      H5N1 update from BC Provincial Health Officer, Dr. Bonnie Henry


                      ...
                      Click image for larger version

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                      Scheduled for Nov 26, 2024

                      /https://www.youtube.com/watch?v=JH76Mi-Wntg

                      Comment


                      • #26
                        Final update on human avian influenza case in B.C.

                        News Release


                        Victoria

                        Tuesday, November 26, 2024 11:15 AM

                        Media Contacts

                        Andy Watson

                        Director of Communications
                        Office of the Provincial Health Officer
                        236 475-3094Ministry of Health

                        Media Relations
                        250 952-1887
                        ...

                        An extensive, multi-agency public-health investigation into an avian influenza case involving a B.C. teenager has identified no additional cases nor evidence of human-to-human transmission.

                        The goals of the investigation were to identify any contacts who may have had exposure to the teenager, determine the source of exposure, and ensure that there was no risk of new infections from either the teenager or animal sources. The investigation also included testing of household pets, birds and other animals from nearby premises, and environmental (soil, water) testing.

                        To date, all tests on humans, animals and environmental samples related to this investigation have been negative for influenza H5. While it is reassuring that no further cases have been identified, officials have also not been able to definitively identify the source of the young person’s infection.

                        The investigation has determined the teenager was infected with the same strain of influenza H5N1 currently circulating in wild birds and poultry in B.C.(Clade 2.3.4.4b, Genotype D1.1). Advanced testing at the BC Centre for Disease Control (BCCDC) Public Health Laboratory determined the whole genome sequence of the virus most closely matches that of wild birds found in the Fraser Valley area in October and was not directly related to outbreaks at poultry farms in B.C.

                        “Our thoughts continue to be with this young person as they remain in critical condition, and their family,” said Dr. Bonnie Henry, B.C.’s provincial health officer. “I am confident in the extensive public health investigation that was led by the Fraser Health team in partnership with the BCCDC Public Health Laboratory, our partners at BC Children’s Hospital and the chief veterinary officer. Though we have not been able to determine definitively the source of exposure, we were able to rule out many potential risks and ensure there are no further cases related to this young person.”

                        While this was the first case of H5N1 in a person in B.C. and the first acquired in Canada, there have been a small number of human cases in the U.S. this year, including one reported in a child in California last week.

                        Health, animal and environmental partners across B.C. have also been working together and with the Canadian Food Inspection Agency and other national and U.S. partners to respond to the increased detections of H5N1 avian influenza in poultry farms and wild birds in the province since early October.

                        Prevention measures
                        To protect yourself against avian influenza, the following prevention measures are recommended:
                        • Stay up to date on all immunizations, especially the seasonal flu vaccine.
                        • Do not touch sick or dead animals or their droppings and do not bring sick wild animals into your home.
                        • Keep your pets away from sick or dead animals and their feces.
                        • Report dead or sick birds or animals.
                          • For poultry or livestock, contact the Canadian Food Inspection Agency (CFIA) Animal Health office: https://inspection.canada.ca/en/abou...fice-telephone
                          • For pets, contact your veterinarian or call the BC Animal Health Centre at 1 800 661-9903
                          • For wild birds, contact the BC Wild Bird Mortality Line: 1 866 431-2473
                          • For wild mammals, contact the BC Wildlife Health Program: 1 250 751-7246

                        If you have been exposed to sick or dead birds or animals or work on farm where avian influenza has been detected, watch for symptoms of influenza-like illness. If you get symptoms within 10 days after exposure to sick or dead animals, tell your health-care provider that you have been in contact with sick animals and are concerned about avian influenza. This will help them give you appropriate advice on testing and treatment. Stay home and away from others while you have symptoms.

                        About avian influenza
                        Avian influenza viruses occur naturally among wild aquatic birds and spread easily from bird to bird. Since 2022, there has been unprecedented global spread of avian influenza caused by the H5N1 virus. While it mostly affects birds, it can affect other animals too. In addition to cases reported in wild birds and poultry farms in North America, the virus has infected mammals including dairy cattle, foxes, skunks, marine mammals and more. There have also been isolated reports of H5N1 detections in goats and in a pig in the United States. There have also been reports of cases in humans, notably following exposure to infected animals.

                        In B.C., H5N1 has been detected in wild birds, on poultry farms and among small wild mammals, including skunks and foxes. Most cases have been reported during migration season when wild birds carrying the virus are in high numbers in B.C. Since the beginning of October 2024, at least 54 infected poultry premises have been identified in B.C., along with numerous wild birds testing positive.

                        In B.C. and Canada, there have been no cases reported in dairy cattle and no evidence of avian influenza in samples of milk.

                        Influenza viruses are adaptable and can change when strains from humans or different animal species mix and exchange genetic information. Avian influenza could become more serious if the virus develops the ability to transmit from person to person, with potential for human-to-human transmission.

                        Learn More:

                        Ministry of Agriculture and Food information on avian influenza: https://www2.gov.bc.ca/gov/content/i...n-influenza-ai

                        BC Centre for Disease Control information on avian influenza: http://www.bccdc.ca/health-info/dise...vian-influenza

                        Avian influenza: How can I protect myself? http://www.bccdc.ca/resource-gallery...ect_myself.pdf

                        HealthLinkBC information on avian influenza: https://www.healthlinkbc.ca/illnesse...vian-influenza

                        Public Health Agency of Canada information on avian influenza: https://www.canada.ca/en/public-heal...enza-h5n1.html

                        WorkSafeBC information on avian influenza: https://www.worksafebc.com/en/health...ypes/avian-flu


                        An extensive, multi-agency public-health investigation into an avian influenza case involving a B.C. teenager has identified no additional cases nor evidence of human-to-human transmission.

                        Comment


                        • #27
                          Influenza cases at seasonal levels ahead of holidays, but bird flu raising concerns
                          ...
                          Alanna Smith, Globe and Mail
                          about an hour ago
                          ...
                          “The recent evolution of bird flu is a real concern,” said Dr. Brinkman, who tracks the evolution of avian flu viruses. She said the D1.1 genotype of H5N1, which severely sickened a patient in Louisiana this week and a British Columbia teenager last month, and the unrelated discovery this year of bird flu in cows in the United States are cause for caution.
                          ...
                          The H5N1 virus has not yet been detected in Canadian cattle. Both the B.C. and Louisiana cases are believed to be connected to birds.
                          ...
                          The B.C. young person was in critical condition but their current status is unknown. The province declined to give an update on the teenager’s case on Thursday.

                          There is no evidence of sustained human-to-human transmission of avian flu and health officials across Canada have stressed that the risk to the general public remains low despite widespread infections detected in domestic and wild birds.

                          “But this is the first winter where we’re going to have seasonal flu mixing with that flu and we’re just not sure what’s going to happen,” said Dr. Brinkman. She said there is potential for a reassortment virus, which is created when two or more viruses mix with one another and create a new infective agent.
                          ...

                          Comment


                          • #28
                            Source: https://www.nejm.org/doi/full/10.1056/NEJMc2415890

                            Critical Illness in an Adolescent with Influenza A(H5N1) Virus Infection
                            Published December 31, 2024


                            To the Editor:
                            Highly pathogenic avian influenza A(H5N1) viruses are circulating among wild birds and poultry in British Columbia, Canada.1 These viruses are also recognized to cause illness in humans. Here, we report a case of critical illness caused by influenza A(H5N1) virus infection in British Columbia.
                            On November 4, 2024, a 13-year-old girl with a history of mild asthma and an elevated body-mass index (the weight in kilograms divided by the square of the height in meters) of greater than 35 presented to an emergency department in British Columbia with a 2-day history of conjunctivitis in both eyes and a 1-day history of fever. She was discharged home without treatment, but cough, vomiting, and diarrhea then developed, and she returned to the emergency department on November 7 in respiratory distress with hemodynamic instability. On November 8, she was transferred, while receiving bilevel positive airway pressure, to the pediatric intensive care unit at British Columbia Children’s Hospital with respiratory failure, pneumonia in the left lower lobe, acute kidney injury, thrombocytopenia, and leukopenia (Table S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org). A nasopharyngeal swab obtained at admission was positive for influenza A but negative for A(H1) and A(H3) by the BioFire Respiratory Panel 2.1 assay (BioFire Diagnostics). Reflex testing of the specimen with the Xpert Xpress CoV-2/Flu/RSV plus assay (Cepheid) revealed an influenza A cycle threshold (Ct) value of 27.1. This finding indicates a relatively high viral load for which subtyping would be expected; the lack of subtype identification suggested infection with a novel influenza A virus. Oseltamivir treatment was started on November 8 (Table S2), and the use of eye protection, N95 respirators, and other precautions against droplet, contact, and airborne transmission were implemented.​...

                            Comment


                            • #29
                              [from previous post, #28]

                              ...
                              The virus was typed as clade 2.3.4.4b, genotype D1.1,4 most closely related to viruses detected in wild birds in British Columbia around the same time (Fig. S2). Markers of adaptation to humans were detected in the tracheal-aspirate specimen collected on November 9: the E627K mutation was detected (52% allele frequency) in the polymerase basic 2 (PB2) gene product, and analysis of the H5 hemagglutinin (HA) gene yielded ambiguous calls in the codons for amino acid residues E186 (E190 according to H3 mature HA numbering) — 28% allele frequency for E186D — and Q222 (Q226 according to H3 mature HA numbering) — 35% allele frequency for Q222H. The mutations in the H5 HA gene have previously been shown to increase binding to α2-6–linked sialic acids, which act as receptors that facilitate viral entry into cells in the human respiratory tract and enable viral replication.5

                              Highly pathogenic avian influenza A(H5N1) virus infection acquired in North America can cause severe human illness. Evidence for changes to HA that may increase binding to human airway receptors is worrisome.​

                              Comment


                              • #30
                                B.C. teen with avian flu discharged after weeks in hospital

                                ​ Posted: January 9, 2025 4:28 PM​

                                B.C. Children's Hospital says a 13-year-old girl with avian flu was discharged Tuesday after weeks in hospital.
                                The patient was taken to a pediatric intensive care unit with respiratory failure and pneumonia on Nov. 8, and health officials said she tested positive for H5N1 a day later.

                                A recent medical journal chronicled the teen's hospitalization in Vancouver, which involved tracheal intubation and supplemental oxygen.
                                Her family says in a statement that the experience has been "life-changing" and that they are grateful to have their daughter home.
                                -snip-

                                The B.C. Centre for Disease Control said it was comparing the genetic features of the local teenager's avian flu case with that of a patient in Louisiana hospitalized with a severe case of avian flu who died earlier this month.

                                Clinical microbiologist Dr. Agatha Jassem, co-program head of the virology lab at the BCCDC Public Health Laboratory, says they want to understand how the viruses in the two cases are related to each other, as well as to viruses circulating in birds.

                                This will help to assess how easily it adapts and transmits between animals and humans. Both cases are related to viruses detected in wild birds and poultry. While there is no evidence of human-to-human infection in either, it's something experts are keeping an eye on.
                                Jassem says the U.S. patient shared one of the three genetic mutations identified in the Canadian case, which infectious disease specialists have said could make it easier for the virus to spread from person to person.
                                The lab is testing samples collected on different days with a variety of methods to determine how the mutations affect replication of the virus in human airways.​

                                Comment

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