Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
<DL class=columnistProfile>Thai-UK import deal for nasal medication
<DD>Writer: APIRADEE TREERUTKUARKUL <DD>Published: 11/08/2009 at 12:00 AM <DD>Newspaper section: News</DD></DL>Thai authorities will import second-line type-A (H1N1) flu medicine following the case of an infected patient who did not respond to doses of oseltamivir.
Laboratory tests at Ramathibodi Hospital confirmed the discovery of a mutant flu strain that was resistant to the medicine.
Government Pharmaceutical Organisation (GPO) managing director Witit Artavatkun said the organisation would sign the agreement today to import zanamivir, the second-line anti-flu regimen, from Britain-based GlaxoSmithKline for use at state hospitals and for medicinal stockpiling to fight the flu pandemic.
"The British company has agreed to halve the price of the medicine," Dr Witit said.
Under the agreement, the price of zanamivir would be cut to 450 baht a dose.
The imported medicine will be distributed to state hospitals nationwide as a back-up for flu pandemic preparedness, he said.
Dr Witit said the GPO planned to import 30,000 doses as part of tomorrow's agreement.
As well as 50 million tablets of oseltamivir, Thailand has stockpiled 20,000 doses of zanamivir intranasal spray. The government has approved the Public Health Ministry's proposal to buy a further 20,000 more doses for stockpiling, bringing the total to 70,000. Dr Witit expressed concern over reports of the oseltamivir-resistant virus discovery because the drug resistance could affect the GPO's plan to produce the local first-line drug GPO-A-Flu.
Virologist Prasert Thongcharoen, chairman of the subcommittee responsible for academic and strategic planning against the flu pandemic, said the public should not panic about the reported drug resistance case.
"If we want to fight against invisible diseases, we should have sufficient weapons just like having both knives and guns," he said.
"Stockpiling the anti-flu drugs for 10% of the population is not even considered high."
Dr Prasert said the viral resistance case needed further tests to confirm whether the virus was resistant to oseltamivir.
The case was proved only by a sequencing test designed to monitor a residue of neuraminidase protein in H1N1 virus sample.
However, it is essential to test the virus resistance on the specific drug to confirm the resistance, he said.
In Thailand, only laboratories at Siriraj Hospital and the Department of Medical Sciences could conduct such a test.
Only Denmark, Hong Kong, Canada and Japan have reported oseltamivir-resistance cases, according to the World Health Organisation.
The members of the subcommittee from medical schools are drafting regulations and guidelines for using each anti-flu regimen for treatment to avoid the problem of drug resistance, Dr Prasert said.
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
The above translation confirms that H274Y is being indentified in H1N1 by a routine screening test, which is specific for the genetic change that encodes H274Y. However, it still remains unclear if this change was found in one swine flu patient with H274Y or if the one was in reference to one type of H1N1 (swine).
The original story said two patients, one infected with seasonal H1N1 and one infected with swine H1N1. However, H274Y is at or near 100% in Brisbane/59, which would be the strain of most seasonal flu. Thus, if a number of seasonal flu isolates were screened, there would be many examples of H274Y. Thus, the "one" may be in reference to the type of H1N1 and the story may have actually said the H274Y was found in two types of H1N1, seasonal H1N1 and swine H1N1.
Of course if "one" was in reference to the type of H1N1, then the actual number of swine H1N1 Thai isolates identified with H274Y may be significantly higher than one.Leave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
At 17:00 pm Aug. 10 date at the Department of Disease Control. Chairman of heavenly gold S.n.p. grow Academic Advisory Committee and the medical and public health strategy. Following the meeting the Sub 4 hour long meeting to consider the case found that patients with flu strains. A disease of the first resist drug, Wed Ramathibodi Information from the hospital reported that Samples of the virus in these patients. Ways to resist drug testing. View the location of the genetic sequence. If changes are made to test position 274 means that the virus often resist drug. In Thailand, a laboratory method to check resist drug has only 5 of the Department of Medical Sciences, Siriraj R.p. R.p. R.p. Chulalongkorn Rama's Institute of Medical Sciences and Military
S.n.p. sublime said. Also check the disease must be repeated. The antiviral drug testing with other species, which must be coordinated directly with the manufacturer of products directly. To deliver antiviral drugs to check the pure species. In Thailand, a laboratory test that is only 2 of the Science Department. และร.พ. Siriraj. If a laboratory to detect any virus resist drug. Will need to send blood samples to the laboratory immediately.
"In case of patients with Rama that resist drug. Verify the location of a genetic. The amino acids changes at positions 274, but not the actual features of genetic duplicate. Because all virus samples. And washing of history that These patients never received antiviral drug โอ cells not ทา Elsevier. So it is only found in patients suspected virus โอ cells resist drug Elsevier ทา not natural. Not to report the World Health Organization. Resist drug that occurred in Thailand "S.n.p. sublime.
In the February text scholar, director of forensic close Pharmaceutical Organization (Ap.) said that infectious influenza strains. โอ cells not resist drug ทา Elsevier in Thailand Affect the management of drug โอ cells not ทา Elsevier future. Now that the pharmacist is Tiai between drug production โอ cells Elsevier ทา not to grant 50 million provided for the sick. May have to wait. However, the case found that the cells resist drug โอ Elsevier ทา not only Case 1 does not need to stop drug production โอ cells not ทา Elsevier. Known as a resist drug found infected in the laboratory. The treatment of patients, and then disappeared. Combined with drug โอ cells Elsevier ทา not last for a long 4 years of material stored long 3 years and 7 years, it is not likely to be a problem in manufacturing.
Same day Tier.p. Bumruang Rajd Journalists reported After Khunying Ratns older daughter รา gene belongs former minister of Public Health To cure the flu strains. Today, the doctors allowed to return home. After symptoms improved. But also have Ratns lady lady must languish and prevent oral disease drugs.
Khunying Ratns daughter said. Government should protect and measures should not let the disease spread to another. Because during this rainy season to start. People may begin to be sick and ill flu. The body will be unhealthy and vulnerable to infections easily. In addition, if the spread of disease. May cause such a disease and will harden to resist drug control. The consequences could cause the disease to spread in the second round. So the government should push this agenda is the National Migration is not only interested in the appointment of police
http://www.khaosod.co.th/view_news.p...MHdPQzB4TVE9PQ==Leave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
<a rel="nofollow" href="http://www.recombinomics.com/News/08091001/H274Y_Toll.html">Commentary</a>Leave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
Mr. respectful person mentioned case Ramathibodi Hospital found that infected cells resist drug โอ not ทา Elsevier patients in 2009 that a new influenza strains by random inspection of the Department of Medical Science No disease resist drug. But when found in the laboratory. Ramathibodi Hospital on Aug. 8 will bring all information to the Academic Advisory Committee Meeting and the medical and public health strategy. Influenza type A, 1 g 1 a ligament Fri Fame Dr. golden golden civilization as president scholars together to consider that Resist drug found in blood Labs Rama's Hospital is the volume? Approach to treatment? And determined that not require a backup drug ซานา Elsevier. A drug to prevent or resist drug added.
http://search.sanook.com/news/admin_...OFQyMDowODowMQ==Leave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
Dr. Niman,
Do you have a link(s) to the news report(s) about possible H1N1 resistance to Tamiflu treatment in India?Leave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
Did anyone see this news story on H1N1 cases showing possible resistance to Tamiflu treatment in Vietnam from Thursday July 30th?
http://www.asianewsnet.net/news.php?sec=14&id=7090Leave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
No, I saw those reports as well as a similar report from India, but have not seen any confirmations (isolation of the H1N1 with H274Y).Originally posted by bcgauspohl View PostDr. Niman,
I've been reading your commentaries and posts about H1N1 developing Tamiflu resistance in more and more locations around the globe. My question is have you heard anything about H1N1 resistant cases popping up in Vietnam? Has anyone on this site heard of H1N1 resistance showing up in Vietnam? I ask because I saw a news story a few days back about it but I haven't heard anything since. I don't know if these H1N1 resistant cases were officially confirmed by the Vietnamese government. This is the news article published on Thursday July 30th:
Vietnamese H1N1 flu shows sign of resistance to treatments
VietNam News
Publication Date: 30-07-2009
At least four A /H1N1 flu patients had not responded normally to treatment at the HCM City Tropical Diseases Hospital, its deputy director said on Monday.
Two of the cases might be drug resistant, said Dr Tran Tinh Hien.
The announcement by Hien came as the city stepped up preparations to fight the spread of the flu, assigning more facilities and manpower as the number of patients testing positive for the virus increased sharply in recent days.
Health officials have warned that up to 2 million people could be infected by the virus as the epidemic spreads.
Dr Phan Van Nghiem, head of the HCM City Department of Health?s Medical Profession Division, said the municipal administration had allocated VND6 billion for the purchase of facilities like ambulances, respiratory aids and masks for city hospital staff.
All hospitals in the city were now allowed to receive and treat A/H1N1 flu patients and an additional 300 beds hadbeen prepared at district-level hospitals, health officials said during a meeting of health officials and the city?s Committee for Epidemic Prevention on Monday.
Besides the hospital facilities, medicines to treat the flu were also a major issue mentioned by doctors.
With the predicted number of patients, the city needs around 20 million tablets of Tamiflu, while it currently has just 13,000 in stock.
The Ministry of Health would be asked to assist the city in getting more tablets. A city health department official said it had requested the ministry for an immediate addition of 30,000 Tamiflu tablets.
Truong Quoc Cuong, head of the Viet Nam Drug Administration, said the country had enough materials to produce 10 million Tamiflu tablets. If necessary, more medicines as well as materials would be imported, he said.
Meanwhile, director of the Ha Noi Health Department Le Anh Tuan said that the city had prepared an A/H1N1 prevention plan.
Four sub-committees have been formed based on the scenario that health staff, medical facilities and drugs were reserved to provide treatment for 2,000 patients. All hospitals have reserved special isolation and treatment areas and have strengthened communication, and examination and monitoring for the disease.
The municipal health department also requested all State offices and schools to inform the local health sector or to call the department hotline if a case of A/H1N1 occurs. The health sector will send staff to localise and isolate patients, and monitor the disease area.
According to the department?s statistics, as of Tuesday there were 47 A/H1N1 cases in the city. Thirty-one had been discharged from the hospital and 16 were being treated at the National Institute of Infectious and Tropical Diseases.
The Hai Phong Health Department Tuesday also reported the first A/H1N1 flu cluster in the city when five members of one family were found positive with the virus in Kenh Duong Ward, Le Chan District.
The Ministry of Health reported 31 new A/H1N1 cases, bringing the nation?s total to 703 cases and still no fatalities.
bcgauspohlLeave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
Welcome bcgauspohl!Leave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
Dr. Niman,
I've been reading your commentaries and posts about H1N1 developing Tamiflu resistance in more and more locations around the globe. My question is have you heard anything about H1N1 resistant cases popping up in Vietnam? Has anyone on this site heard of H1N1 resistance showing up in Vietnam? I ask because I saw a news story a few days back about it but I haven't heard anything since. I don't know if these H1N1 resistant cases were officially confirmed by the Vietnamese government. This is the news article published on Thursday July 30th:
Vietnamese H1N1 flu shows sign of resistance to treatments
VietNam News
Publication Date: 30-07-2009
At least four A /H1N1 flu patients had not responded normally to treatment at the HCM City Tropical Diseases Hospital, its deputy director said on Monday.
Two of the cases might be drug resistant, said Dr Tran Tinh Hien.
The announcement by Hien came as the city stepped up preparations to fight the spread of the flu, assigning more facilities and manpower as the number of patients testing positive for the virus increased sharply in recent days.
Health officials have warned that up to 2 million people could be infected by the virus as the epidemic spreads.
Dr Phan Van Nghiem, head of the HCM City Department of Health?s Medical Profession Division, said the municipal administration had allocated VND6 billion for the purchase of facilities like ambulances, respiratory aids and masks for city hospital staff.
All hospitals in the city were now allowed to receive and treat A/H1N1 flu patients and an additional 300 beds hadbeen prepared at district-level hospitals, health officials said during a meeting of health officials and the city?s Committee for Epidemic Prevention on Monday.
Besides the hospital facilities, medicines to treat the flu were also a major issue mentioned by doctors.
With the predicted number of patients, the city needs around 20 million tablets of Tamiflu, while it currently has just 13,000 in stock.
The Ministry of Health would be asked to assist the city in getting more tablets. A city health department official said it had requested the ministry for an immediate addition of 30,000 Tamiflu tablets.
Truong Quoc Cuong, head of the Viet Nam Drug Administration, said the country had enough materials to produce 10 million Tamiflu tablets. If necessary, more medicines as well as materials would be imported, he said.
Meanwhile, director of the Ha Noi Health Department Le Anh Tuan said that the city had prepared an A/H1N1 prevention plan.
Four sub-committees have been formed based on the scenario that health staff, medical facilities and drugs were reserved to provide treatment for 2,000 patients. All hospitals have reserved special isolation and treatment areas and have strengthened communication, and examination and monitoring for the disease.
The municipal health department also requested all State offices and schools to inform the local health sector or to call the department hotline if a case of A/H1N1 occurs. The health sector will send staff to localise and isolate patients, and monitor the disease area.
According to the department?s statistics, as of Tuesday there were 47 A/H1N1 cases in the city. Thirty-one had been discharged from the hospital and 16 were being treated at the National Institute of Infectious and Tropical Diseases.
The Hai Phong Health Department Tuesday also reported the first A/H1N1 flu cluster in the city when five members of one family were found positive with the virus in Kenh Duong Ward, Le Chan District.
The Ministry of Health reported 31 new A/H1N1 cases, bringing the nation?s total to 703 cases and still no fatalities.
bcgauspohlLeave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
Director Medical Department "anti-virus to resist drug until symptoms are less. And no transmission to resist drug who experience a close confident of "โอ cells Elsevier ทา not" continue to sustain 2,009 new flu strains have the
Date 9 August 2552 Dr. honorable person the power Tanti pot joy Department of Medical Sciences. Disclosure of case reports Ramathibodi Hospital found a new virus influenza strains (H1N1) virus resist drug resistant cells ทา not โอ Elsevier. From patients in 1 of the meeting is considered a disease that resist drug in Thailand. And a signal to be more careful about the use of antiviral drugs. That is based on academics predicted that resist drug when the disease found in one country. Have the opportunity to see other countries in similar time. Because of contact by people traveling coherent All but disappeared, and no serious symptoms of patients as normal. This indicates that the volume of blood found in the body to resist drug fractional While most viruses are also sensitive to the drug is used to make drugs โอ cells ทา Elsevier has not worked.
Department of Medical Sciences. Mr. Toepfer added. Resist drug reports from the disease found in other countries. Both patients have not been drug and patients receiving drugs to prevent Found before symptom However, no transmission to people resist drug exposure near The most likely cause is a mutation of the virus resist drug. Caused by drug use in a few symptoms. Or medication to prevent symptoms before birth. Therefore must be more careful to not use the drug in case the patient has no symptoms. And not eating for drug prevention and drug people should eat according to strict medical orders to end will have even better then. To prevent the virus multiplying and resist drug epidemic.
And Dr. Wattana Investment cradle He qualified scientists and medical surveillance for the disease that resist drug found in the past. A detection that can resist drug in patients is usually treatable. May resist drug because the body's blood volume is small. Most of the disease but also to medicine. Can not use drugs โอ Elsevier ทา cells maintain effective That resist drug test blood early. A genetic examination. By random genetic take parts of some viruses. And to see that happen. The nature of disease resist drug associate. If the service culture in a bottle and then test the experimental drug may not be found infected resist drug. Therefore believe Drug โอ cells ทา Elsevier will not be able to work. In addition, reports of Center for Disease Control (CDC) United States has monitored the influenza virus strains in a number of new 2009 USA Still not found a new virus strains to 2,009 drug bovine cells โอ Elsevier ทา not show that the new virus strains that spread around the world are currently infected cells sensitive to drug โอ not ทา Elsevier.
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
<TABLE border=0 cellSpacing=0 cellPadding=0 width="100%" bgColor=#ffffff><TBODY><TR><TD>Academics: No need to panic over resistance against Oseltamivir </TD><TD vAlign=top align=right> </TD></TR><TR><TD class=line_top_bg> </TD><TD class=line_top_bg height=300 vAlign=top><TABLE border=0 cellSpacing=0 cellPadding=10 width="100%"><TBODY><TR><TD vAlign=top><TABLE><TBODY><TR><TD vAlign=top></TD><TD> </TD><TD>BANGKOK, 9 August 2009 (NNT) ? Academics have confirmed no need to panic over the discovery of the H1N1 virus?s resistance against Oseltamivir, assuring that experts will convene to discuss laboratory information tomorrow.
Following a recent news report of H1N1 patients? resistance against Oseltamivir, virologist MD Prasert Thongcharoen, as Chairperson of the Advisory Subcommittee on Medicine and Public Health, stated that he had not received an official report on the matter yet. He expected the issue to be brought up during the meeting of experts tomorrow while urging the public not to panic over the information.
MD Prasert cited that the resistance rate of the virus against Oseltamivir in Thailand was low compared to the statistics in Japan. He added that drug resistance had been found in Hong Kong, Denmark and Canada as well. He, however, admitted that this issue must be confirmed with test results from the laboratories of Chulalongkorn and Siriraj Hospitals.
Meanwhile, an expert of the Medical Services Department, MD Tawee Chotpitayasunondh, stated that resistance against Oseltamivir was not beyond expectation, but it must be considered by the number of cases. He insisted that there was no need to panic, and the treatment policy would remain the same. </TD></TR></TBODY></TABLE><TABLE style="FONT-SIZE: 10pt" border=0 cellSpacing=0 cellPadding=0 bgColor=#ffffff><TBODY><TR><TD vAlign=top width="1%" align=left>
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News ID: 255208090040
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Reporter : Santibhap Ussavasodhi
News Date : 09 August 2009
</TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE>Leave a comment:
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
BANGKOK, 9 August 2009 (NNT) ? The Ministry of Public Health has warned patients to take all 10 Oseltamivir pills for 5 consecutive days as prescribed by physicians in order to prevent drug resistance and further spread of the H1N1 virus.
Upon the report of resistance against Oseltamivir detected at Ramathibodi Hospital, Public Health Ministry Spokesperson MD Suphan Srithamma admitted its high possibility, adding that the drug being used on a large number of patients could also lead to a higher chance of resistance.
The spokesperson assured that the ministry had been very cautious in its drug prescription, elaborating that Oseltamivir was only given to patients with severe symptoms. He said the medication was most effective within 48 to 72 hours after the first indication of flu symptoms.
MD Suphan added that all people worldwide had an equal opportunity to be infected with the H1N1 flu as the majority still had no immunity against the virus. He also estimated that at present there were about 300,000 to 500,000 people in Thailand with sufficient immunity against the infection.
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Re: H1N1 STRAIN RESISTANT TO ANTIVIRALS (Thailand)
In your referenced llnk, they reported that out of 358 positives tests, there was one co-infection.Originally posted by ironorehopper View Post
If that same ratio held in Thailand, there could have been 22 co-infections.
(using 8000 positive H1N1 tests)
.Leave a comment:
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