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Date: 1 Oct 2009
Source: Taiwan Epidemiology Bulletin, Taiwan Centers for Disease Control [edited] <http:"" main_e="" news_list.aspx?id="2344">

Early release: the first 100 hospitalized severe complicated influenza cases caused by 2009 pandemic influenza A (H1N1) in Taiwan 2009/09/25

To understand the features of the severe complicated influenza patients caused by 2009 pandemic influenza A (H1N1), we retrospectively reviewed the medical records of the 1st 100 laboratory-confirmed cases (by date of onset), analyzed all clinical variables and described their clinical and epidemiologic characteristics.

The cases had onset dates from [2 Jul 2009 to 29 Aug 2009]; half of them were adults and the other half were children.

The median age was 16.5 years.

38 had preexisting medical conditions; 6 of the 50 adults were morbidly obese; 8 of the 50 children were obese, and 2 women were pregnant.

The most common initial presentations were fever (99 per cent) and cough (93 per cent).

89 patients had viral pneumonia; 23 were complicated with respiratory failure requiring mechanical ventilation, and 9 were treated with concomitant support by extra-corporeal membrane oxygenation.

By [18 Sep 2009], 82 patients recovered and were discharged from the hospitals; 9 were still hospitalized, and the remaining 9 patients (including 2 obese patients and one pregnant woman) died.

The median time between onset of symptoms and 1st doctor visit was one day, and the median hospital stay for those who had been discharged was 6 days.

The average duration from onset of symptoms to the date of rapid testing, admission, or prescription of oseltamivir for patients with onset after [15 Aug 2009] was shorter than those with onset before [15 Aug 2009].

In conclusion, most of the severe complicated influenza patients caused by 2009 pandemic influenza A (H1N1) were children and young to middle-aged adults; overweight and pregnancy posed higher risk to these patients.

The preventive and control measures conducted by the public health sector have effectively accelerated diagnosis and treatment.

However, quality of medical care remains to be improved to further reduce the number of severe complicated influenza cases and mortality.

Centers for Disease Control, Department of Health, Executive Yuan, Taiwan, R.O.C.
Copyright: All rights reserved.
2007 No. 6, Linshen South Road, Taipei, Taiwan 10050, R.O.C. Communicable Disease Reporting and Consultation Hotline: 1922

[The full article is presently only available in Chinese and can be found at <http:"" upload="" doc="" 23452_25-10-%e7%b6%b2%e8%b7%af%e9%a0%90%e5%a0%b1-%e4%b8%ad.pdf="">LINK. An English translation of the full article should be available by about 25 Oct 2009.]
communicated by:
Angela Song-En Huang, MD MPH Field Epidemiology Training Program Taiwan Centers for Disease Control <>
Jen-Hsiang Chuang, MD MS PhD Epidemic Intelligence Center Taiwan Centers for Disease Control
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