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Flu viruses resistant to new drug Xofluza uncovered in Japan

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  • Flu viruses resistant to new drug Xofluza uncovered in Japan

    Source: https://www.japantimes.co.jp/news/20.../#.XE05VvxrwQk

    Flu viruses resistant to new drug Xofluza uncovered in Japan
    Jan 27, 2019
    JIJI

    Mutated influenza viruses resistant to baloxavir marboxil, a new flu drug sold as Xofluza, were detected in patients last month, the National Institute of Infectious Diseases has said.

    This was the first confirmation of such a virus by a national research institute after the drug was put into practical use in last March, the health ministry said.

    According to the NIID, Xofluza-resistant viruses were found in two of four primary school students in Yokohama in generic screenings in December conducted after they developed flu symptoms earlier the same month.

    The mutated viruses were 76 to 120 times more resistant to the new anti-flu drug, developed by Shionogi & Co., than unmutated ones detected in the other two children.

    In clinical trials of baloxavir marboxil, resistant viruses were detected in 23.4 percent of participating patients younger than 12 years old.

    The NIID said that it will continue to keep an eye on mutated flu viruses and provide related information swiftly...
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