Check out the FAQ,Terms of Service & Disclaimers by clicking the
link. Please register
to be able to post. By viewing this site you are agreeing to our Terms of Service and Acknowledge our Disclaimers.
FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster.
The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website.
By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.
We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.
Announcement
Collapse
No announcement yet.
Japan Reports Tamiflu-Resistant H1N1 Influenza Case
The WHO says the first H1N1 infection found to be resistant to the antiviral drug Tamiflu has occurred but is an isolated case and at present has no implications for public health.
months.http://www.news-medical.net/news/200...swine-flu.aspx
H1N1 in Japan didn't get the WHO memo (and clearly doesn't read press releases).
Oseltamivir in Osaka Press Release (Products: Tamiflu) for the avian flu virus was detected indicating the mutant gene from Osaka ○ resistance, indicating that the H275Y Tamiflu-resistant isolates with a mutated avian flu virus genes were reported on the Summary, as attached, to provide information.
○ The virus, now, WHO, National Institute of Infectious Diseases in collaboration center, is scheduled to be implemented and drug susceptibility testing.
○ In Japan, about 500 nationwide surveillance by the virus are carried out in cooperation with the medical institution where the future for the new influenza virus, and not knowing what is expected from the drug-resistant gene mutation .
○ In addition, the May 15 analysis has been similar for patients who develop the virus strain, indicating the mutant gene was confirmed Tamiflu resistant.
○ その後、ご家族を含めた周囲への感染拡大は認められていない。
○ then spread to the surrounding, including the Family is not approved.
○ neuraminidase was carried out by the Osaka Prefectural Institute of Public Health (NA) part of the gene (250bp) and the analysis of mutations in the gene (point
mutation)を生じたものであり、季節性インフルエンザ(A/H1N1;
mutation) which arises, seasonal influenza (A/H1N1;
ソ連型) との交雑により生じたものではないとのこと。
Soviet-type) which is caused by hybridization of the year.
○ 6 Monday 30 of the European Center for Disease Control (ECDC) said, in Denmark, as the avian flu patients contact the rich history of travel abroad, who had prophylactic administration of Tamiflu, the drug administration 5 The tests for flu-like symptoms after day, is found to be infected with avian flu.
その後、薬剤耐性の状況を確認したところ、タミフル耐性の遺伝子変異が認められたとされている 。
Then I check the status of drug-resistant, and has been recognized that drug-resistant mutation.
○ For this case, ECDC will never be shown to isolate the virus-resistant gene mutations full TAMI patients are given Tamiflu, a phenomenon that is observed in the seasonal flu, Tamiflu will be resistant For influenza virus, has not been confirmed to be infected by the surrounding public health risk and are not considered.
May 18, the prophylactic administration of Tamiflu (10 days) had, out May 24 from a fever, and on May 28 after contact with fever consultation centers, day 29, was diagnosed with avian flu on Sunday .
I checked with the Osaka Public Health Institute in samples from patients, the June 18 show a resistance to Tamiflu H275Y mutant gene was confirmed.
なお、家族を含めた周囲への感染拡大は認められていない。
The infection spread to the surrounding, including the family is not approved.
また、5月15日に発症した患者のウイルス株についても検査したが、こちらは変異が見つからな かった。
The May 15 was also tested in patients who develop the virus strain, the mutation is not found.
大阪府立公衆衛生研究所の解析によると、今回の遺伝子変異は、当該遺伝子に突然変異(poin t mutation)を生じたものであり、季節性インフルエンザ(A/H1N1、ソ連型) との交雑により生じたものではないとしている。
According to the analysis of the Osaka Prefectural Institute of Public Health, the mutated gene, the gene mutation (point mutation) which arises, seasonal influenza (A/H1N1, type the Soviet Union) due to hybridization with It is not.
今後、国立感染症研究所において薬剤感受性試験等が実施される予定。
Do you plan to implement and drug susceptibility testing in the National Institute of Infectious Diseases.
Overseas, European Center for Disease Control (ECDC) on June 30, in Denmark, and its recognition of genetically mutated avian flu virus resistant to Tamiflu.
患者は、海外渡航歴のある新型インフルエンザ患者の濃厚接触者で、タミフルの予防投与を受けて いた。
Patients are concentrated in the contacts of patients with a history of avian flu overseas travel, had a preventive dose of Tamiflu.
TOKYO, July 3 (Xinhua) -- Japanese has detected the first genetic mutation of the new H1N1 strain of influenza A that develops resistance to the anti-flu drug Tamiflu, the health ministry said late Thursday.
The Tamiflu-resistant virus was detected in a woman in her 40s infected with the new influenza in Osaka Prefecture, it said.
The ministry added she is already recovering after being administered Relenza, another anti-flu drug.
The female patient had been administered Tamiflu since May 18 as a preventive measure after she was found to have had close contact with another confirmed infected patient the previous day. She was confirmed infected with A/H1N1 influenza on May 28. An analysis of a virus taken from her detected the genetic mutation that does not respond to Tamiflu on June 18. The first case of HINI that showed resistance to Tamiflu was reported in Denmark at the end of last month.
Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case
Clarification and additional information
AFP?s report (or Kyodo news agency?s original report) is wrong in saying that the patient was given Tamiflu since first being diagnosed with A(H1N1).
Based on the media and the official account of the case from the Ministry of Health, the patient (a female in her 40s) was given the drug on May 18 as precautionary administration (one capsule per day for 10 days) to prevent infection from a confirmed patient with whom she had had close contact. So, she was not diagnosed with novel influenza at the time she was given Tamiflu. (She should be at least rapid-tested and the result was certainly negative. It is not stated if her specimen was taken and sent for PCR test then but probably not.)
While she took the drug regularly since then, she had a mild fever from May 24, consulted a fever consultation center on May 28 and was diagnosed with novel flu on May 29. Then she was given Relenza and recovered by the end of the month.
Somebody suspected Tamiflu-resistance from the fact that she contracted novel influenza despite of the precautionary Tamiflu and her specimen was sent for further investigation including gene sequence analysis in which the Tamiflu-resistant virus was found on June 18.
On the other hand, a specimen taken from the original patient with whom she had close contact and by whom she was probably infected with novel flu was also sent for further analysis (probably after the discovery of the Tamiflu-resistant virus) but no mutation was found from the original patient?s virus.
+++++++++++++++++++++++++++++++++++++++++
Osaka prefecture apologized for not disclosing the discovery for two weeks. The prefecture explained it was conducting further investigation to confirm Tamiflu-resistance before a public announcement.
The Ministry of health was informed of the discovery of Tamiflu-resistance on July 1 by Osaka prefecture and advised the prefecture to publicize it immediately.
Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case
> Osaka prefecture apologized for not disclosing the discovery
> for two weeks. The prefecture explained it was conducting
> further investigation to confirm Tamiflu-resistance before
> a public announcement.
what's the advantage of doing "further investigation" before
public announcement ?
They are afraid that others might do the same investigation
and come up with a result before they do ?
Scientific competition ?
We must change the system, so this delaying strategy
becomes less desirable.
> Osaka prefecture apologized for not disclosing the discovery
> for two weeks. The prefecture explained it was conducting
> further investigation to confirm Tamiflu-resistance before
> a public announcement.
what's the advantage of doing "further investigation" before
public announcement ?
They are afraid that others might do the same investigation
and come up with a result before they do ?
Scientific competition ?
We must change the system, so this delaying strategy
becomes less desirable.
> Osaka prefecture apologized for not disclosing the discovery
> for two weeks. The prefecture explained it was conducting
> further investigation to confirm Tamiflu-resistance before
> a public announcement.
what's the advantage of doing "further investigation" before
public announcement ?
They are afraid that others might do the same investigation
and come up with a result before they do ?
Scientific competition ?
We must change the system, so this delaying strategy
becomes less desirable.
The Japanese are a very precise, responsible and conservative people.
A two week delay to confirm the original findings by repeating the sequencing probably more than once and obtaining a consensus among their leading flu scientists is entirely appropriate IMO.
In fact, it appears to me that they reported this finding much sooner than did the Danish authorities. For this they deserve our applause not criticism.
Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case
#21: to prevent infection from a confirmed patient with whom she had had close contact. So, she was not diagnosed with novel influenza at the time she was given Tamiflu. (She should be at least rapid-tested and the result was certainly negative. It is not stated if her specimen was taken and sent for PCR test then but probably not.)
... Somebody suspected Tamiflu-resistance from the fact that she contracted novel influenza despite of the precautionary Tamiflu and her specimen was sent for further investigation including gene sequence analysis in which the Tamiflu-resistant virus was found"
Apart the wide sample checkings, now, after few resistance cases confirmed, we can probably assume that there are worldwide many more such situations, but are not detected, because probably there weren't conducted further checkings by the above cited sequencing.
So, as an alternate option, it will be probably good that Roche/... now change the guideliness for Tamiflu prevention somministration to the same dosage as for treatment purposes, so maybe the wide resistance appearance could be slowed until vaccines appears.
If the patients on Tamiflu profilactic dose could take 1 pil a day even if maybe without the illness, they could probably take it twice a day (treatment dose) without more health repercusions.
Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case
Yes Tropical, I agree, there are probably many more cockroaches out there. We have them confirmed now in Denmark, Japan, Washington State, USA, and Hong Kong. Three contenients in three days. I think that qualifies as widespread in anyone's book.
We can argue if the 274 came about in people treated with tamiflu or whether they contracted it with the 274 polymorphism already present meaning the novel strain with this change was fit.
IMO, while we can spend our time debating these points the fact that so many examples of the novel strain have been detected with tamiflu resistance suggests to me that if it is not fit now with this change it is only a matter of time before it will be.
My read? Tamiflu is toast by the fall. We better use our tamiflu now or lose it. The US send 450,000 courses to the southern American hemisphere yesterday. Why not send a whole lot more and soon before it becomes worthless.
Comment