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Japan Reports Tamiflu-Resistant H1N1 Influenza Case

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  • #16
    Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

    Originally posted by niman View Post
    Concern over case of drug resistant swine flu

    2. July 2009 19:30

    The WHO says the first H1N1 infection found to be resistant to the antiviral drug Tamiflu has occurred but is an isolated case and at present has no implications for public health.
    months.http://www.news-medical.net/news/200...swine-flu.aspx
    H1N1 in Japan didn't get the WHO memo (and clearly doesn't read press releases).

    Comment


    • #17
      Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

      The translation at this site indicates the resistance was H274Y (aka H275Y) and was detected in a patient receiving prophylatic Tamiflu in May

      サイト説明って結構こっぱずかしいものですね〜とっ、とりあえず          日常がメインです^^そして、日常をゆる〜〜く、そして、まったりとご紹介いたします!! 面白いサイトや気になる話題もコメント欄で随時募集します。 皆さんのご来店(

      Comment


      • #18
        Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

        Originally posted by niman View Post
        The tarnsaltion at this site indicates the resistance was H274Y (aka H275Y) and was detected in a patient receiving prophylatic Tamiflu in May

        http://translate.google.com/translat...%26tbs%3Dqdr:d


        報道関係者 各位大阪府におけるオセルタミビル(商品名:タミフル)耐性を示す遺伝子変異が検出された新型インフルエン ザウイルスについて○ 大阪府から、タミフル耐性を示すH275Y の遺伝子変異を持つ新型インフルエンザウイルスが分離されたとの報告がありましたので、その概要について、 別紙のとおり、情報提供します。
        Oseltamivir in Osaka Press Release (Products: Tamiflu) for the avian flu virus was detected indicating the mutant gene from Osaka ○ resistance, indicating that the H275Y Tamiflu-resistant isolates with a mutated avian flu virus genes were reported on the Summary, as attached, to provide information.
        ○ このウイルスについては、今後、WHO 協力センターである国立感染症研究所において、薬剤感受性試験等が実施される予定です。
        ○ The virus, now, WHO, National Institute of Infectious Diseases in collaboration center, is scheduled to be implemented and drug susceptibility testing.
        ○ 我が国においては、全国で約500 箇所の医療機関の協力を得て実施しているウイルスサーベイランス等により、今後、新型インフルエンザウイル スについて、遺伝子変異による薬剤耐性がみられていないか把握することとしています。
        In Japan, about 500 nationwide surveillance by the virus are carried out in cooperation with the medical institution where the future for the new influenza virus, and not knowing what is expected from the drug-resistant gene mutation .
        ○ なお、タミフルに対する耐性を持つ遺伝子変異は、ウイルスの重篤度(病原性)には直接影響を及ぼすものでは ないとされています。
        ○ In addition, gene mutations that are resistant to Tamiflu, the severity of the virus (pathogenic) is a direct influence is not.

        大阪府におけるオセルタミビル(商品名:タミフル)耐性を示す遺伝子変異が検出された新型インフルエンザウ イルスの概要1.
        Oseltamivir in Osaka (product name: Tamiflu) Description of a new flu virus was detected in a mutant gene be resistant.
        患者の概要○ 大阪府に在住の患者から、タミフル耐性を示す遺伝子変異を持つ新型インフルエンザウイルスを検 出。
        ○ Description of patients from patients living in Osaka, with the avian flu virus resistant to Tamiflu indicates the gene mutation.
        ○ この方は、5月15日に発症し、5月17日に新型インフルエンザの患者であることが確定した患者の濃厚接触 者。
        If this is to begin on May 15, May 17, concentrated contacts of patients confirmed that the avian flu patients.
        ○ 5月18日からタミフルの予防投与(10日間)が行われていたところ、
        ○ 5 prophylactic administration of the drug from the Monday 18 days (10 days) were made,
        5月24日から微熱があり、5月28日発熱相談センターに連絡し、5月29日に新型インフルエ ンザと診断。
        May 24 with a fever on May 28 to contact the Counseling Center, fever, and on May 29 in the diagnosis of avian flu.
        5月29日から5日間ザナミビル(商品名:リレンザ)により治療を受け、回復。
        Sunday May 29 from 5-day Zanamivir (Product name: Relenza) treated by recovery.
        ○ 患者から採取された検体について、大阪府立公衆衛生研究所において、
        The samples were collected from patients in the Osaka Prefectural Institute of Public Health,
        ウイルスを分離・培養した後、遺伝子配列を確認したところ、6月18日、
        After separation of the virus culture, the gene sequence was confirmed, June 18,
        タミフル耐性を示すH275Y の遺伝子変異が確認された。
        Be resistant to Tamiflu H275Y mutant gene was confirmed.
        ○ なお、5月15日に発症した患者のウイルス株についても同様の分析が行われているが、タミフル耐性を示す遺 伝子変異は確認されなかった。
        ○ In addition, the May 15 analysis has been similar for patients who develop the virus strain, indicating the mutant gene was confirmed Tamiflu resistant.
        ○ その後、ご家族を含めた周囲への感染拡大は認められていない。
        ○ then spread to the surrounding, including the Family is not approved.
        ○ 大阪府立公衆衛生研究所によって実施されたノイラミニダーゼ(NA)遺伝子の一部(250bp)の解析によ ると、当該遺伝子に突然変異(point
        ○ neuraminidase was carried out by the Osaka Prefectural Institute of Public Health (NA) part of the gene (250bp) and the analysis of mutations in the gene (point
        mutation)を生じたものであり、季節性インフルエンザ(A/H1N1;
        mutation) which arises, seasonal influenza (A/H1N1;
        ソ連型) との交雑により生じたものではないとのこと。
        Soviet-type) which is caused by hybridization of the year.

        ○ 6月30日の欧州疾病管理センター(ECDC)の発表によると、デンマークにおいて、海外渡航歴のある新型 インフルエンザ患者の濃厚接触者として、タミフルの予防投与を受けていた方が、タミフル投与後5日目にイン フルエンザ様症状が出たため検査を行い、新型インフルエンザに感染したことが判明。
        ○ 6 Monday 30 of the European Center for Disease Control (ECDC) said, in Denmark, as the avian flu patients contact the rich history of travel abroad, who had prophylactic administration of Tamiflu, the drug administration 5 The tests for flu-like symptoms after day, is found to be infected with avian flu.
        その後、薬剤耐性の状況を確認したところ、タミフル耐性の遺伝子変異が認められたとされている 。
        Then I check the status of drug-resistant, and has been recognized that drug-resistant mutation.
        ○ 本事例について、ECDC は、タミフルが投与されている患者からタミフル耐性の遺伝子変異を示すウイルスが分離されることは、季節性 インフルエンザにおいても観察されている現象であり、今回のタミフル耐性を示すインフルエンザウイルスにつ いて、周囲の者への感染が確認されていないことから、公衆衛生上の危険はないものと考えられると評価してい る。
        ○ For this case, ECDC will never be shown to isolate the virus-resistant gene mutations full TAMI patients are given Tamiflu, a phenomenon that is observed in the seasonal flu, Tamiflu will be resistant For influenza virus, has not been confirmed to be infected by the surrounding public health risk and are not considered.
        ※ なお、ECDC の同報告書では、日本において、タミフルによる治療を受けている季節性インフルエンザに感染した子供を調べ たところ、その16
        ※ In addition, ECDC's report, in Japan, found that children infected with seasonal flu are being treated by a full TAMI, the 16
        パーセントからタミフル耐性を示すウイルスが分離されたが、その感染性は低いものであったという研究結果が 紹介されている
        The virus was separated from the TAMI shows the percent of full immunity, the infection is introduced, studies that were low.

        Comment


        • #19
          Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

          Ministry of Health on July 2, showing in Osaka H275Y Tamiflu resistance has been separated with a mutated avian flu virus genes.
          タミフル耐性の遺伝子変異はデンマークで報告されているが、国内では初となる。
          Tamiflu-resistant gene mutations have been reported in Denmark, is the first in the country.

          発表によると、患者は、5月15日に発症し、5月17日に新型インフルエンザに感染していることが確定した 患者の濃厚接触者だった。
          According to the patients, 15 developed symptoms on May Day, May 17 was concentrated contacts of patients confirmed to have infected with avian flu.
          5月18日からタミフルの予防投与(10日間)を受けていたが、5月24日から微熱が出、5月28日に発熱 相談センターに連絡後、翌29日に新型インフルエンザと診断された。
          May 18, the prophylactic administration of Tamiflu (10 days) had, out May 24 from a fever, and on May 28 after contact with fever consultation centers, day 29, was diagnosed with avian flu on Sunday .
          同日から、リレンザによる治療を受け回復したという。
          On the same day, told the treatment Relenza.

          この患者から採取された検体を大阪府公衆衛生研究所で検査したところ、6月18日にタミフル耐性を示すH2 75Yの遺伝子変異が確認された。
          I checked with the Osaka Public Health Institute in samples from patients, the June 18 show a resistance to Tamiflu H275Y mutant gene was confirmed.
          なお、家族を含めた周囲への感染拡大は認められていない。
          The infection spread to the surrounding, including the family is not approved.
          また、5月15日に発症した患者のウイルス株についても検査したが、こちらは変異が見つからな かった。
          The May 15 was also tested in patients who develop the virus strain, the mutation is not found.

          大阪府立公衆衛生研究所の解析によると、今回の遺伝子変異は、当該遺伝子に突然変異(poin t mutation)を生じたものであり、季節性インフルエンザ(A/H1N1、ソ連型) との交雑により生じたものではないとしている。
          According to the analysis of the Osaka Prefectural Institute of Public Health, the mutated gene, the gene mutation (point mutation) which arises, seasonal influenza (A/H1N1, type the Soviet Union) due to hybridization with It is not.

          今後、国立感染症研究所において薬剤感受性試験等が実施される予定。
          Do you plan to implement and drug susceptibility testing in the National Institute of Infectious Diseases.
          なお、厚労省は「タミフル耐性を示す遺伝子変異は、ウイルスの重篤度(病原性)には直接影響を及ぼすもので はないとされる」との見解を示している。
          The ministry is "drug-resistant gene mutations indicate the severity of the virus (pathogenic) is a direct influence is not," said that.

          海外では、欧州疾病管理センター(ECDC)が6月30日、デンマークで、新型インフルエンザウイルスにタ ミフル耐性の遺伝子変異が認められたと発表した。
          Overseas, European Center for Disease Control (ECDC) on June 30, in Denmark, and its recognition of genetically mutated avian flu virus resistant to Tamiflu.
          患者は、海外渡航歴のある新型インフルエンザ患者の濃厚接触者で、タミフルの予防投与を受けて いた。
          Patients are concentrated in the contacts of patients with a history of avian flu overseas travel, had a preventive dose of Tamiflu.
          タミフル投与後5日目にインフルエンザ様症状が出たため検査を行ったところ、新型インフルエンザに感染した ことが分かった。
          5 after administration of drug testing is done for the flu-like symptoms after day, it was found infected with avian flu.
          その後、薬剤耐性の状況を確認したところ、耐性の遺伝子変異が検出されたという。
          Then I check the status of drug resistance, gene mutation was found resistant.
          こちらのケースでも、周囲への感染が確認されていないことから、公衆衛生上の危険はないものと考えられてい る。
          In this case, it is not around to confirm the infection, public health risk is not considered.

          ■ oseltamivir in the office of the Ministry of Labor released Osaka thickness (Products: Tamiflu) for the avian flu virus was detected indicating the resistant gene mutation

          Comment


          • #20
            Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

            <TABLE class=lan18 border=0 cellSpacing=0 cellPadding=0 width="97%" align=center><TBODY><TR><TD class=hei22 height=25 vAlign=bottom>Japan reports first case of Tamiflu-resistant H1N1 flu
            </TD></TR><TR><TD bgColor=#ffffff height=4></TD></TR></TBODY></TABLE><TABLE border=0 cellSpacing=0 cellPadding=0 width="50%" align=center><TBODY><TR><TD height=8></TD></TR></TBODY></TABLE><TABLE border=0 cellSpacing=0 cellPadding=0 width="97%" align=center><TBODY><TR><TD width="48%">www.chinaview.cn 2009-07-03 09:10:07</TD><TD class=hui12 width="26%" align=middle> </TD><TD class=hui12 width="12%" align=middle> Print</TD></TR></TBODY></TABLE><TABLE border=0 cellSpacing=0 cellPadding=0 width="80%"><TBODY><TR><TD height=20></TD></TR></TBODY></TABLE><TABLE class=lt14 border=0 cellSpacing=0 cellPadding=0 width="97%" align=center><TBODY><TR><TD class=lt14>


            TOKYO, July 3 (Xinhua) -- Japanese has detected the first genetic mutation of the new H1N1 strain of influenza A that develops resistance to the anti-flu drug Tamiflu, the health ministry said late Thursday.

            The Tamiflu-resistant virus was detected in a woman in her 40s infected with the new influenza in Osaka Prefecture, it said.
            The ministry added she is already recovering after being administered Relenza, another anti-flu drug.
            The female patient had been administered Tamiflu since May 18 as a preventive measure after she was found to have had close contact with another confirmed infected patient the previous day. She was confirmed infected with A/H1N1 influenza on May 28. An analysis of a virus taken from her detected the genetic mutation that does not respond to Tamiflu on June 18. The first case of HINI that showed resistance to Tamiflu was reported in Denmark at the end of last month.



            </TD></TR></TBODY></TABLE>

            Comment


            • #21
              Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

              Clarification and additional information

              AFP?s report (or Kyodo news agency?s original report) is wrong in saying that the patient was given Tamiflu since first being diagnosed with A(H1N1).

              Based on the media and the official account of the case from the Ministry of Health, the patient (a female in her 40s) was given the drug on May 18 as precautionary administration (one capsule per day for 10 days) to prevent infection from a confirmed patient with whom she had had close contact. So, she was not diagnosed with novel influenza at the time she was given Tamiflu. (She should be at least rapid-tested and the result was certainly negative. It is not stated if her specimen was taken and sent for PCR test then but probably not.)

              While she took the drug regularly since then, she had a mild fever from May 24, consulted a fever consultation center on May 28 and was diagnosed with novel flu on May 29. Then she was given Relenza and recovered by the end of the month.

              Somebody suspected Tamiflu-resistance from the fact that she contracted novel influenza despite of the precautionary Tamiflu and her specimen was sent for further investigation including gene sequence analysis in which the Tamiflu-resistant virus was found on June 18.

              On the other hand, a specimen taken from the original patient with whom she had close contact and by whom she was probably infected with novel flu was also sent for further analysis (probably after the discovery of the Tamiflu-resistant virus) but no mutation was found from the original patient?s virus.

              +++++++++++++++++++++++++++++++++++++++++

              Osaka prefecture apologized for not disclosing the discovery for two weeks. The prefecture explained it was conducting further investigation to confirm Tamiflu-resistance before a public announcement.
              The Ministry of health was informed of the discovery of Tamiflu-resistance on July 1 by Osaka prefecture and advised the prefecture to publicize it immediately.

              __________________________
              SN1987A

              Comment


              • #22
                Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

                Another cockroach.

                Not a surprise.

                GW
                The Doctor

                Comment


                • #23
                  Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

                  > Osaka prefecture apologized for not disclosing the discovery
                  > for two weeks. The prefecture explained it was conducting
                  > further investigation to confirm Tamiflu-resistance before
                  > a public announcement.

                  what's the advantage of doing "further investigation" before
                  public announcement ?
                  They are afraid that others might do the same investigation
                  and come up with a result before they do ?
                  Scientific competition ?

                  We must change the system, so this delaying strategy
                  becomes less desirable.
                  I'm interested in expert panflu damage estimates
                  my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

                  Comment


                  • #24
                    Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

                    Originally posted by gsgs View Post
                    > Osaka prefecture apologized for not disclosing the discovery
                    > for two weeks. The prefecture explained it was conducting
                    > further investigation to confirm Tamiflu-resistance before
                    > a public announcement.

                    what's the advantage of doing "further investigation" before
                    public announcement ?
                    They are afraid that others might do the same investigation
                    and come up with a result before they do ?
                    Scientific competition ?

                    We must change the system, so this delaying strategy
                    becomes less desirable.
                    The delay was for accuracy.

                    Comment


                    • #25
                      Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

                      Originally posted by gsgs View Post
                      > Osaka prefecture apologized for not disclosing the discovery
                      > for two weeks. The prefecture explained it was conducting
                      > further investigation to confirm Tamiflu-resistance before
                      > a public announcement.

                      what's the advantage of doing "further investigation" before
                      public announcement ?
                      They are afraid that others might do the same investigation
                      and come up with a result before they do ?
                      Scientific competition ?

                      We must change the system, so this delaying strategy
                      becomes less desirable.
                      The Japanese are a very precise, responsible and conservative people.

                      A two week delay to confirm the original findings by repeating the sequencing probably more than once and obtaining a consensus among their leading flu scientists is entirely appropriate IMO.

                      In fact, it appears to me that they reported this finding much sooner than did the Danish authorities. For this they deserve our applause not criticism.

                      GW
                      The Doctor

                      Comment


                      • #26
                        Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

                        preliminary data needn't be so accurate.
                        Mark it as "draft" or such.

                        This is like reporting about a war only after it's over.
                        For accuracy.
                        I'm interested in expert panflu damage estimates
                        my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

                        Comment


                        • #27
                          Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

                          #21: to prevent infection from a confirmed patient with whom she had had close contact. So, she was not diagnosed with novel influenza at the time she was given Tamiflu. (She should be at least rapid-tested and the result was certainly negative. It is not stated if her specimen was taken and sent for PCR test then but probably not.)
                          ...
                          Somebody suspected Tamiflu-resistance from the fact that she contracted novel influenza despite of the precautionary Tamiflu and her specimen was sent for further investigation including gene sequence analysis in which the Tamiflu-resistant virus was found"



                          Apart the wide sample checkings, now, after few resistance cases confirmed, we can probably assume that there are worldwide many more such situations, but are not detected, because probably there weren't conducted further checkings by the above cited sequencing.

                          So, as an alternate option, it will be probably good that Roche/... now change the guideliness for Tamiflu prevention somministration to the same dosage as for treatment purposes, so maybe the wide resistance appearance could be slowed until vaccines appears.

                          If the patients on Tamiflu profilactic dose could take 1 pil a day even if maybe without the illness, they could probably take it twice a day (treatment dose) without more health repercusions.

                          Comment


                          • #28
                            Re: Hong Kong: Detection of human swine influenza virus resistant to Tamiflu (7/3/09)

                            More cockroaches. They seem to be pretty widespread now or at least they are being reported now.

                            GW
                            The Doctor

                            Comment


                            • #29
                              Re: Japan Reports Tamiflu-Resistant H1N1 Influenza Case

                              Yes Tropical, I agree, there are probably many more cockroaches out there. We have them confirmed now in Denmark, Japan, Washington State, USA, and Hong Kong. Three contenients in three days. I think that qualifies as widespread in anyone's book.

                              We can argue if the 274 came about in people treated with tamiflu or whether they contracted it with the 274 polymorphism already present meaning the novel strain with this change was fit.

                              IMO, while we can spend our time debating these points the fact that so many examples of the novel strain have been detected with tamiflu resistance suggests to me that if it is not fit now with this change it is only a matter of time before it will be.

                              My read? Tamiflu is toast by the fall. We better use our tamiflu now or lose it. The US send 450,000 courses to the southern American hemisphere yesterday. Why not send a whole lot more and soon before it becomes worthless.

                              GW
                              The Doctor

                              Comment


                              • #30
                                Re: Hong Kong: Detection of human swine influenza virus resistant to Tamiflu (7/3/09)

                                cockroaches ?

                                HSI, another name. One name for each country/researcher.

                                2 weeks
                                I'm interested in expert panflu damage estimates
                                my current links: http://bit.ly/hFI7H ILI-charts: http://bit.ly/CcRgT

                                Comment

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