Japan - 2 new outbreaks of highly pathogenic influenza H5N6 in crows in Itami city, Hyogo (OIE, April 27, 2018)

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Highly pathogenic influenza A viruses (infection with) (non-poultry including wild birds), Japan

Information received on 27/04/2018 from Dr Kazuo Ito, Director, International Animal Health Affairs Office, Animal Health Division, Food Safety and Consumer Affairs Bureau, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan

Summary Report type Follow-up report No. 6 Date of start of the event 05/11/2017 Date of confirmation of the event 09/11/2017 Report date 27/04/2018 Date submitted to OIE 27/04/2018 Reason for notification Recurrence of a listed disease Date of previous occurrence 08/03/2017 Manifestation of disease Clinical disease Causal agent Highly pathogenic influenza A virus Serotype H5N6 Nature of diagnosis Laboratory (basic), Laboratory (advanced) This event pertains to a defined zone within the country Related reports Immediate notification (10/11/2017) Follow-up report No. 1 (13/11/2017) Follow-up report No. 2 (24/11/2017) Follow-up report No. 3 (22/01/2018) Follow-up report No. 4 (09/03/2018) Follow-up report No. 5 (23/03/2018) Follow-up report No. 6 (27/04/2018)

New outbreaks (2)

Outbreak 1 Itami city, Hyogo Date of start of the outbreak 18/03/2018 Outbreak status Resolved (18/03/2018) Epidemiological unit Not applicable Affected animals Species Susceptible Cases Deaths Killed and disposed of Slaughtered Large-billed Crow:Corvus macrorhynchos(Corvidae) 1 1 0 0

Outbreak 2 Itami city, Hyogo Date of start of the outbreak 25/03/2018 Outbreak status Resolved (25/03/2018) Epidemiological unit Not applicable Affected animals Species Susceptible Cases Deaths Killed and disposed of Slaughtered Large-billed Crow:Corvus macrorhynchos(Corvidae) 1 1 0 0

Summary of outbreaks Total outbreaks: 2 Total animals affected Species Susceptible Cases Deaths Killed and disposed of Slaughtered Large-billed Crow:Corvus macrorhynchos(Corvidae) 2 2 0 0 Outbreak statistics Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost* Large-billed Crow:Corvus macrorhynchos(Corvidae) ** ** 100.00% ** *Removed from the susceptible population through death, destruction and/or slaughter **Not calculated because of missing information

Epidemiology Source of the outbreak(s) or origin of infection Unknown or inconclusive Epidemiological comments Large-billed crows (Corvus macrorhynchos) were found dead in Itami city and tested positive for influenza A virus with rapid tests. Then confirmatory tests were carried out in Tottori University and H5N6 highly pathogenic avian influenza virus was detected in 2 samples.

Control measures Measures applied Screening Disinfection Vaccination prohibited No treatment of affected animals Measures to be applied No other measures

Diagnostic test results Laboratory name and type Species Test Test date Result Tottori University (Private Laboratory) Large-billed Crow gene sequencing 30/03/2018 Positive Tottori University (Private Laboratory) Large-billed Crow gene sequencing 04/04/2018 Positive Tottori University (Private Laboratory) Large-billed Crow haemagglutination (HA) test 30/03/2018 Positive Tottori University (Private Laboratory) Large-billed Crow haemagglutination (HA) test 04/04/2018 Positive Tottori University (Private Laboratory) Large-billed Crow haemagglutination inhibition test (HIT) 30/03/2018 Positive Tottori University (Private Laboratory) Large-billed Crow haemagglutination inhibition test (HIT) 04/04/2018 Positive Tottori University (Private Laboratory) Large-billed Crow reverse transcription - polymerase chain reaction (RT-PCR) 30/03/2018 Positive Tottori University (Private Laboratory) Large-billed Crow reverse transcription - polymerase chain reaction (RT-PCR) 04/04/2018 Positive Tottori University (Private Laboratory) Large-billed Crow virus isolation 30/03/2018 Positive Tottori University (Private Laboratory) Large-billed Crow virus isolation 04/04/2018 Positive

Future Reporting The event is continuing. Weekly follow-up reports will be submitted.

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