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Bangladesh - Kamalapur, Dhaka, female, 16 months, H5N1 positive (second human case in Bangladesh)

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  • Bangladesh - Kamalapur, Dhaka, female, 16 months, H5N1 positive (second human case in Bangladesh)

    First human bird flu case detected this year


    Mon, Mar 14th, 2011 6:27 pm BdST



    Dhaka, Mar 14 (bdnews24.com) — The first case of human infection of avian influenza or bird flu this year has been detected, confirms the Institute of Epidemiology, Disease Control and Research (IEDCR).


    IEDCR director Mahmudur Rahman told bdnews24.com that the human infection was confirmed on Monday after testing the samples of saliva and nasal discharge of a 13-month-old girl running temperature, who visited an influenza surveillance centre recently.

    The surveillance centre is run jointly by the IEDCR and International Centre for Diarrhoeal Diseases and Research, Bangladesh (ICDDR,B), according to him.


    Proper treatment of the patient had already been ensured, the IEDCR director said.

    http://www.bdnews24.com/details.php?id=189801&cid=2

  • #2
    Re: Bangladesh - Female, 13 months, H5N1 positive

    This is actually the 2nd confirmed case in Bangladesh. Please see:

    Bangladesh: first human case of H5N1 bird flu 2008


    WHO chart:

    http://www.who.int/csr/disease/avian.../en/index.html

    Comment


    • #3
      Re: Bangladesh - Female, 13 months, H5N1 positive

      Since the presence of avian influenza virus A(H5N1) in Bangladesh is widespread due to recurrence of poultry epizootics - with hundreds of thousands chickens deaths for the infection or destruction - further human cases are anticipated.

      Comment


      • #4
        Re: Bangladesh - Female, 13 months, H5N1 positive

        A mild infection points to human adaption of this H5N1 virus strain ?


        Tuesday, March 15, 2011

        Girl detected with bird flu virus

        Staff Correspondent

        A 13-month-old girl was detected with bird flu virus in the capital yesterday.

        The minor girl of the city's Kamalapur area was taken to the Institute of Epidemiology, Disease Control and Research (IEDCR) with fever where doctors found “mild symptoms” of the virus in her body, said IEDCR Director Mahmudur Rahman.

        This is the second case of human infection of bird flu, also known as avian influenza (H5N1), in the country.

        The girl, however, is not having any serious breathing problem, which is normally the case.

        The symptom is so mild that it has been detected because of the extensive surveillance, Mahmudur said, adding that proper treatment of the girl has been ensured.

        "She is fine now and will recover soon."

        The first human infection was detected on May 22, 2008. Also in the capital, it was a 15-month-old boy who fully recovered after treatment at the IEDCR.

        The IEDCR director advised to take precautionary measures including properly washing hands and avoiding infected chickens, as the virus affected the poultry firms in the country in the last several months.

        thedailystar
        “Addressing chronic disease is an issue of human rights – that must be our call to arms"
        Richard Horton, Editor-in-Chief The Lancet

        ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

        Comment


        • #5
          Re: Bangladesh - Female, 13 months, H5N1 positive

          Oropharyngeal swab specimens and lower respiratory tract specimens (e.g., bronchoalveolar lavage or tracheal aspirates) are preferred because they appear to have the highest quantity of virus for H5N1 detection and Nasal or nasopharyngeal swab specimens contain less virus and therefore not be optimal for virus detection.

          (...)
          This is one of the things we need to track for major changes in H5N1 epidemiology. Up to date most bird flu infections are negative in rapid test and then confirmed by lower respiratory tract specimens in laboratory, this is mainly due to a better adaptation to 2-3 sialylated glycans in bird flu strains, including H5N1 currently in circulation.

          But, now in the last months we're seeing more cases confirmed by upper respiratory tract specimens in endemic regions. What we don't know if this is due to new protocols for testing or a change in the virus that allows it to bind to 2-6 sialylated glycans better. Sequences from latest cases would be very useful.

          A mild course of infection with H5N1 is nothing new, but in fact it's estimated that if H5N1 sparks the new pandemic will be far less severe than the current case fatality rate known, it will be at 5% to 10% (this is a worst case scenario). Of course influenza is unpredictable and a severer or milder pandemic might emerge. It's well known that many bird flu cases go underreported, not only because governments failing at providing a better infrastructure or not sharing publicly this information, but also because of mild infection like in Bangladesh or some others in Egypt.

          Right now, Indonesia is something to keep an eye as some patients have tested positive for influenza by rapid test and they had a mild infection where sick and dead poultry is being reported daily.Indonesia don't like to report these cases , so we won't know the results unless an epidemic begins in the area and maybe it also will take some time.

          Comment


          • #6
            Re: Bangladesh - Female, 13 months, H5N1 positive (second human case in Bangladesh)

            Source: http://www.bdnews24.com/details.php?id=189940&cid=2

            Efforts on to nip bird flu in the bud


            Wed, Mar 16th, 2011 12:48 am BdST

            Dial 2000 from your GP mobile for latest news
            Dhaka, Mar 16 (bdnews24.com) – The Institute of Epidemiology Disease Control and Research (IEDCR) has started mopping up the area where the country's second avian influenza human case has been detected.

            A 13-month girl in the capital's crowded Kamlapur area was the first case this year and latest human case since March 2007 when the virus first hit the poultry.

            Director Prof Mahmudur Rahman told bdnews24.com that they had launched extensive search operation, as there might be more unreported cases in the community.

            He said they were working on ascertaining the source of infection of the baby.

            "Those coming in close contact with the baby even five days prior to her showing the symptoms on March 9 will also be followed up," he said, adding that the girl showed up mild symptoms, but strong surveillance made it possible to detect the virus quickly.

            He, however, urged the people not to panic, rather be aware of the virus.

            "Maintaining bio-security in poultry farms and personal hygiene can keep the virus away," he said, adding that the virus had the potential to cause severe illness in humans with a high fatality rate.

            "The strain (clade 2.2) of H5N1, which circulates in Bangladesh, is less virulent, so it causes less infection to humans," he said, adding it could change into another class (2.1), which was highly infectious to human.

            The first case in May 2008, a 15-month-old boy...

            Comment


            • #7
              Re: Bangladesh - Female, 13 months, H5N1 positive (second human case in Bangladesh)

              The World Health Organization received notification of the confirmed H5N1 Bangladeshi human case.

              See at http://www.who.int/csr/disease/avian.../en/index.html

              Comment


              • #8
                Re: Bangladesh - Female, 13 months, H5N1 positive (second human case in Bangladesh)

                WHO announcement on this case.

                Avian influenza - situation in Bangladesh

                16 March 2011 - The Ministry of Health and Family Welfare, Government of the People's Republic of Bangladesh has confirmed a case of human infection with avian influenza A (H5N1) virus. The case was detected through the influenza sentinel surveillance centre run by the Institute of Epidemiology Disease Control and Research (IEDCR) and the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B).

                The case is a 16 month old female from Kamalapur, Dhaka. She presented at a influenza sentinel surveillance on 8 March with a history of cough and fever and subsequently recovered.

                A detailed epidemiological investigation and contact follow up is being conducted by a team of epidemiologists from IEDCR, ICDDRB and WHO Bangladesh.

                The case was confirmed as being infected with A(H5N1) by the Institute of Epidemiology Disease Control and Research (IEDCR).

                http://www.who.int/csr/don/2011_03_16/en/index.html
                http://novel-infectious-diseases.blogspot.com/

                Comment


                • #9
                  Re: Bangladesh - Kamalapur, Dhaka, female, 16 months, H5N1 positive (second human case in Bangladesh)

                  <TABLE border=0 cellSpacing=2 cellPadding=2 width="100%"><TBODY><TR><TD vAlign=top colSpan=2><TABLE border=0 cellSpacing=2 cellPadding=2 width="100%"><TBODY><TR><TD vAlign=top width="100%" colSpan=2>2011-03-17 03:51:38 - Epidemic Hazard - Bangladesh



                  </TD></TR><TR><TD width="100%" colSpan=2></TD></TR><TR><TD vAlign=top><TABLE class=ecxdata border=0 cellSpacing=1 cellPadding=1 width="100%" align=left><TBODY><TR><TD width="25%">EDIS Code:</TD><TD>EH-20110317-29969-BGD</TD></TR><TR><TD>Date&Time:</TD><TD>2011-03-17 03:51:38 [UTC]</TD></TR><TR><TD>Continent:</TD><TD>Asia</TD></TR><TR><TD>Country:</TD><TD>Bangladesh</TD></TR><TR><TD>State/Prov.:</TD><TD>Capital City, </TD></TR><TR><TD>Location:</TD><TD>, </TD></TR><TR><TD>City:</TD><TD>Dhaka</TD></TR><TR><TD colSpan=2>Number of infected people: 2

                  Not confirmed information!

                  </TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE>


                  Health officials in Bangladesh have confirmed another H5N1 avian influenza infection, the second one in a week, reported today. The new case is in a 2-year-old boy who appeared at a surveillance site in Kamalapur with mild symptoms that included a fever and cough. Tests on the boy's respiratory and serum samples were conducted by the country's Institute of Epidemiology Disease Control and Research (IEDCR). Dr Mahmudur Rahman, director of the IEDCR, told bdnews24 that the strain (clade 2.2) of the H5N1 virus that circulates in Bangladesh is less virulent than other strains. The boy's illness was detected during surveillance related to the investigation of another recently reported case, in a 13-month-old girl whose infection was confirmed today by the World Health Organization (WHO). However, Rahman said the boy is not related to the girl. The WHO said in its statement today that Bangladesh's health ministry has confirmed a 16-month-old girl's infection with the H5N1 influenza. Her illness was reported by the media on Mar 14. In its statement, the WHO said the girl's infection was detected at an IEDCR surveillance center in Kamalapur in Dhaka state. She was brought to the center on Mar 8 with cough and fever and has since recovered. An investigation into the source of her illness is being conducted by Bangladeshi and WHO officials. Her illness, plus the boy's infection, raise Bangladesh's H5N1 case total to 3, none of which have been fatal. The other infection occurred in 2008, in a 16-month-old boy. If the WHO confirms today's reported case, the global H5N1 case count would rise to 535, including 316 deaths.

                  </TD></TR><TR><TD vAlign=top colSpan=2>The name of Hazard: A/H5N1
                  Species: Human
                  Status: Confirmed

                  </TD></TR><TR><TD align=right>Posted:2011-03-17 03:51:38 [UTC]


                  </TD></TR></TBODY></TABLE>

                  Comment


                  • #10
                    Re: Bangladesh - Kamalapur, Dhaka, female, 16 months, H5N1 positive (second human case in Bangladesh)

                    Another human case of bird flu surfaces

                    <!-- Breaking News and Subtitle part by Hasan --><!-- Breaking News part Ends--><!-- Rating part starts--><FORM method=post action=http://theindependentbd.com/national/39359-another-human-case-of-bird-flu-surfaces.html>http://theindependentbd.com/national...-surfaces.html</FORM>

                    Wednesday, 16 March 2011 <!--edited by HASAN-->
                    Author / Source : independent online/bdnews24.com


                    Dhaka: Another human case of avian influenza has been detected in the Kamalapur area of the capital, two days after a 13-month-old girl was found carrying the H5N1 virus in the same locality.

                    The Institute of Epidemiology Disease Control and Research (IEDCR) discovered the fresh case while mopping up the area on Wednesday. It launched a drive in the locality following the detection of first case of the year in the area on Sunday.

                    IEDCR director Prof Mahmudur Rahman told bdnews24.com that a 31-month-old boy had been detected carrying the virus in their lab.

                    They tested nasal as well as throat swab and blood to confirm the case. The boy showed up with mild symptoms including fever and cough at the IEDCR and ICDDR,B joint surveillance site at Kamalapur, the director said.

                    Prof Rahman, however, said that the boy was not related to the earlier case.

                    So far, three people have been detected infected with the bird flu virus since its first outbreak in March 2007 in poultry.

                    IEDCR urged people not to panic, rather be aware of the disease.

                    Comment


                    • #11
                      Re: Bangladesh - Kamalapur, Dhaka, female, 16 months, H5N1 positive (second human case in Bangladesh)

                      Information about the new human case noted in post # 10 by solitaire can be found in this thread: http://www.flutrackers.com/forum/sho...d.php?t=164386
                      http://novel-infectious-diseases.blogspot.com/

                      Comment


                      • #12
                        Re: Bangladesh - Kamalapur, Dhaka, female, 16 months, H5N1 positive (second human case in Bangladesh)

                        Comment from ProMED moderator:

                        The 2 human cases of avian influenza A/H5N1 virus infection
                        identified recently in the Kamalapur area of Dhaka (only the 2nd and
                        3rd cases ever recorded in Bangladesh) are unusually in that both are
                        young children with mild symptoms of respiratory infection. Exposure
                        to infected poultry is a common feature, but otherwise the cases are
                        unrelated. It seems likely that their detection has been the result of
                        a particularly comprehensive and sensitive surveillance system, and
                        possibly the prevalence in Bangladesh of a strain of virus with
                        reduced virulence for humans
                        .


                        ProMED
                        “Addressing chronic disease is an issue of human rights – that must be our call to arms"
                        Richard Horton, Editor-in-Chief The Lancet

                        ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~

                        Comment


                        • #13
                          Re: Bangladesh - Kamalapur, Dhaka, female, 16 months, H5N1 positive (second human case in Bangladesh)

                          Source: World Health Organization, Weekly Epidemiological Record, full PDF document: http://www.who.int/wer/2011/wer8611.pdf

                          Table 1 Worldwide influenza A(H5N1) activity, 27 September 2010 to 15 February 2011

                          [Country, area or territory – Host – Genetic clade ]
                          • Bangladesh - Poultry – Unknown
                          • Cambodia – Poultry – 1
                            • Human (1)a – 1
                          • China, Hong Kong SAR – Wild birds – 2.3.2
                            • Human (1) – 2.3.2
                            • Poultry (chicken carcass) – 2.3.4
                          • Egypt – Poultry – 2.2.1
                            • Humans (10) – 2.2.1
                          • Indonesia – Poultry – 2.1.3
                            • Humans (2) – 2.1.2
                          • Japan – Wild birds – 2.3.2
                            • Poultry – 2.3.2
                          • Myanmar - Poultry – 2.3.4
                          • Nepal – Poultry – 2.3.2
                          • Republic of Korea – Wild birds – 2.3.2
                            • Poultry – 2.3.2
                          • Viet Nam - Poultry – 2.3.2, 2.3.4

                          (a) Numbers in parentheses denote the number of confirmed cases occurring during this period.

                          (...)
                          -
                          ------

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