Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus
+ Author Affiliations
Abstract
We investigated the evolution and epidemiology of a novel livestock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes and infects urban-dwelling Danes even without a Danish animal reservoir. Genetic evidence suggests both poultry and human adaptation, with poultry meat implicated as a probable source.
- Jesper Larsen1,
- Marc Stegger1,5,
- Paal S. Andersen1,2,
- Andreas Petersen1,
- Anders R. Larsen1,
- Henrik Westh2,3,
- Yvonne Agers?4,
- Alexandra Fetsch7,
- Britta Kraushaar7,
- Annemarie K?sbohrer7,
- Andrea T. Feβler8,
- Stefan Schwarz8,
- Christiane Cuny9,
- Wolfgang Witte9,
- Patrick Butaye10,12,
- Olivier Denis11,
- Marisa Haenni13,
- Jean-Yves Madec13,
- Eric Jouy16,
- Frederic Laurent14,15,
- Antonio Battisti17,
- Alessia Franco17,
- Patricia Alba17,
- Caterina Mammina19,
- Annalisa Pantosti18,
- Monica Monaco18,
- Jaap A. Wagenaar20,22,
- Enne de Boer21,
- Engeline van Duijkeren23,
- Max Heck23,
- Lucas Dom?nguez24,
- Carmen Torres25,
- Myriam Zarazaga25,
- Lance B. Price5,6,a, and
- Robert L. Skov1,a
+ Author Affiliations
- 1Statens Serum Institut, Copenhagen
- 2University of Copenhagen, Frederiksberg
- 3Hvidovre Hospital
- 4Technical University of Denmark, Lyngby
- 5Translational Genomics Research Institute, Flagstaff, Arizona
- 6George Washington University, Washington D.C.
- 7Federal Institute for Risk Assessment, Berlin
- 8Friedrich-Loeffler-Institut, Neustadt-Mariensee
- 9Robert Koch Institut, Wernigerode, Germany
- 10Ghent University
- 11Universit? Libre de Bruxelles, Brussels, Belgium
- 12Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis
- 13French Agency for Food, Environmental and Occupational Health and Safety, Lyon
- 14Universit? Claude Bernard Lyon 1
- 15Hospices Civils de Lyon
- 16French Agency for Food, Environmental and Occupational Health and Safety, Ploufragan, France
- 17Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana
- 18Istituto Superiore di Sanit?, Rome
- 19University of Palermo, Italy
- 20Utrecht University
- 21Netherlands Food and Consumer Product Safety Authority, Utrecht
- 22Central Veterinary Institute, Lelystad
- 23National Institute for Public Health and the Environment, Bilthoven, The Netherlands
- 24Complutense University of Madrid
- 25University of La Rioja, Logro?o, Spain
- Correspondence: J. Larsen, Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark (jrl@ssi.dk).
- ↵a L. B. P. and R. L. S. are joint senior authors.
Abstract
We investigated the evolution and epidemiology of a novel livestock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes and infects urban-dwelling Danes even without a Danish animal reservoir. Genetic evidence suggests both poultry and human adaptation, with poultry meat implicated as a probable source.