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Belgium - Another Colistin Resistant Gene Detected: MCR-2

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  • Belgium - Another Colistin Resistant Gene Detected: MCR-2

    Eurosurveillance, Volume 21, Issue 27, 07 July 2016
    Rapid communication

    IDENTIFICATION OF A NOVEL PLASMID-MEDIATED COLISTIN-RESISTANCE GENE, MCR-2, INESCHERICHIA COLI, BELGIUM, JUNE 2016






    We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistantEscherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.





    Following the report of of mcr-1 detection in China in November 2015 [1], we screened 105 colistin-resistantEscherichia coli (colistin minimum inhibitory concentration (MIC) 4?8 mg/L [2]) isolated during 2011?12 from passive surveillance of diarrhoea in 52 calves and 53 piglets in Belgium [3]. mcr-1 was detected in 12.4% (n = 13) of the E. coliisolates, of which six and seven were from calves and piglets, respectively [3,4]. In the present study, we analysed porcine and bovine colistin-resistant Escherichia coli isolates that did not show presence of mcr-1 and identified a novel plasmid-mediated colistin resistance-conferring gene, mcr-2.

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    ?Addressing chronic disease is an issue of human rights ? that must be our call to arms"
    Richard Horton, Editor-in-Chief The Lancet

    ~~~~ Twitter:@GertvanderHoek ~~~ GertvanderHoek@gmail.com ~~~
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