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Euro Surveill. Carbapenemase-producing Klebsiella pneumoniae in the Czech Republic in 2011

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  • Euro Surveill. Carbapenemase-producing Klebsiella pneumoniae in the Czech Republic in 2011

    [Source: Eurosurveillance, full page: (LINK). Abstract, edited.]


    Eurosurveillance, Volume 18, Issue 45, 07 November 2013

    Surveillance and outbreak reports

    Carbapenemase-producing Klebsiella pneumoniae in the Czech Republic in 2011

    J Hrabák <SUP>1</SUP>, C C Papagiannitsis<SUP>1</SUP>, V Študentová<SUP>1</SUP>, V Jakubu<SUP>2</SUP>, M Fridrichová<SUP>2</SUP>, H Zemlickova<SUP>2</SUP>, Czech Participants of European Antimicrobial Resistance Surveillance Network<SUP>3</SUP>
    <SUP></SUP>
    <SUP>1</SUP>Department of Microbiology, Faculty of Medicine and University Hospital in Plzeň, Charles University in Prague, Plzeň, Czech Republic; 2 National Reference Laboratory for Antibiotics, National Institute for Health, Prague, Czech Republic; 3 The members of the network are listed at the end of the article
    ________

    Citation style for this article: Hrabák J, Papagiannitsis CC, Študentová V, Jakubu V, Fridrichová M, Zemlickova H, Czech Participants of European Antimicrobial Resistance Surveillance Network. Carbapenemase-producing Klebsiella pneumoniae in the Czech Republic in 2011. Euro Surveill. 2013;18(45):pii=20626. Available online: http://www.eurosurveillance.org/View...rticleId=20626
    Date of submission: 30 January 2013

    _________

    Carbapenemase-producing Enterobacteriaceae and Pseudomonas spp. are increasingly reported in many countries all over the world. Due to the resistance of those bacteria to almost all antibiotics (e.g. beta-lactams, aminoglycosides, fluoroquinolones), treatment options are seriously limited. In the Czech Republic, the incidence of carbapenemase-producing Enterobacteriaceae seems to be low, restricted to only three cases detected between 2009 and 2010. Here, we describe molecular typing of 15 carbapenemase-producing Klebsiella pneumoniae isolates identified in the Czech Republic during 2011. Five VIM-1-producing isolates belonging to sequence type (ST) 11 and one VIM-4-producing isolate of ST1029 have been detected. bla<SUB>VIM-1</SUB> and bla<SUB>VIM-4</SUB> as a part of class 1 integrons were chromosomally located or carried by a plasmid belonging to A/C replicon type (bla<SUB>VIM-4</SUB>). KPC-3-producing isolates of ST512, recovered from six patients, caused an outbreak. Three more isolates producing KPC-2 enzyme belonged to ST258. Both bla<SUB>KPC</SUB> genes were part of the Tn4401a transposon carried on plasmids of the pKpQIL type. The isolates were resistant to all antibiotics tested except colistin and/or gentamicin. Four of these 15 strains were recovered from patients repatriated to the Czech Republic from Greece and Italy. This is the first report of outbreaks caused by carbapenemase-producing Enterobacteriaceae in the Czech Republic.


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