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Antimicrob Agents Chemother. Effectiveness of disinfectants used in hemodialysis against both Candida orthopsilosis and C. parapsilosis sensu stricto biofilms.
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Effectiveness of disinfectants used in hemodialysis against both Candida orthopsilosis and C. parapsilosis sensu stricto biofilms.
Regina Helena Pires a, Julhiany de F?tima da Silva a, Carlos Henrique Gomes Martins b, Ana Marisa Fusco Almeida a, Christiane Pienna Soares a and Maria Jos? Soares Mendes-Giannini a,*
Author Affiliations: <SUP>a</SUP>Departamento de An?lises Cl?nicas, Faculdade de Ci?ncias Farmac?uticas, Univ Estadual Paulista ? UNESP, Araraquara, SP, Brazil <SUP>b</SUP>Laborat?rio de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Franca, SP, Brazil.
ABSTRACT
Biofilms have been observed in the fluid pathways of hemodialysis machines. The impacts of four biocides used for the disinfection of hemodialysis systems were tested against Candida parapsilosis sensu stricto and C. orthopsilosis biofilms generated by isolates obtained from a hydraulic circuit, which were collected in a hemodialysis unit. Acetic acid was shown to be the most effective agent against Candida biofilms. Strategies for effective disinfection procedures used for hemodialysis systems should also seek to kill and inhibit biofilms.
FOOTNOTES
* Corresponding author: E-mail: giannini@fcfar.unesp.br, Departamento de An?lises Cl?nicas, Faculdade de Ci?ncias Farmac?uticas, UNESP ? Univ Estadual Paulista. Araraquara, SP, Brasil. Rua Expedicion?rios do Brasil, 1621. Araraquara ? SP ? 14801-902 ? Brazil. Phone: +55 (16) 33015716, Fax: +55 (16) 33015714.
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
-Regina Helena Pires a, Julhiany de F?tima da Silva a, Carlos Henrique Gomes Martins b, Ana Marisa Fusco Almeida a, Christiane Pienna Soares a and Maria Jos? Soares Mendes-Giannini a,*
Author Affiliations: <SUP>a</SUP>Departamento de An?lises Cl?nicas, Faculdade de Ci?ncias Farmac?uticas, Univ Estadual Paulista ? UNESP, Araraquara, SP, Brazil <SUP>b</SUP>Laborat?rio de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Franca, SP, Brazil.
ABSTRACT
Biofilms have been observed in the fluid pathways of hemodialysis machines. The impacts of four biocides used for the disinfection of hemodialysis systems were tested against Candida parapsilosis sensu stricto and C. orthopsilosis biofilms generated by isolates obtained from a hydraulic circuit, which were collected in a hemodialysis unit. Acetic acid was shown to be the most effective agent against Candida biofilms. Strategies for effective disinfection procedures used for hemodialysis systems should also seek to kill and inhibit biofilms.
FOOTNOTES
* Corresponding author: E-mail: giannini@fcfar.unesp.br, Departamento de An?lises Cl?nicas, Faculdade de Ci?ncias Farmac?uticas, UNESP ? Univ Estadual Paulista. Araraquara, SP, Brasil. Rua Expedicion?rios do Brasil, 1621. Araraquara ? SP ? 14801-902 ? Brazil. Phone: +55 (16) 33015716, Fax: +55 (16) 33015714.
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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