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Antimicrob Agents Chemother. Novel 16S Ribosomal RNA Methyltransferase RmtH Produced by Klebsiella pneumoniae Associated with War-Related Trauma
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Novel 16S Ribosomal RNA Methyltransferase RmtH Produced by Klebsiella pneumoniae Associated with War-Related Trauma
Jessica A. O'Hara 1, Patrick McGann 2, Erik C. Snesrud 2, Robert J. Clifford 2, Paige E. Waterman 2, Emil P. Lesho 2 and Yohei Doi 1
Author Affiliations: <SUP>1</SUP>Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania <SUP>2</SUP>Multidrug-resistant organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland
ABSTRACT
Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high minimum inhibitory concentrations of all aminoglycosides including arbekacin. A gene encoding a novel 16S ribosomal RNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
-Jessica A. O'Hara 1, Patrick McGann 2, Erik C. Snesrud 2, Robert J. Clifford 2, Paige E. Waterman 2, Emil P. Lesho 2 and Yohei Doi 1
Author Affiliations: <SUP>1</SUP>Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania <SUP>2</SUP>Multidrug-resistant organism Repository and Surveillance Network (MRSN), Walter Reed Army Institute of Research, Silver Spring, Maryland
ABSTRACT
Klebsiella pneumoniae strain MRSN2404 was isolated from the chronic wound of a soldier who had been wounded in Iraq in 2006. The strain displayed very high minimum inhibitory concentrations of all aminoglycosides including arbekacin. A gene encoding a novel 16S ribosomal RNA methyltransferase, now designated RmtH, was identified. RmtH had 64% identity with RmtB1 and RmtB2. rmtH was bracketed by two copies of ISCR2, which may have played a role in its mobilization.
Copyright ? 2013, American Society for Microbiology. All Rights Reserved.
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