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Antimicrob Agents Chemother. Changing Epidemiology of Extended-Spectrum β-Lactamases in Argentina: Emergence of CTX-M-15
[Source: Antimicrobial Agents and Chemotherapy, full text: (LINK). Abstract, edited.]
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Changing Epidemiology of Extended-Spectrum β-Lactamases in Argentina: Emergence of CTX-M-15
S. Sennati<SUP>a</SUP>, G. Santella<SUP>b</SUP>, J. Di Conza<SUP>b</SUP>, L. Pallecchi<SUP>a</SUP>, M. Pino<SUP>b</SUP>, B. Ghiglione<SUP>b</SUP>, G. M. Rossolini<SUP>a</SUP>,<SUP>c</SUP>, M. Radice<SUP>b</SUP> and G. Gutkind<SUP>b</SUP>
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Author Affiliations: <SUP>a</SUP>Dipartimento di Biotecnologie, Sezione di Microbiologia, Universit? di Siena, Siena, Italy <SUP>b</SUP>Facultad de Farmacia y Bioqu?mica, Universidad de Buenos Aires, Buenos Aires, Argentina <SUP>c</SUP>Dipartimento di Emergenza, Urgenza e dei Servizi Diagnostici, U. O. Microbiologia e Virologia, Azienda Ospedaliera-Universitaria Senese, Siena, Italy
ABSTRACT
A multicenter survey, carried out in 2010 in Argentina, showed an increased prevalence of extended-spectrum β-lactamase (ESBL)-producing enterobacteria, with some changes in the molecular epidemiology of circulating ESBLs. While enzymes of the CTX-M-2 group remain endemic, the emergence of CTX-M-15 and of enzymes of the CTX-M-8 and CTX-M-9 groups was observed. The CTX-M-15-positive isolates represented 40% of CTX-M producers and included representatives of Escherichia coli ST131 and Klebsiella pneumoniae ST11.
<SUP></SUP>
Author Affiliations: <SUP>a</SUP>Dipartimento di Biotecnologie, Sezione di Microbiologia, Universit? di Siena, Siena, Italy <SUP>b</SUP>Facultad de Farmacia y Bioqu?mica, Universidad de Buenos Aires, Buenos Aires, Argentina <SUP>c</SUP>Dipartimento di Emergenza, Urgenza e dei Servizi Diagnostici, U. O. Microbiologia e Virologia, Azienda Ospedaliera-Universitaria Senese, Siena, Italy
ABSTRACT
A multicenter survey, carried out in 2010 in Argentina, showed an increased prevalence of extended-spectrum β-lactamase (ESBL)-producing enterobacteria, with some changes in the molecular epidemiology of circulating ESBLs. While enzymes of the CTX-M-2 group remain endemic, the emergence of CTX-M-15 and of enzymes of the CTX-M-8 and CTX-M-9 groups was observed. The CTX-M-15-positive isolates represented 40% of CTX-M producers and included representatives of Escherichia coli ST131 and Klebsiella pneumoniae ST11.
FOOTNOTES
Received 17 April 2012. Returned for modification 24 June 2012. Accepted 12 August 2012.
Address correspondence to G. Gutkind, ggutkind@ffyb.uba.ar.
Published ahead of print 20 August 2012
Copyright ? 2012, American Society for Microbiology. All Rights Reserved.
-Received 17 April 2012. Returned for modification 24 June 2012. Accepted 12 August 2012.
Address correspondence to G. Gutkind, ggutkind@ffyb.uba.ar.
Published ahead of print 20 August 2012
Copyright ? 2012, American Society for Microbiology. All Rights Reserved.
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