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Hong Kong, CHP detects case of metallo-beta-lactamase 2009 Carbapenemase-producing Enterobacteriaceae (September 25 2012): 14th case

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  • Hong Kong, CHP detects case of metallo-beta-lactamase 2009 Carbapenemase-producing Enterobacteriaceae (September 25 2012): 14th case

    [Source: Centre for Health Protection, Hong Kong PRC SAR, full page: (LINK).]
    CHP detects case of NDM Carbapenemase-producing Enterobacteriaceae


    The Public Health Laboratory Services Branch (PHLSB) of the Centre for Health Protection (CHP) of the Department of Health has identified a case of New Delhi metallo-β-lactamase (NDM) Carbapenemase-producing Enterobacteriaceae in a 57-year-old man.

    The patient, with underlying illness, travelled to Guangzhou for an operation between the end of August and September 12.

    He was admitted to Queen Mary Hospital on September 13 for persistent wound pain and other symptoms of facial flushing, malaise and shortness of breath.

    His condition improved and he was later discharged from hospital on September 21.

    His rectal swab collected on September 13 tested positive for NDM Carbapenemase-producing Enterobacteriaceae.

    His home contact had no symptoms of infection.

    Investigation by the CHP is continuing.

    This is the 14th detected case of NDM Carbapenemase-producing Enterobacteriaceae in Hong Kong.

    The spokesman explained that NDM is an enzyme which can inactivate carbapenems and other beta-lactams such as penicillins. Bacteria harbouring this NDM gene are commonly resistant to multiple antimicrobials, limiting therapeutic options and rendering severe clinical infections difficult to treat. Most bacteria with the NDM enzyme remain susceptible to two types of antibiotics, colistin and tigecycline.

    Infections have varied from being asymptomatic to potentially life-threatening or fatal. The level of risk depends on which part of the body is affected by the infection, and the general health of the patient.

    NDM-producing Enterobacteriaceae was first reported in a Swedish patient of Indian origin who travelled to New Delhi, India, in 2008. The first fatal case was identified in 2010 in a patient who received medical treatment in Pakistan before being repatriated to Belgium.

    NDM-producing Enterobacteriaceae has now been reported in many countries and regions including Australia, Austria, Canada, Belgium, France, Germany, Japan, the Netherlands, Norway, Oman, Sweden, Singapore, Taiwan, the UK and the US. Most patients had prior hospital contact in the Indian subcontinent.

    The spokesman said that proper use of antibiotics and personal hygiene, especially hand hygiene, are important for the prevention of emergence and cross transmission of NDM strains.


    Ends/Tuesday, September 25, 2012
    Issued at HKT 18:25
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